Ledley FD. Pharmaceutical strategy to somatic gene remedy. Pharm Res. 1996;13:1595–614.
Li X, Hu Y, Zhang X, Shi X, Parak WJ, Pich A. Transvascular transport of nanocarriers for tumor supply. Nat Commun. 2024;15:8172.
Solar X, Setrerrahmane S, Li C, Hu J, Xu H. Nucleic acid medication: latest progress and future views. Sign Transduct Goal Ther. 2024;9:316.
Wang B, Hu S, Teng Y, Chen J, Wang H, Xu Y, Wang Okay, Xu J, Cheng Y, Gao X. Present advance of nanotechnology in prognosis and therapy for malignant tumors. Sign Transduct Goal Ther. 2024;9:200.
Karlsson J, Luly KM, Tzeng SY, Inexperienced JJ. Nanoparticle designs for supply of nucleic acid therapeutics as mind most cancers therapies. Adv Drug Deliv Rev. 2021;179:113999.
Garbayo E, El Moukhtari SH, Rodriguez-Nogales C, Agirre X, Rodriguez-Madoz JR, Rodriguez-Marquez P, Prosper F, Couvreur P, Blanco-Prieto MJ. RNA-loaded nanoparticles for the therapy of hematological cancers. Adv Drug Deliv Rev. 2024;214:115448.
Zhu D, Kim WJ, Lee H, Bao X, Kim P. Engineering CAR-T therapeutics for enhanced stable tumor concentrating on. Adv Mater. 2025;e2414882.
Park M, Lim J, Lee S, Nah Y, Kang Y, Kim WJ. Nanoparticle-Mediated explosive Anti-PD-L1 manufacturing facility inbuilt tumor for superior immunotherapy. Adv Mater. 2025;e2417735.
Skowicki M, Tarvirdipour S, Kraus M, Schoenenberger CA, Palivan CG. Nanoassemblies designed for environment friendly nuclear concentrating on. Adv Drug Deliv Rev. 2024;211:115354.
Wong KY, Nie Z, Wong MS, Wang Y, Liu J. Metallic-Drug coordination nanoparticles and hydrogels for enhanced supply. Adv Mater. 2024;36:e2404053.
Jogdeo CM, Siddhanta Okay, Das A, Ding L, Panja S, Kumari N, Oupicky D. Past lipids: exploring advances in polymeric gene supply within the lipid nanoparticles period. Adv Mater. 2024;36:e2404608.
Xu L, Shao Z, Fang X, Xin Z, Zhao S, Zhang H, Zhang Y, Zheng W, Yu X, Zhang Z, Solar L. Exploring precision remedies in immune-mediated inflammatory ailments: Harnessing the infinite potential of nucleic acid supply. Exploration. 2024.
Seaside MA, Nayanathara U, Gao Y, Zhang C, Xiong Y, Wang Y, Such GK. Polymeric nanoparticles for drug supply. Chem Rev. 2024;124:5505–616.
Zhao Z, Ukidve A, Kim J, Mitragotri S. Focusing on methods for Tissue-Particular drug supply. Cell. 2020;181:151–67.
Piotrowski-Daspit AS, Bracaglia LG, Eaton DA, Richfield O, Binns TC, Albert C, Gould J, Mortlock RD, Egan ME, Pober JS, Saltzman WM. Enhancing in vivo cell and tissue concentrating on by modulation of polymer nanoparticles and macrophage decoys. Nat Commun. 2024;15:4247.
Wang MZ, Niu J, Ma HJ, Dad HA, Shao HT, Yuan TJ, Peng LH. Transdermal SiRNA supply by pH-switchable micelles with concentrating on impact suppress pores and skin melanoma development. J Management Launch. 2020;322:95–107.
Liu S, Wen Y, Shan X, Ma X, Yang C, Cheng X, Zhao Y, Li J, Mi S, Huo H, et al. Cost-assisted stabilization of lipid nanoparticles allows inhaled mRNA supply for mucosal vaccination. Nat Commun. 2024;15:9471.
Chen Okay, Han H, Zhao S, Xu B, Yin B, Lawanprasert A, Trinidad M, Burgstone BW, Murthy N, Doudna JA. Lung and liver enhancing by lipid nanoparticle supply of a steady CRISPR-Cas9 ribonucleoprotein. Nat Biotechnol. 2024.
Chatterjee S, Kon E, Sharma P, Peer D. Endosomal escape: A bottleneck for LNP-mediated therapeutics. Proc Natl Acad Sci U S A. 2024;121:e2307800120.
Han X, Gong N, Xue L, Billingsley MM, El-Mayta R, Shepherd SJ, Alameh MG, Weissman D, Mitchell MJ. Ligand-tethered lipid nanoparticles for focused RNA supply to deal with liver fibrosis. Nat Commun. 2023;14:75.
Chen J, Hu S, Solar M, Shi J, Zhang H, Yu H, Yang Z. Latest advances and scientific translation of liposomal supply programs in most cancers remedy. Eur J Pharm Sci. 2024;193:106688.
Modell AE, Lim D, Nguyen TM, Sreekanth V, Choudhary A. CRISPR-based therapeutics: present challenges and future functions. Developments Pharmacol Sci. 2022;43:151–61.
Papke B, Van Swearingen AE, Feng AY, Azam SH, Harrison EB, Yang R, Cox AD, Der CJ, Pecot CV. Summary B32: Silencing of oncogenic KRAS by a mutant-favoring quick interfering RNA. Mol Most cancers Res. 2020;18:B32–32.
Dechbumroong P, Hu R, Keaswejjareansuk W, Namdee Okay, Liang X-J. Latest superior lipid-based nanomedicines for overcoming most cancers resistance. Most cancers Drug Resist. 2024;7:24.
Ho W, Gao M, Li F, Li Z, Zhang XQ, Xu X. Subsequent-Technology vaccines: Nanoparticle-Mediated DNA and mRNA supply. Adv Healthc Mater. 2021;10:e2001812.
Zahed Z, Hadi R, Imanzadeh G, Ahmadian Z, Shafiei S, Zadeh AZ, Karimi H, Akbarzadeh A, Abbaszadeh M, Ghadimi LS. Latest advances in fluorescence nanoparticles quantum Dots as gene supply system: A assessment. Int J Biol Macromol. 2024;254:127802.
Lee KX, Shameli Okay, Yew YP, Teow SY, Jahangirian H, Rafiee-Moghaddam R, Webster TJ. Latest developments within the facile Bio-Synthesis of gold nanoparticles (AuNPs) and their biomedical functions. Int J Nanomed. 2020;15:275–300.
Li W, Cao Z, Liu R, Liu L, Li H, Li X, Chen Y, Lu C, Liu Y. AuNPs as an essential inorganic nanoparticle utilized in drug provider programs. Artif Cells Nanomed Biotechnol. 2019;47:4222–33.
Khutale GV, Casey A. Synthesis and characterization of a multifunctional gold-doxorubicin nanoparticle system for pH triggered intracellular anticancer drug launch. Eur J Pharm Biopharm. 2017;119:372–80.
Chuang CC, Cheng CC, Chen PY, Lo C, Chen YN, Shih MH, Chang CW. Gold nanorod-encapsulated biodegradable polymeric matrix for mixed photothermal and chemo-cancer remedy. Int J Nanomed. 2019;14:181–93.
Liu L, Cai R, Wang Y, Tao G, Ai L, Wang P, Yang M, Zuo H, Zhao P, He H. Polydopamine-Assisted silver nanoparticle Self-Meeting on Sericin/Agar movie for potential wound dressing utility. Int J Mol Sci. 2018;19.
