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A trimer ancestral spike-based mRNA vaccine confers cross-generational safety in opposition to SADS-CoV | Journal of Nanobiotechnology


  • Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol. 2019;17:181–92.

    Article 
    PubMed 

    Google Scholar
     

  • Le NP, Le BT, Le VP, Park JE. Molecular characterization of swine acute diarrhea syndrome coronavirus detected in Vietnamese pigs. Vet Res. 2025;56:4.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rajkhowa S, Sonowal J, Pegu SR, Deb R, Gupta VK. Epidemiology and rising traits of zoonotic viral ailments of pigs in India. Viruses. 2025;17(3):381. https://doi.org/10.3390/v17030381.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhou P, Fan H, Lan T, Yang XL, Shi WF, Zhang W, et al. Deadly swine acute diarrhoea syndrome brought on by an HKU2-related coronavirus of bat origin. Nature. 2018;556:255–8.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li Ok, Li H, Bi Z, Gu J, Gong W, Luo S, et al. Full genome sequence of a novel swine acute diarrhea syndrome coronavirus, CH/FJWT/2018, remoted in Fujian, China, in 2018. Microbiol Resour Announc. 2018. https://doi.org/10.1128/mra.01259-18.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xu Z, Zhang Y, Gong L, Huang L, Lin Y, Qin J, et al. Isolation and characterization of a extremely pathogenic pressure of Porcine enteric alphacoronavirus inflicting watery diarrhoea and excessive mortality in new child piglets. Transbound Emerg Dis. 2019;66:119–30.

    Article 
    PubMed 

    Google Scholar
     

  • Yan Q, Liu X, Solar Y, Zeng W, Li Y, Zhao F, et al. Swine enteric coronavirus: various pathogen-host interactions. Int J Mol Sci. 2022. https://doi.org/10.3390/ijms23073953.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Edwards CE, Yount BL, Graham RL, Leist SR, Hou YJ, Dinnon KH third, et al. Swine acute diarrhea syndrome coronavirus replication in main human cells reveals potential susceptibility to an infection. Proc Natl Acad Sci U S A. 2020;117:26915–25.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wickenhagen A, van Tol S, Munster V. Molecular determinants of cross-species transmission in rising viral infections. Microbiol Mol Biol Rev. 2024;88:e0000123.

    Article 
    PubMed 

    Google Scholar
     

  • Si F, Yu R, Dong S, Chen B, Li C, Music S. In the direction of a safer future: enhancing vaccine growth to fight animal coronaviruses. Vaccines. 2024. https://doi.org/10.3390/vaccines12030330.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mao L, Cai X, Li J, Li X, Li S, Li W, et al. Discovery of a novel Betacoronavirus 1, cpCoV, in goats in China: the brand new danger of cross-species transmission. PLoS Pathog. 2025;21:e1012974.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang Z, Mateus J, Coelho CH, Dan JM, Moderbacher CR, Galvez RI, et al. Humoral and mobile immune reminiscence to 4 COVID-19 vaccines. Cell. 2022;185:2434–51.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • van de Ven Ok, Lanfermeijer J, van Dijken H, Muramatsu H, Boas V, de Melo C, et al. A common influenza mRNA vaccine candidate boosts T cell responses and reduces zoonotic influenza virus illness in ferrets. Sci Adv. 2022;8:eadc9937.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Duan Y, Yuan C, Suo X, Li Y, Shi L, Cao L, et al. Bat-origin swine acute diarrhea syndrome coronavirus is deadly to neonatal mice. J Virol. 2023;97:e0019023.

    Article 
    PubMed 

    Google Scholar
     

  • Shin H, Kang S, Received C, Min DH. A single-dose mrna vaccine using porous silica nanoparticles induces sturdy immune responses in opposition to the Zika virus. Adv Sci (Weinh). 2024;11:e2404590.

    Article 
    PubMed 

    Google Scholar
     

  • Cho SW, Shin SC, Nam Y, Ahn HJ. A T7 autogene-mediated DNA vaccine platform for SARS-CoV-2: overcoming DNA vaccine limitations with enhanced spike mRNA manufacturing. J Management Launch. 2025;383:113776.

