Leveraging sequence specificity, form programmability, and spatial addressability, DNA nanotechnology permits the nanometer-precise development of DNA nanodevices for a variety of organic functions. This minireview summarizes current progress in using self-assembled DNA nanostructures as scaffolds for creating superior nanodevices as biosensors. We spotlight notable developments in ultrasensitive detection, multiplexed sensing, and focused molecular bioimaging. These self-assembled DNA nanodevices are designed for clever sensing of assorted analytes, providing revolutionary options for biomedical diagnostics and environmental surveillance. Challenges associated to the detection precision, stability, and scalable manufacturing of those promising DNA-based biosensors are additionally mentioned.