Wojnicki M, Luty-Błocho M, Kotańska M, Wytrwal M, Tokarski T, Krupa A, Kołaczkowski M, Bucki A, Kobielusz M. Novel and efficient synthesis protocol of AgNPs functionalized utilizing L-cysteine as a possible drug provider. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:123–30.
Chen ZA, Wu CH, Wu SH, Huang CY, Mou CY, Wei KC, Yen Y, Chien IT, Runa S, Chen YP, Chen P. Receptor Ligand-Free mesoporous silica nanoparticles: A streamlined technique for focused drug supply throughout the Blood-Mind barrier. ACS Nano. 2024;18:12716–36.
An M, Li M, Xi J, Liu H. Silica nanoparticle as a lymph node concentrating on platform for vaccine supply. ACS Appl Mater Interfaces. 2017;9:23466–75.
Zhou XF, Zhuang YC, Zhang MH, Sheng H, Solar QF, He L. Relativistic synthetic molecule of two coupled graphene quantum Dots at tunable distances. Nat Commun. 2024;15:8786.
Zuo H, Chen W, Cooper HM, Xu ZP. A facile method of modifying layered double hydroxide nanoparticles with concentrating on Ligand-Conjugated albumin for enhanced supply to mind tumour cells. ACS Appl Mater Interfaces. 2017;9:20444–53.
Xu ZP, Stevenson GS, Lu CQ, Lu GQ, Bartlett PF, Grey PP. Steady suspension of layered double hydroxide nanoparticles in aqueous resolution. J Am Chem Soc. 2006;128:36–7.
Xu ZP, Stevenson G, Lu CQ, Lu GQ. Dispersion and measurement management of layered double hydroxide nanoparticles in aqueous options. J Phys Chem B. 2006;110:16923–9.
Cao Z, Li B, Solar L, Li L, Xu ZP, Gu Z. 2D layered double hydroxide nanoparticles: latest progress towards preclinical/scientific nanomedicine. Small Strategies. 2020;4:1900343.
Gao C, Jiang J, Zhao J, Xu ZP, Zhang L. Engineered nano-aluminum adjuvant for most cancers immunotherapy: progress, challenges and alternatives in the direction of preclinical/scientific utility. Coord Chem Rev. 2024;519:216109.
Valadi H, Ekström Okay, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated switch of mRNAs and MicroRNAs is a novel mechanism of genetic change between cells. Nat Cell Biol. 2007;9:654–9.
Stranford DM, Simons LM, Berman KE, Cheng L, DiBiase BN, Hung ME, Lucks JB, Hultquist JF, Leonard JN. Genetically encoding a number of functionalities into extracellular vesicles for the focused supply of biologics to T cells. Nat Biomed Eng. 2024;8:397–414.
Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wooden MJ. Supply of SiRNA to the mouse mind by systemic injection of focused exosomes. Nat Biotechnol. 2011;29:341–5.
Bonsergent E, Grisard E, Buchrieser J, Schwartz O, Théry C, Lavieu G. Quantitative characterization of extracellular vesicle uptake and content material supply inside mammalian cells. Nat Commun. 2021;12:1864.
Cheng L, Hill AF. Therapeutically Harnessing extracellular vesicles. Nat Rev Drug Discov. 2022;21:379–99.
Hu Q, Li H, Wang L, Gu H, Fan C. DNA Nanotechnology-Enabled drug supply programs. Chem Rev. 2019;119:6459–506.
Li Y, Cai Z, Ma W, Bai L, Luo E, Lin Y. A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior supply of Curcumin and alleviation of diabetic osteoporosis. Bone Res. 2024;12:14.
Luo L, Li J, Zhou Y, Xiang D, Luan Y, Wang Q, Huang J, Liu J, Yang X, Wang Okay. Spatially managed DNA frameworks for delicate detection and particular isolation of tumor cells. Angew Chem Int Ed Engl. 2024;63:e202411382.
Sellner S, Kocabey S, Nekolla Okay, Krombach F, Liedl T, Rehberg M. DNA nanotubes as intracellular supply autos in vivo. Biomaterials. 2015;53:453–63.
Zhuang X, Ma X, Xue X, Jiang Q, Track L, Dai L, Zhang C, Jin S, Yang Okay, Ding B, et al. A Photosensitizer-Loaded DNA Origami nanosystem for photodynamic remedy. ACS Nano. 2016;10:3486–95.
Pan Q, Nie C, Hu Y, Yi J, Liu C, Zhang J, He M, He M, Chen T, Chu X. Aptamer-Functionalized DNA Origami for focused codelivery of antisense oligonucleotides and doxorubicin to reinforce remedy in Drug-Resistant Most cancers cells. ACS Appl Mater Interfaces. 2020;12:400–9.
Behzadi S, Serpooshan V, Tao W, Hamaly MA, Alkawareek MY, Dreaden EC, Brown D, Alkilany AM, Farokhzad OC, Mahmoudi M. Mobile uptake of nanoparticles: journey contained in the cell. Chem Soc Rev. 2017;46:4218–44.
Foroozandeh P, Aziz AA. Perception into mobile uptake and intracellular trafficking of nanoparticles. Nanoscale Res Lett. 2018;13:339.
Sohrabi Kashani A, Packirisamy M. Most cancers-Nano-Interplay: from mobile uptake to Mechanobiological responses. Int J Mol Sci. 2021;22:9587.
Abdulrahman A, Ghanem A. Latest advances in chromatographic purification of plasmid DNA for gene remedy and DNA vaccines: A assessment. Anal Chim Acta. 2018;1025:41–57.
Shigeta Okay, Kawakami S, Higuchi Y, Okuda T, Yagi H, Yamashita F, Hashida M. Novel histidine-conjugated galactosylated cationic liposomes for environment friendly hepatocyte-selective gene switch in human hepatoma HepG2 cells. J Management Launch. 2007;118:262–70.
Togashi R, Tanaka H, Nakamura S, Yokota H, Tange Okay, Nakai Y, Yoshioka H, Harashima H, Akita H. A hepatic pDNA supply system based mostly on an intracellular setting delicate vitamin E-scaffold lipid-like materials with the help of an anti-inflammatory drug. J Management Launch. 2018;279:262–70.
Sahin U, Kariko Okay, Tureci O. mRNA-based therapeutics–growing a brand new class of medicine. Nat Rev Drug Discov. 2014;13:759–80.
Miao L, Zhang Y, Huang L. mRNA vaccine for most cancers immunotherapy. Mol Most cancers. 2021;20:41.
Li Y, Ma X, Yue Y, Zhang Okay, Cheng Okay, Feng Q, Ma N, Liang J, Zhang T, Zhang L, et al. Speedy floor show of mRNA antigens by Micro organism-Derived outer membrane vesicles for a customized tumor vaccine. Adv Mater. 2022;34:e2109984.
Zhou F, Huang L, Li S, Yang W, Chen F, Cai Z, Liu X, Xu W, Lehto VP, Lächelt U, et al. From structural design to supply: mRNA therapeutics for most cancers immunotherapy. Exploration. 2024;4:20210146.
Cullis PR, Felgner PL. The 60-year evolution of lipid nanoparticles for nucleic acid supply. Nat Rev Drug Discov. 2024;23:709–22.
Mulligan MJ, Lyke KE, Kitchin N, Absalon J, Gurtman A, Lockhart S, Neuzil Okay, Raabe V, Bailey R, Swanson KA, et al. Section I/II research of COVID-19 RNA vaccine BNT162b1 in adults. Nature. 2020;586:589–93.
