Contaminated wounds pose a big medical problem, primarily because of a hostile microenvironment characterised by persistent oxidative stress, bacterial an infection, and disrupted tissue regeneration. Herein, we developed a biomimetic nanoclay-based hydrogel composed of MnO2@montmorillonite/chitosan (MnO2@MMT/CS), designed to comprehensively transform this pathological area of interest. Past serving as a structural scaffold, the nanoclay MMT acts as an digital modulator that optimizes the catalytic exercise of MnO2, enabling environment friendly reactive oxygen species (ROS) scavenging by way of superoxide dismutase (SOD)- and catalase (CAT)-like cascade reactions. Integrated right into a chitosan matrix, the nanocomposite replicates the three-dimensional hydrous structure of the native extracellular matrix (ECM). Beneath near-infrared (NIR) irradiation, the hydrogel reveals potent photothermal antibacterial exercise. In vitro assessments demonstrated wonderful biocompatibility and enhanced cell migration, whereas in vivo research on contaminated wound fashions revealed accelerated wound closure, promoted collagen deposition, and improved tissue regeneration, with negligible systemic toxicity. Taken collectively, the MnO2@MMT/CS hydrogel represents a multifunctional microenvironment regulator, attaining synergistic antioxidant, antibacterial, and pro-regenerative outcomes for efficient wound administration.