    Article 
    PubMed 

    Google Scholar
     

  • Trieu MC, Reynaldi A, Lee WS, Tan HX, Kelly A, Esterbauer R, et al. Bivalent mRNA booster vaccination recollects mobile and antibody immunity in opposition to antigenically divergent SARS-CoV-2 spike antigens. NPJ Vaccines. 2025;10:74.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang Z, Tian C, Zhu J, Wang S, Ao X, He Y, et al. Avian influenza mRNA vaccine encoding hemagglutinin offers full safety in opposition to divergent H5N1 viruses in specific-pathogen-free chickens. J Nanobiotechnol. 2025;23:55.

    Article 

    Google Scholar
     

  • Ling J, Chen H, Huang M, Wang J, Du X. An mRNA vaccine encoding proteasome-targeted antigen enhances CD8(+) T cell immunity. J Management Launch. 2025;381:113578.

    Article 
    PubMed 

    Google Scholar
     

  • Broomfield BJ, Tan CW, Qin RZ, Abberger H, Duckworth BC, Alvarado C, et al. Transient inhibition of kind I interferon enhances CD8+ T cell stemness and vaccine safety. J Exp Med. 2025. https://doi.org/10.1084/jem.20241148.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Priest DG, Ebihara T, Tulyeu J, Sondergaard JN, Sakakibara S, Sugihara F, et al. Atypical and non-classical CD45RB(lo) reminiscence B cells are nearly all of circulating SARS-CoV-2 particular B cells following mRNA vaccination or COVID-19. Nat Commun. 2024;15:6811.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Girard B, Figueroa AL, De Rosa SC, McElrath MJ, Azzi JR, Stolman D, et al. mRNA-1273 COVID-19 vaccine induces CD4+ T-cell responses amongst strong organ transplant recipients. Entrance Immunol. 2025;16:1505871.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang R, Huang H, Yu C, Solar C, Ma J, Kong D, et al. A spike-trimer protein-based tetravalent COVID-19 vaccine elicits enhanced breadth of neutralization in opposition to SARS-CoV-2 Omicron subvariants and different variants. Sci China Life Sci. 2023;66:1818–30.

    Article 
    PubMed 

    Google Scholar
     

  • Marcos-Villar L, Perdiguero B, Anthiya S, Borrajo ML, Lou G, Franceschini L, et al. Modulating the immune response to SARS-CoV-2 by totally different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA consortium. NPJ Vaccines. 2024;9:53.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Marcos-Villar L, Perdiguero B, Lopez-Bravo M, Zamora C, Sin L, Alvarez E, et al. Heterologous mRNA/MVA delivering trimeric-RBD as efficient vaccination routine in opposition to SARS-CoV-2: covarna consortium. Emerg Microbes Infect. 2024;13:2387906.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhao Y, Fan B, Music X, Gao J, Guo R, Yi C, He Z, Hu H, Jiang J, Zhao L, et al. PEDV-spike-protein-expressing mRNA vaccine protects piglets in opposition to PEDV problem. mBio 2024;15:e0295823.

  • Goel RR, Painter MM, Apostolidis SA, Mathew D, Meng W, Rosenfeld AM, et al. mRNA vaccines induce sturdy immune reminiscence to SARS-CoV-2 and variants of concern. Science. 2021;374:abm0829.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ananworanich J, Lee IT, Ensz D, Carmona L, Schaefers Ok, Avanesov A, et al. Security and immunogenicity of mRNA-1010, an investigational seasonal influenza vaccine, in wholesome adults: closing outcomes from a part 1/2 randomized trial. J Infect Dis. 2025;231:e113–22.

    Article 
    PubMed 

    Google Scholar
     

  • Lee YS, Cheong MS, Lee J, Bang EK, Park SI, Park HJ, et al. Immunogenicity and safety of a triple repeat area III mRNA vaccine in opposition to Zika virus. Vaccine. 2025;43:126518.