Jackson LA, Anderson EJ, Rouphael NG, Roberts PC, Makhene M, Coler RN, McCullough MP, Chappell JD, Denison MR, Stevens LJ, et al. An mRNA vaccine in opposition to SARS-CoV-2 – Preliminary report. N Engl J Med. 2020;383:1920–31.
Wu L, Yi W, Yao S, Xie S, Peng R, Zhang J, Tan W. mRNA-Primarily based Most cancers vaccines: developments and prospects. Nano Lett. 2024;24:12711–21.
Li Z, Zhang XQ, Ho W, Li F, Gao M, Bai X, Xu X. Enzyme-Catalyzed One-Step synthesis of ionizable cationic lipids for lipid Nanoparticle-Primarily based mRNA COVID-19 vaccines. ACS Nano. 2022;16:18936–50.
Li B, Luo X, Deng B, Wang J, McComb DW, Shi Y, Gaensler KM, Tan X, Dunn AL, Kerlin BA, Dong Y. An orthogonal array optimization of Lipid-like nanoparticles for mRNA supply in vivo. Nano Lett. 2015;15:8099–107.
Dhaliwal HK, Fan Y, Kim J, Amiji MM. Intranasal supply and transfection of mRNA therapeutics within the mind utilizing cationic liposomes. Mol Pharm. 2020;17:1996–2005.
Rizvi F, Everton E, Smith AR, Liu H, Osota E, Beattie M, Tam Y, Pardi N, Weissman D, Gouon-Evans V. Murine liver restore through transient activation of regenerative pathways in hepatocytes utilizing lipid nanoparticle-complexed nucleoside-modified mRNA. Nat Commun. 2021;12:613.
Hou X, Zaks T, Langer R, Dong Y. Lipid nanoparticles for mRNA supply. Nat Rev Mater. 2021;6:1078–94.
Philipp J, Dabkowska A, Reiser A, Frank Okay, Krzyszton R, Brummer C, Nickel B, Blanchet CE, Sudarsan A, Ibrahim M, et al. pH-dependent structural transitions in cationic ionizable lipid mesophases are crucial for lipid nanoparticle operate. Proc Natl Acad Sci U S A. 2023;120:e2310491120.
Kranz LM, Diken M, Haas H, Kreiter S, Loquai C, Reuter KC, Meng M, Fritz D, Vascotto F, Hefesha H, et al. Systemic RNA supply to dendritic cells exploits antiviral defence for most cancers immunotherapy. Nature. 2016;534:396–401.
LoPresti ST, Arral ML, Chaudhary N, Whitehead KA. The alternative of helper lipids with charged alternate options in lipid nanoparticles facilitates focused mRNA supply to the spleen and lungs. J Management Launch. 2022;345:819–31.
Sahay G, Alakhova DY, Kabanov AV. Endocytosis of nanomedicines. J Management Launch. 2010;145:182–95.
Patel S, Ashwanikumar N, Robinson E, Xia Y, Mihai C, Griffith JP third, Hou S, Esposito AA, Ketova T, Welsher Okay, et al. Naturally-occurring ldl cholesterol analogues in lipid nanoparticles induce polymorphic form and improve intracellular supply of mRNA. Nat Commun. 2020;11:983.
Radmand A, Kim H, Beyersdorf J, Dobrowolski CN, Zenhausern R, Paunovska Okay, Huayamares SG, Hua X, Han Okay, Loughrey D, et al. Cationic cholesterol-dependent LNP supply to lung stem cells, the liver, and coronary heart. Proc Natl Acad Sci U S A. 2024;121:e2307801120.
Fischer D, Li Y, Ahlemeyer B, Krieglstein J, Kissel T. In vitro cytotoxicity testing of polycations: affect of polymer construction on cell viability and hemolysis. Biomaterials. 2003;24:1121–31.
Packer M, Gyawali D, Yerabolu R, Schariter J, White P. A novel mechanism for the lack of mRNA exercise in lipid nanoparticle supply programs. Nat Commun. 2021;12:6777.
Li B, Manan RS, Liang SQ, Gordon A, Jiang A, Varley A, Gao G, Langer R, Xue W, Anderson D. Combinatorial design of nanoparticles for pulmonary mRNA supply and genome enhancing. Nat Biotechnol. 2023;41:1410–5.
Bannigan P, Aldeghi M, Bao Z, Hase F, Aspuru-Guzik A, Allen C. Machine studying directed drug formulation improvement. Adv Drug Deliv Rev. 2021;175:113806.
Wang W, Chen Okay, Jiang T, Wu Y, Wu Z, Ying H, Yu H, Lu J, Lin J, Ouyang D. Synthetic intelligence-driven rational design of ionizable lipids for mRNA supply. Nat Commun. 2024;15:10804.
Xu Y, Ma S, Cui H, Chen J, Xu S, Gong F, Golubovic A, Zhou M, Wang KC, Varley A, et al. AGILE platform: a deep studying powered strategy to speed up LNP improvement for mRNA supply. Nat Commun. 2024;15:6305.
Sanchez-Lengeling B, Aspuru-Guzik A. Inverse molecular design utilizing machine studying: generative fashions for matter engineering. Science. 2018;361:360–5.
Liu Okay, Solar X, Jia L, Ma J, Xing H, Wu J, Gao H, Solar Y, Boulnois F, Fan J. Chemi-net: a molecular graph convolutional community for correct drug property prediction. Int J Mol Sci. 2019;20:3389.
Silver D, Huang A, Maddison CJ, Guez A, Sifre L, Van Den Driessche G, Schrittwieser J, Antonoglou I, Panneershelvam V, Lanctot M. Mastering the sport of go along with deep neural networks and tree search. Nature. 2016;529:484–9.
Gu Y, Chen J, Wang Z, Liu C, Wang T, Kim CJ, Durikova H, Fernandes S, Johnson DN, De Rose R, et al. mRNA supply enabled by metal-organic nanoparticles. Nat Commun. 2024;15:9664.
Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug supply. Nat Rev Drug Discov. 2021;20:101–24.
Su Z, Boucetta H, Shao J, Huang J, Wang R, Shen A, He W, Xu ZP, Zhang L. Subsequent-generation aluminum adjuvants: Immunomodulatory layered double hydroxide NanoAlum reengineered from first-line medication. Acta Pharm Sin B. 2024;14:4665–82.
Zhang L, Bai J, Shen A, Zhao J, Su Z, Wang M, Dong M, Xu ZP. Artificially tagging tumors with nano-aluminum adjuvant-tethered antigen mRNA recruits and prompts antigen-specific cytotoxic T cells for enhanced most cancers immunotherapy. Biomaterials. 2025;317:123085.
Jain RG, Fletcher SJ, Manzie N, Robinson KE, Li P, Lu E, Brosnan CA, Xu ZP, Mitter N. Foliar utility of clay-delivered RNA interference for whitefly management. Nat Crops. 2022;8:535–48.
Yong J, Wu M, Zhang R, Bi S, Mann CWG, Mitter N, Carroll BJ, Xu ZP. Clay nanoparticles effectively ship small interfering RNA to intact plant leaf cells. Plant Physiol. 2022;190:2187–202.
Yong J, Xu W, Wu M, Zhang R, Mann CWG, Liu G, Brosnan CA, Mitter N, Carroll BJ, Xu ZP. Lysozyme-coated nanoparticles for energetic uptake and supply of artificial RNA and plasmid-encoded genes in vegetation. Nat Crops. 2025;11:131–44.
