Covalent natural frameworks (COFs) have emerged as a flexible class of crystalline reticular supplies distinguished by their excessive floor space, everlasting porosity, and atomically exact structural tunability. Their modular synthesis allows exact management over pore dimension, geometry, and floor performance, whereas providing glorious chemical stability and intrinsic biocompatibility. These attributes make COFs uniquely suited to purposes as precision nanocarriers in focused drug supply. Latest advances exhibit that COFs can encapsulate therapeutic brokers with excessive loading effectivity and facilitate managed, stimuli-responsive launch profiles. Moreover, the incorporation of focusing on moieties by means of linker design or post-synthetic modification allows site-specific supply, minimizing off-target cytotoxicity and enhancing therapeutic efficacy-particularly in oncological contexts. This evaluation critically evaluates the present panorama of COF-based drug supply techniques, detailing structural design methods, loading and launch mechanisms, and functionalization approaches for precision focusing on. We additionally spotlight key challenges-such as scalable synthesis, pharmacokinetics, and in vivo stability-and define promising analysis instructions towards the medical translation of COF nanocarriers for customized drugs.