Betti F, Ladera-Carmona MJ, Weits DA, Ferri G, Iacopino S, Novi G, Svezia B, Kunkowska AB, Santaniello A, Piaggesi A, et al. Exogenous MiRNAs induce post-transcriptional gene Silencing in vegetation. Nat Crops. 2021;7:1379–88.
Yoon J, Shin M, Lee JY, Lee SN, Choi JH, Choi JW. RNA interference (RNAi)-based plasmonic nanomaterials for most cancers prognosis and remedy. J Management Launch. 2022;342:228–40.
Haussecker D, Kay MA. RNA interference. Drugging RNAi. Science. 2015;347:1069–70.
Wang Q, Tian Y, Liu L, Chen C, Zhang W, Wang L, Guo Q, Ding L, Fu H, Track H, et al. Exact concentrating on remedy of orthotopic gastric carcinoma by SiRNA and chemotherapeutic drug codelivered in pH-Delicate nano platform. Adv Healthc Mater. 2021;10:e2100966.
Tang X, Sheng Q, Xu C, Li M, Rao J, Wang X, Lengthy Y, Tao Y, He X, Zhang Z, He Q. pH/ATP cascade-responsive nano-courier with environment friendly tumor concentrating on and SiRNA unloading for photothermal-immunotherapy. Nano Right this moment. 2021;37:101083.
Xu J, Liu Y, Li Y, Wang H, Stewart S, Van der Jeught Okay, Agarwal P, Zhang Y, Liu S, Zhao G, et al. Exact concentrating on of POLR2A as a therapeutic technique for human triple damaging breast most cancers. Nat Nanotechnol. 2019;14:388–97.
Chen Y, Huang Y, Li Q, Luo Z, Zhang Z, Huang H, Solar J, Zhang L, Solar R, Bain DJ, et al. Focusing on Xkr8 through nanoparticle-mediated in situ co-delivery of SiRNA and chemotherapy medication for most cancers immunochemotherapy. Nat Nanotechnol. 2023;18:193–204.
Li M, Solar J, Zhang W, Zhao Y, Zhang S, Zhang S. Drug supply programs based mostly on CD44-targeted glycosaminoglycans for most cancers remedy. Carbohydr Polym. 2021;251:117103.
Mi Y, Mu C, Wolfram J, Deng Z, Hu TY, Liu X, Blanco E, Shen H, Ferrari M. A micro/nano composite for mixture therapy of melanoma lung metastasis. Adv Healthc Mater. 2016;5:936–46.
Zhao Z, Li Y, Liu H, Jain A, Patel PV, Cheng Okay. Co-delivery of IKBKE SiRNA and Cabazitaxel by hybrid nanocomplex inhibits invasiveness and development of triple-negative breast most cancers. Sci Adv. 2020;6:eabb0616.
Zheng M, Tao W, Zou Y, Farokhzad OC, Shi B. Nanotechnology-Primarily based methods for SiRNA mind supply for illness remedy. Developments Biotechnol. 2018;36:562–75.
Zhang L, Wu T, Shan Y, Li G, Ni X, Chen X, Hu X, Lin L, Li Y, Guan Y, et al. Therapeutic reversal of Huntington’s illness by in vivo self-assembled SiRNAs. Mind. 2021;144:3421–35.
Zhang L, Hou S, Movahedi F, Li Z, Li L, Hu J, Jia Y, Huang Y, Zhu J, Solar X, et al. Amyloid-β/Tau burden and neuroinflammation dual-targeted nanomedicines synergistically restore reminiscence and recognition of Alzheimer’s illness mice. Nano Right this moment. 2023;49:101788.
Zhao Y, Qin J, Yu D, Liu Y, Track D, Tian Okay, Chen H, Ye Q, Wang X, Xu T, et al. Polymer-locking fusogenic liposomes for glioblastoma-targeted SiRNA supply and CRISPR-Cas gene enhancing. Nat Nanotechnol. 2024;19:1869–79.
Ahn I, Kang CS, Han J. The place ought to SiRNAs go: relevant organs for SiRNA medication. Exp Mol Med. 2023;55:1283–92.
Zhang Y, Ma H, Li L, Solar C, Yu C, Wang L, Xu D, Track X, Yu R. Twin-Focused novel Temozolomide nanocapsules encapsulating siPKM2 inhibit cardio Glycolysis to sensitize glioblastoma to chemotherapy. Adv Mater. 2024;36:e2400502.
Paramanantham A, Asfiya R, Das S, McCully G, Srivastava A. Extracellular vesicle (EVs) related Non-Coding RNAs in lung Most cancers and therapeutics. Int J Mol Sci. 2022;23.
Moro M, Di Paolo D, Milione M, Centonze G, Bornaghi V, Borzi C, Gandellini P, Perri P, Pastorino U, Ponzoni M, et al. Coated cationic lipid-nanoparticles entrapping miR-660 inhibit tumor development in patient-derived xenografts lung most cancers fashions. J Management Launch. 2019;308:44–56.
Peng Y, Zhu X, Qiu L. Electroneutral composite polymersomes self-assembled by amphiphilic polyphosphazenes for efficient miR-200c in vivo supply to inhibit drug resistant lung most cancers. Biomaterials. 2016;106:1–12.
Perepelyuk M, Maher C, Lakshmikuttyamma A, Shoyele SA. Aptamer-hybrid nanoparticle bioconjugate effectively delivers miRNA-29b to non-small-cell lung most cancers cells and inhibits development by downregulating important oncoproteins. Int J Nanomed. 2016;11:3533–44.
Mendonca MCP, Kont A, Aburto MR, Cryan JF, O’Driscoll CM. Advances within the design of (Nano)Formulations for supply of antisense oligonucleotides and small interfering RNA: give attention to the central nervous system. Mol Pharm. 2021;18:1491–506.
Crooke ST, Baker BF, Crooke RM, Liang XH. Antisense know-how: an outline and prospectus. Nat Rev Drug Discov. 2021;20:427–53.
Cheng X, Yu D, Cheng G, Yung BC, Liu Y, Li H, Kang C, Fang X, Tian S, Zhou X, et al. T7 Peptide-Conjugated lipid nanoparticles for twin modulation of Bcl-2 and Akt-1 in lung and cervical carcinomas. Mol Pharm. 2018;15:4722–32.
Lee SJ, Lim JH, Choi YH, Kim WJ, Moon SK. Interleukin-28A triggers wound therapeutic migration of bladder most cancers cells through NF-κB-mediated MMP-9 expression inducing the MAPK pathway. Cell Sign. 2012;24:1734–42.
Gong N, Teng X, Li J, Liang XJ. Antisense Oligonucleotide-Conjugated Nanostructure-Focusing on LncRNA MALAT1 inhibits Most cancers metastasis. ACS Appl Mater Interfaces. 2019;11:37–42.
Kawamura E, Hibino M, Harashima H, Yamada Y. Focused mitochondrial supply of antisense RNA-containing nanoparticles by a MITO-Porter for secure and environment friendly mitochondrial gene Silencing. Mitochondrion. 2019;49:178–88.
Lin B, Lu L, Wang Y, Zhang Q, Wang Z, Cheng G, Duan X, Zhang F, Xie M, Le H, et al. Nanomedicine directs neuronal differentiation of neural stem cells through Silencing lengthy noncoding RNA for stroke remedy. Nano Lett. 2021;21:806–15.
Chen L, Li G, Wang X, Li J, Zhang Y. Spherical nucleic acids for Close to-Infrared Mild-Responsive Self-Supply of Small-Interfering RNA and antisense oligonucleotide. ACS Nano. 2021;15:11929–39.
Agarwal C. A assessment: CRISPR/Cas12-mediated genome enhancing in fungal cells: developments, mechanisms, and future instructions in plant-fungal pathology. ScienceOpen Res. 2023.
Terns MP, Terns RM. CRISPR-based adaptive immune programs. Curr Opin Microbiol. 2011;14:321–7.
Jia Z, Zhang Y, Zhang C, Wei X, Zhang M. Biosensing intestinal alkaline phosphatase by being pregnant check strips based mostly on target-triggered CRISPR-Cas12a exercise to watch intestinal irritation. Anal Chem. 2023;95:14111–8.
Blanchard EL, Vanover D, Bawage SS, Tiwari PM, Rotolo L, Beyersdorf J, Peck HE, Bruno NC, Hincapie R, Michel F. Remedy of influenza and SARS-CoV-2 infections through mRNA-encoded Cas13a in rodents. Nat Biotechnol. 2021;39:717–26.
Harrington LB, Burstein D, Chen JS, Paez-Espino D, Ma E, Witte IP, Cofsky JC, Kyrpides NC, Banfield JF, Doudna JA. Programmed DNA destruction by miniature CRISPR-Cas14 enzymes. Science. 2018;362:839–42.
Ran FA, Hsu PD, Wright J, Agarwala V, Scott DA, Zhang F. Genome engineering utilizing the CRISPR-Cas9 system. Nat Protoc. 2013;8:2281–308.
Ran FA, Cong L, Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B, Shalem O, Wu X, Makarova KS, et al. In vivo genome enhancing utilizing Staphylococcus aureus Cas9. Nature. 2015;520:186–91.
Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, et al. CRISPR-Cas9 knockin mice for genome enhancing and most cancers modeling. Cell. 2014;159:440–55.
Hughes TS, Langer SJ, Virtanen SI, Chavez RA, Watkins LR, Milligan ED, Leinwand LA. Immunogenicity of intrathecal plasmid gene supply: cytokine launch and results on transgene expression. J Gene Med. 2009;11:782–90.
Zhang L, Wang P, Feng Q, Wang N, Chen Z, Huang Y, Zheng W, Jiang X. Lipid nanoparticle-mediated environment friendly supply of CRISPR/Cas9 for tumor remedy. NPG Asia Mater. 2017;9:e441–441.
Luo YL, Xu CF, Li HJ, Cao ZT, Liu J, Wang JL, Du XJ, Yang XZ, Gu Z, Wang J. Macrophage-Particular in vivo gene enhancing utilizing cationic Lipid-Assisted polymeric nanoparticles. ACS Nano. 2018;12:994–1005.
Luo YL, Liang LF, Gan YJ, Liu J, Zhang Y, Fan YN, Zhao G, Czarna A, Lu ZD, Du XJ, et al. An All-in-One nanomedicine consisting of CRISPR-Cas9 and an autoantigen peptide for restoring particular immune tolerance. ACS Appl Mater Interfaces. 2020;12:48259–71.
Yan X, Pan Q, Xin H, Chen Y, Ping Y. Genome-editing prodrug: focused supply and conditional stabilization of CRISPR-Cas9 for precision remedy of inflammatory illness. Sci Adv. 2021;7:eabj0624.
Wang P, Zhang L, Zheng W, Cong L, Guo Z, Xie Y, Wang L, Tang R, Feng Q, Hamada Y, et al. Thermo-triggered launch of CRISPR-Cas9 system by Lipid-Encapsulated gold nanoparticles for tumor remedy. Angew Chem Int Ed Engl. 2018;57:1491–6.
Zhu H, Zhang L, Tong S, Lee CM, Deshmukh H, Bao G. Spatial management of in vivo CRISPR-Cas9 genome enhancing through nanomagnets. Nat Biomed Eng. 2019;3:126–36.
Li J, Hao Y, Pan H, Zhang Y, Cheng G, Liu B, Chang J, Wang H. CRISPR-dcas9 optogenetic nanosystem for the blue Mild-Mediated therapy of neovascular lesions. ACS Appl Bio Mater. 2021;4:2502–13.
Li L, Yang Z, Zhu S, He L, Fan W, Tang W, Zou J, Shen Z, Zhang M, Tang L, et al. A rationally designed semiconducting polymer brush for NIR-II Imaging-Guided Mild-Triggered distant management of CRISPR/Cas9 genome enhancing. Adv Mater. 2019;31:e1901187.
Tang H, Xu X, Chen Y, Xin H, Wan T, Li B, Pan H, Li D, Ping Y. Reprogramming the tumor microenvironment by means of Second-Close to-Infrared-Window photothermal genome enhancing of PD-L1 mediated by supramolecular gold nanorods for enhanced Most cancers immunotherapy. Adv Mater. 2021;33:e2006003.
Alsaiari SK, Eshaghi B, Du B, Kanelli M, Li G, Wu X, Zhang L, Chaddah M, Lau A, Yang X, et al. CRISPR–Cas9 supply methods for the modulation of immune and non-immune cells. Nat Rev Mater. 2024;10:44–61.
Sahin U, Karikó Okay, Türeci Ö. mRNA-based therapeutics–growing a brand new class of medicine. Nat Rev Drug Discov. 2014;13:759–80.
Zhang X, Li B, Luo X, Zhao W, Jiang J, Zhang C, Gao M, Chen X, Dong Y. Biodegradable Amino-Ester nanomaterials for Cas9 mRNA supply in vitro and in vivo. ACS Appl Mater Interfaces. 2017;9:25481–7.
Liu S, Cheng Q, Wei T, Yu X, Johnson LT, Farbiak L, Siegwart DJ. Membrane-destabilizing ionizable phospholipids for organ-selective mRNA supply and CRISPR-Cas gene enhancing. Nat Mater. 2021;20:701–10.
Cheng Q, Wei T, Farbiak L, Johnson LT, Dilliard SA, Siegwart DJ. Selective organ concentrating on (SORT) nanoparticles for tissue-specific mRNA supply and CRISPR-Cas gene enhancing. Nat Nanotechnol. 2020;15:313–20.
Qiu M, Glass Z, Chen J, Haas M, Jin X, Zhao X, Rui X, Ye Z, Li Y, Zhang F, Xu Q. Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome enhancing of Angptl3. Proc Natl Acad Sci U S A. 2021;118.
Zhao Y, Li Y, Wang F, Gan X, Zheng T, Chen M, Wei L, Chen J, Yu C. CES1-Triggered Liver-Particular cargo launch of CRISPR/Cas9 components by cationic triadic copolymeric nanoparticles concentrating on gene enhancing of PCSK9 for hyperlipidemia amelioration. Adv Sci (Weinh). 2023;10:e2300502.
Rosenblum D, Gutkin A, Kedmi R, Ramishetti S, Veiga N, Jacobi AM, Schubert MS, Friedmann-Morvinski D, Cohen ZR, Behlke MA, et al. CRISPR-Cas9 genome enhancing utilizing focused lipid nanoparticles for most cancers remedy. Sci Adv. 2020;6.
Finn JD, Smith AR, Patel MC, Shaw L, Youniss MR, van Heteren J, Dirstine T, Ciullo C, Lescarbeau R, Seitzer J, et al. A single administration of CRISPR/Cas9 lipid nanoparticles achieves strong and chronic in vivo genome enhancing. Cell Rep. 2018;22:2227–35.
Gautam M, Jozic A, Su GL, Herrera-Barrera M, Curtis A, Arrizabalaga S, Tschetter W, Ryals RC, Sahay G. Lipid nanoparticles with PEG-variant floor modifications mediate genome enhancing within the mouse retina. Nat Commun. 2023;14:6468.
Yin H, Track CQ, Dorkin JR, Zhu LJ, Li Y, Wu Q, Park A, Yang J, Suresh S, Bizhanova A, et al. Therapeutic genome enhancing by mixed viral and non-viral supply of CRISPR system parts in vivo. Nat Biotechnol. 2016;34:328–33.
Miller JB, Zhang S, Kos P, Xiong H, Zhou Okay, Perelman SS, Zhu H, Siegwart DJ. Non-Viral CRISPR/Cas gene enhancing in vitro and in vivo enabled by artificial nanoparticle Co-Supply of Cas9 mRNA and SgRNA. Angewandte Chemie (Worldwide Ed English). 2017;56:1059–63.
Wei T, Cheng Q, Min YL, Olson EN, Siegwart DJ. Systemic nanoparticle supply of CRISPR-Cas9 ribonucleoproteins for efficient tissue particular genome enhancing. Nat Commun. 2020;11:3232.
Chang J, Chen X, Glass Z, Gao F, Mao L, Wang M, Xu Q. Integrating combinatorial lipid nanoparticle and chemically modified protein for intracellular supply and genome enhancing. Acc Chem Res. 2019;52:665–75.
Park H, Oh J, Shim G, Cho B, Chang Y, Kim S, Baek S, Kim H, Shin J, Choi H, et al. In vivo neuronal gene enhancing through CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse fashions of Alzheimer’s illness. Nat Neurosci. 2019;22:524–8.
Alsaiari SK, Patil S, Alyami M, Alamoudi KO, Aleisa FA, Merzaban JS, Li M, Khashab NM. Endosomal escape and supply of CRISPR/Cas9 genome enhancing equipment enabled by nanoscale zeolitic imidazolate framework. J Am Chem Soc. 2018;140:143–6.
Wan T, Chen Y, Pan Q, Xu X, Kang Y, Gao X, Huang F, Wu C, Ping Y. Genome enhancing of mutant KRAS by means of supramolecular polymer-mediated supply of Cas9 ribonucleoprotein for colorectal most cancers remedy. J Management Launch. 2020;322:236–47.
Lee Okay, Conboy M, Park HM, Jiang F, Kim HJ, Dewitt MA, Mackley VA, Chang Okay, Rao A, Skinner C, et al. Nanoparticle supply of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA restore. Nat Biomed Eng. 2017;1:889–901.
Liu C, Wan T, Wang H, Zhang S, Ping Y, Cheng Y. A boronic acid-rich dendrimer with strong and unprecedented effectivity for cytosolic protein supply and CRISPR-Cas9 gene enhancing. Sci Adv. 2019;5:eaaw8922.
Deng S, Li X, Liu S, Chen J, Li M, Chew SY, Leong KW, Cheng D. Codelivery of CRISPR-Cas9 and Chlorin e6 for spatially managed tumor-specific gene enhancing with synergistic drug results. Sci Adv. 2020;6:eabb4005.
Nguyen DN, Roth TL, Li PJ, Chen PA, Apathy R, Mamedov MR, Vo LT, Tobin VR, Goodman D, Shifrut E, et al. Polymer-stabilized Cas9 nanoparticles and modified restore templates enhance genome enhancing effectivity. Nat Biotechnol. 2020;38:44–9.
Lee J, Kang YK, Oh E, Jeong J, Im SH, Kim DK, Lee H, Kim S-G, Jung Okay, Chung HJ. Nano-assembly of a chemically tailor-made Cas9 ribonucleoprotein for in vivo gene enhancing and Most cancers immunotherapy. Chem Mater. 2022;34:547–61.
Ho TC, Kim HS, Chen Y, Li Y, LaMere MW, Chen C, Wang H, Gong J, Palumbo CD, Ashton JM, et al. Scaffold-mediated CRISPR-Cas9 supply system for acute myeloid leukemia remedy. Sci Adv. 2021;7:eabg3217.
Wan T, Pan Q, Ping Y. Microneedle-assisted genome enhancing: A transdermal technique of concentrating on NLRP3 by CRISPR-Cas9 for synergistic remedy of inflammatory pores and skin issues. Sci Adv. 2021;7:eabe2888.
Liu Q, Wang C, Zheng Y, Zhao Y, Wang Y, Hao J, Zhao X, Yi Okay, Shi L, Kang C, Liu Y. Virus-like nanoparticle as a co-delivery system to reinforce efficacy of CRISPR/Cas9-based most cancers immunotherapy. Biomaterials. 2020;258:120275.
Pan Y, Yang J, Luan X, Liu X, Li X, Yang J, Huang T, Solar L, Wang Y, Lin Y, Track Y. Close to-infrared upconversion-activated CRISPR-Cas9 system: A remote-controlled gene enhancing platform. Sci Adv. 2019;5:eaav7199.
Chen X, Chen Y, Xin H, Wan T, Ping Y. Close to-infrared optogenetic engineering of photothermal NanoCRISPR for programmable genome enhancing. Proc Natl Acad Sci U S A. 2020;117:2395–405.
Peng LH, Wang MZ, Chu Y, Zhang L, Niu J, Shao HT, Yuan TJ, Jiang ZH, Gao JQ, Ning XH. Engineering bacterial outer membrane vesicles as transdermal nanoplatforms for photo-TRAIL-programmed remedy in opposition to melanoma. Sci Adv. 2020;6:eaba2735.
Wang M, Yan G, Xiao Q, Zhou N, Chen H-R, Xia W, Peng L. Iontophoresis-driven microneedle arrays delivering Transgenic outer membrane vesicles in program that stimulates transcutaneous vaccination for Most cancers immunotherapy. Small Sci. 2023;3.
Zhao M, Cheng X, Shao P, Dong Y, Wu Y, Xiao L, Cui Z, Solar X, Gao C, Chen J, et al. Bacterial protoplast-derived nanovesicles carrying CRISPR-Cas9 instruments re-educate tumor-associated macrophages for enhanced most cancers immunotherapy. Nat Commun. 2024;15:950.
Westin J, Sehn LH. CAR T cells as a second-line remedy for big B-cell lymphoma: a paradigm shift? Blood J Am Soc Hematol. 2022;139:2737–46.
Pan Okay, Farrukh H, Chittepu VCSR, Xu H, Pan C-x, Zhu Z. CAR race to most cancers immunotherapy: from CAR T, CAR NK to CAR macrophage remedy. J Exp Clin Most cancers Res. 2022;41:119.
Sheykhhasan M, Manoochehri H, Dama P. Use of CAR T-cell for acute lymphoblastic leukemia (ALL) therapy: a assessment research. Most cancers Gene Ther. 2022;29:1080–96.
Bucher P, Feucht J. LINKing signaling domains to reinforce CAR T cells. Nat Most cancers. 2023;4:447–9.
Hu Y, Zhou Y, Zhang M, Zhao H, Wei G, Ge W, Cui Q, Mu Q, Chen G, Han L, et al. Genetically modified CD7-targeting allogeneic CAR-T cell remedy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a part I scientific research. Cell Res. 2022;32:995–1007.
Smith TT, Stephan SB, Moffett HF, McKnight LE, Ji W, Reiman D, Bonagofski E, Wohlfahrt ME, Pillai SPS, Stephan MT. In situ programming of leukaemia-specific T cells utilizing artificial DNA nanocarriers. Nat Nanotechnol. 2017;12:813–20.
Zhang X, Su Okay, Wu S, Lin L, He S, Yan X, Shi L, Liu S. One-Part cationic lipids for systemic mRNA supply to Splenic T cells. Angew Chem Int Ed Engl. 2024;63:e202405444.
Olden BR, Cheng Y, Yu JL, Pun SH. Cationic polymers for non-viral gene supply to human T cells. J Management Launch. 2018;282:140–7.
Billingsley MM, Singh N, Ravikumar P, Zhang R, June CH, Mitchell MJ. Ionizable lipid Nanoparticle-Mediated mRNA supply for human CAR T cell engineering. Nano Lett. 2020;20:1578–89.
Billingsley MM, Hamilton AG, Mai D, Patel SK, Swingle KL, Sheppard NC, June CH, Mitchell MJ. Orthogonal design of experiments for optimization of lipid nanoparticles for mRNA engineering of CAR T cells. Nano Lett. 2022;22:533–42.
Parayath NN, Stephan SB, Koehne AL, Nelson PS, Stephan MT. In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in Circulating T cells in vivo. Nat Commun. 2020;11:6080.
McEvoy E, Han YL, Guo M, Shenoy VB. Hole junctions amplify Spatial variations in cell quantity in proliferating tumor spheroids. Nat Commun. 2020;11:6148.
He X, Xu C. Immune checkpoint signaling and most cancers immunotherapy. Cell Res. 2020;30:660–9.
Tang L, Zheng Y, Melo MB, Mabardi L, Castano AP, Xie YQ, Li N, Kudchodkar SB, Wong HC, Jeng EK, et al. Enhancing T cell remedy by means of TCR-signaling-responsive nanoparticle drug supply. Nat Biotechnol. 2018;36:707–16.
Zhang F, Stephan SB, Ene CI, Smith TT, Holland EC, Stephan MT. Nanoparticles that reshape the tumor milieu create a therapeutic window for efficient T-cell remedy in stable malignancies. Most cancers Res. 2018;78:3718–30.
Tang L, Pan S, Wei X, Xu X, Wei Q. Arming CAR-T cells with cytokines and extra: improvements within the fourth-generation CAR-T improvement. Mol Ther. 2023;31:3146–62.
Uslu U, Castelli S, June CH. CAR T cell mixture therapies to deal with most cancers. Most cancers Cell. 2024;42:1319–25.
Zhu T, Xiao Y, Chen Z, Ding H, Chen S, Jiang G, Huang X. Inhalable nanovesicles loaded with a STING agonist improve CAR-T cell exercise in opposition to stable tumors within the lung. Nat Commun. 2025;16:262.
Solar Y, Sha Y, Cui G, Meng F, Zhong Z. Lysosomal-mediated drug launch and activation for most cancers remedy and immunotherapy. Adv Drug Deliv Rev. 2023;192:114624.
Chen Z, Pan H, Luo Y, Yin T, Zhang B, Liao J, Wang M, Tang X, Huang G, Deng G, et al. Nanoengineered CAR-T biohybrids for stable tumor immunotherapy with microenvironment Photothermal-Transforming technique. Small. 2021;17:e2007494.
Xiong R, Hua D, Van Hoeck J, Berdecka D, Leger L, De Munter S, Fraire JC, Raes L, Harizaj A, Sauvage F, et al. Photothermal nanofibres allow secure engineering of therapeutic cells. Nat Nanotechnol. 2021;16:1281–91.
Jeong M, Lee Y, Park J, Jung H, Lee H. Lipid nanoparticles (LNPs) for in vivo RNA supply and their breakthrough know-how for future functions. Adv Drug Deliv Rev. 2023;200:114990.
Namiot ED, Sokolov AV, Chubarev VN, Tarasov VV, Schiöth HB. Nanoparticles in scientific trials: evaluation of scientific trials, FDA approvals and use for COVID-19 vaccines. Int J Mol Sci. 2023;24.
Salvioni L, Rizzuto MA, Bertolini JA, Pandolfi L, Colombo M, Prosperi D. Thirty years of Most cancers nanomedicine: success, frustration, and hope. Cancers (Basel). 2019;11.
A Section 1, Open-Label, multicenter research to evaluate the security and tolerability of mRNA-5671/V941 as a monotherapy and together with pembrolizumab in individuals with KRAS mutant superior or metastatic Non-Small cell lung most cancers, colorectal Most cancers or pancreatic adenocarcinoma. (ModernaTx I ed.; 2019).
Single-Arm A. Open-Label, exploratory research to guage the security of RNA tumor vaccine injection alone/together with PD-1 inhibitor within the therapy of superior stable tumors with KRAS mutation. 2022.
A Section 1, Open-Label, multicenter, dose escalation research of mRNA-2752, a lipid nanoparticle encapsulating mRNAs encoding human OX40L, IL-23, and IL-36γ, for intratumoral injection alone and together with immune checkpoint Blockade. (AstraZeneca ed.; 2018).
Section A, Ib Open-Label I. Multi-Middle, Dose-Escalation research to research the security, pharmacokinetics and preliminary efficacy of intravenous NBF 006 in sufferers with Non-Small cell lung, pancreatic, or colorectal Most cancers adopted by a dose enlargement research in sufferers with KRAS-Mutated Non-Small cell lung Most cancers. 2019.
Potential A. Open-label, single middle, dose discovering part I-study with Atu027 (an SiRNA Formulation) in topics with superior stable Most cancers. 2009.
EphA2 Gene Focusing on Utilizing Impartial Liposomal Small Interfering RNA Supply. A Section I Medical Trial. (Gateway for Most cancers R, Institutional Funding for Federally Supported Medical T, Nationwide Most cancers I eds.); 2012.
Multicenter Section A. I Research of MRX34, MicroRNA miR-RX34 liposomal injection. Most cancers Prevention Analysis Institute of T ed.; 2013.
Section A. I, Dose-Escalating research of the security of intravenous CALAA-01 in adults with stable tumors refractory to Commonplace-of-Care therapies. 2008.
Section I. Research of mesenchymal stromal Cells-Derived exosomes with KrasG12D SiRNA for metastatic pancreas Most cancers sufferers harboring KrasG12D mutation. 2018.
Halwani AA. Growth of pharmaceutical nanomedicines: from the bench to the market. Pharmaceutics 2022, 14.
Das RP, Gandhi VV, Singh BG, Kunwar A. Passive and energetic drug concentrating on: position of nanocarriers in rational design of anticancer formulations. Curr Pharm Des. 2019;25:3034–56.
Broncy L, Paterlini-Bréchot P. Medical influence of Circulating tumor cells in sufferers with localized prostate most cancers. Cells. 2019;8:676.
Zhang X, Guo Q, Cui D. Latest advances in nanotechnology utilized to biosensors. Sensors. 2009;9:1033–53.
Wahab S, Alshahrani MY, Ahmad MF, Abbas H. Present developments and future views of nanomedicine for the administration of colon most cancers. Eur J Pharmacol. 2021;910:174464.
Qin J, Gong N, Liao Z, Zhang S, Timashev P, Huo S, Liang X-J. Latest progress in mitochondria-targeting-based nanotechnology for most cancers therapy. Nanoscale. 2021;13:7108–18.
Lv Okay, Yu Z, Wang J, Li N, Wang A, Xue T, Wang Q, Shi Y, Han L, Qin W, et al. Discovery of Ketal-Ester ionizable lipid nanoparticle with decreased hepatotoxicity, enhanced spleen tropism for mRNA vaccine supply. Adv Sci (Weinh). 2024;11:e2404684.
Patil SM, Daram A, Kunda NK. 3D spheroid mannequin reveals enhanced efficacy of mannose-decorated nanoparticles for TB therapy. Nanomed (Lond). 2025;20:777–89.
Ou BS, Baillet J, Picece V, Gale EC, Powell AE, Saouaf OM, Yan J, Nejatfard A, Lopez Hernandez H, Appel EA. Nanoparticle-Conjugated Toll-Like receptor 9 agonists enhance the efficiency, sturdiness, and breadth of COVID-19 vaccines. ACS Nano. 2024;18:3214–33.
Lee E, Jeon H, Lee M, Ryu J, Kang C, Kim S, Jung J, Kwon Y. Molecular origin of AuNPs-induced cytotoxicity and mechanistic research. Sci Rep. 2019;9:2494.
Dong JH, Ma Y, Li R, Zhang WT, Zhang MQ, Meng FN, Ding Okay, Jiang HT, Gong YK. Good MSN-Drug-Supply system for tumor cell concentrating on and tumor microenvironment launch. ACS Appl Mater Interfaces. 2021;13:42522–32.
Wong TY, Yan N, Kwan KKL, Pan Y, Liu J, Xiao Y, Wu L, Lam H. Comparative proteomic evaluation reveals the totally different hepatotoxic mechanisms of human hepatocytes uncovered to silver nanoparticles. J Hazard Mater. 2023;445:130599.
Sharma A, Sah N, Kannan S, Kannan RM. Focused drug supply for maternal and perinatal well being: challenges and alternatives. Adv Drug Deliv Rev. 2021;177:113950.
Wang J, Huang H, Jia M, Chen S, Wang F, He G, Wu C, Lou Okay, Zheng X, Zhang H, et al. Autologous platelet supply of SiRNAs by autologous plasma protein self-assembled nanoparticles for the therapy of acute kidney damage. J Nanobiotechnol. 2025;23:256.
Yong H, Tian Y, Li Z, Wang C, Zhou D, Liu J, Huang X, Li J. Extremely branched Poly(β-amino ester)s for environment friendly mRNA supply and nebulization therapy of silicosis. Adv Mater 2025:e2414991.
Jakic Okay, Selc M, Razga F, Nemethova V, Mazancova P, Havel F, Sramek M, Zarska M, Proska J, Masanova V, et al. Lengthy-Time period accumulation, organic results and toxicity of BSA-Coated gold nanoparticles within the mouse liver, spleen, and kidneys. Int J Nanomed. 2024;19:4103–20.
Hashem A, Jaentschke B, Gravel C, Tocchi M, Doyle T, Rosu-Myles M, He R, Li X. Subcutaneous immunization with Recombinant adenovirus expressing influenza A nucleoprotein protects mice in opposition to deadly viral problem. Hum Vaccin Immunother. 2012;8:425–30.
Dobrovolskaia MA, Aggarwal P, Corridor JB, McNeil SE. Preclinical research to know nanoparticle interplay with the immune system and its potential results on nanoparticle biodistribution. Mol Pharm. 2008;5:487–95.
Yu Okay, Fu L, Chao Y, Zeng X, Zhang Y, Chen Y, Gao J, Lu B, Zhu H, Gu L, et al. Deep studying enhanced close to Infrared-II imaging and Picture-Guided small interfering ribonucleic acid remedy of ischemic stroke. ACS Nano. 2025;19:10323–36.
Guo S, Agarwal T, Track S, Sarkar Okay, Zhang LG. Growth of novel multi-responsive 4D printed sensible nanocomposites with polypyrrole coated iron oxides for distant and adaptive transformation. Mater Horiz 2025.
Störtz F, Minary P. CrisprSQL: a novel database platform for CRISPR/Cas off-target cleavage assays. Nucleic Acids Res. 2021;49:D855–61.
Grünewald J, Zhou R, Garcia SP, Iyer S, Lareau CA, Aryee MJ, Joung JK. Transcriptome-wide off-target RNA enhancing induced by CRISPR-guided DNA base editors. Nature. 2019;569:433–7.
Naeem M, Hoque MZ, Ovais M, Basheer C, Ahmad I. Stimulus-Responsive sensible Nanoparticles-Primarily based CRISPR-Cas supply for therapeutic genome enhancing. Int J Mol Sci. 2021;22.
You S, Zuo L, Li W. Optimizing the time of doxil injection to extend the drug retention in transplanted murine mammary tumors. Int J Nanomed. 2010;5:221–9.
Baeza A. Tumor focused nanocarriers for immunotherapy. Molecules 2020, 25.
Wagner J, Gößl D, Ustyanovska N, Xiong M, Hauser D, Zhuzhgova O, Hočevar S, Taskoparan B, Poller L, Datz S, et al. Mesoporous silica nanoparticles as pH-Responsive provider for the immune-Activating drug resiquimod improve the native immune response in mice. ACS Nano. 2021;15:4450–66.
Khan SN, Han P, Chaudhury R, Bickerton S, Lee JS, Calderon B, Pellowe A, Gonzalez A, Fahmy T. Direct comparability of B cell floor receptors as therapeutic targets for nanoparticle supply of BTK inhibitors. Mol Pharm. 2021;18:850–61.
Yu X, Dai Y, Zhao Y, Qi S, Liu L, Lu L, Luo Q, Zhang Z. Melittin-lipid nanoparticles goal to lymph nodes and elicit a systemic anti-tumor immune response. Nat Commun. 2020;11:1110.
Tao J, Fei W, Tang H, Li C, Mu C, Zheng H, Li F, Zhu Z. Angiopep-2-Conjugated Core-Shell hybrid nanovehicles for focused and pH-Triggered supply of arsenic trioxide into glioma. Mol Pharm. 2019;16:786–97.
Yu X, Yu C, Wu X, Cui Y, Liu X, Jin Y, Li Y, Wang L. Validation of an HPLC-CAD methodology for dedication of lipid content material in LNP-Encapsulated COVID-19 mRNA vaccines. Vaccines (Basel). 2023;11.
Yu J, Li Q, Zhang C, Wang Q, Luo S, Wang X, Hu R, Cheng Q. Focused LNPs ship IL-15 superagonists mRNA for precision most cancers remedy. Biomaterials. 2025;317:123047.
Xie R, Wang X, Wang Y, Ye M, Zhao Y, Yandell BS, Gong S. pH-Responsive polymer nanoparticles for environment friendly supply of Cas9 ribonucleoprotein with or with out donor DNA. Adv Mater. 2022;34:2110618.
Donahue ND, Acar H, Wilhelm S. Ideas of nanoparticle mobile uptake, intracellular trafficking, and kinetics in nanomedicine. Adv Drug Deliv Rev. 2019;143:68–96.
Akinc A, Querbes W, De S, Qin J, Frank-Kamenetsky M, Jayaprakash KN, Jayaraman M, Rajeev KG, Cantley WL, Dorkin JR, et al. Focused supply of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. Mol Ther. 2010;18:1357–64.
Tang J, Zhang L, Gao H, Liu Y, Zhang Q, Ran R, Zhang Z, He Q. Co-delivery of doxorubicin and P-gp inhibitor by a reduction-sensitive liposome to beat multidrug resistance, improve anti-tumor effectivity and cut back toxicity. Drug Deliv. 2016;23:1130–43.
Patil V, Patel A. Biodegradable nanoparticles: A latest strategy and functions. Curr Drug Targets. 2020;21:1722–32.