    Article 
    PubMed 

    Google Scholar
     

  • Liu X. Alternatives and challenges of mRNA applied sciences in growth of dengue virus vaccine. Entrance Immunol. 2025;16:1520968.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Patra T, Meyer Ok, Haga Y, Reagan EK, Weissman D, Ray R. Hepatitis C virus E1 and modified E2 delivered from an mrna vaccine induces protecting immunity. NPJ Vaccines. 2023;8:42.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zubair A, Ahmad H, Arif MM, Ali M. mRNA vaccines in opposition to HIV: hopes and challenges. HIV Med. 2025. https://doi.org/10.1111/hiv.70024.

    Article 
    PubMed 

    Google Scholar
     

  • Wang Q, Vlasova AN, Kenney SP, Saif LJ. Rising and re-emerging coronaviruses in pigs. Curr Opin Virol. 2019;34:39–49.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liang J, Xu W, Pan X, Han S, Zhang L, Wen H, et al. Advances analysis in porcine enteric coronavirus therapies and antiviral medication. Vet Q. 2024;44:1–49.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Thakor JC, Dinesh M, Manikandan R, Bindu S, Sahoo M, Sahoo D, et al. Swine coronaviruses (SCoVs) and their rising threats to swine inhabitants, inter-species transmission, exploring the susceptibility of pigs for SARS-CoV-2 and zoonotic issues. Vet Q. 2022;42:125–47.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guo J, Lai Y, Yang Z, Music W, Zhou J, Li Z, et al. Coinfection and nonrandom recombination drive the evolution of swine enteric coronaviruses. Emerg Microbes Infect. 2024;13:2332653.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kong F, Jia H, Xiao Q, Fang L, Wang Q. Prevention and management of Swine enteric coronaviruses in China: a evaluate of vaccine growth and software. Vaccines. 2023. https://doi.org/10.3390/vaccines12010011.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Qu W, Sui L, Li Y. Vaccine escape challenges virus prevention: the instance of two vaccine-preventable oncogenic viruses. J Med Virol. 2023;95:e29184.

    Article 
    PubMed 

    Google Scholar
     

  • Chakraborty C, Sharma AR, Bhattacharya M, Lee SS. An in depth overview of immune escape, antibody escape, partial vaccine escape of SARS-CoV-2 and their rising variants with escape mutations. Entrance Immunol. 2022;13:801522.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Moustsen-Helms IR, Bager P, Larsen TG, Moller FT, Vestergaard LS, Rasmussen M, et al. Relative vaccine safety, illness severity, and signs related to the SARS-CoV-2 omicron subvariant BA.2.86 and descendant JN.1 in Denmark: a nationwide observational examine. Lancet Infect Dis. 2024;24:964–73.

    Article 
    PubMed 

    Google Scholar
     

  • Musil M, Khan RT, Beier A, Stourac J, Konegger H, Damborsky J, et al. Fireprotasr: an online server for absolutely automated ancestral sequence reconstruction. Temporary Bioinform. 2021. https://doi.org/10.1093/bib/bbaa337.

    Article 
    PubMed 

    Google Scholar
     

  • Jowkar G, Pecerska J, Maiolo M, Gil M, Anisimova M. ARPIP: ancestral sequence reconstruction with insertions and deletions beneath the Poisson indel course of. Syst Biol. 2023;72:307–18.

    Article 
    PubMed 

    Google Scholar
     

  • Randall RN, Radford CE, Roof KA, Natarajan DK, Gaucher EA. An experimental phylogeny to benchmark ancestral sequence reconstruction. Nat Commun. 2016;7:12847.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li J, Xiao L, Chen Z, Fan L, Wang W, Guo R, et al. A spike-based mRNA vaccine that induces sturdy and broad safety in opposition to porcine deltacoronavirus in piglets. J Virol. 2024;98:e0053524.

    Article 
    PubMed 

    Google Scholar
     

  • Murat P, Tellam J. Results of messenger RNA construction and different translational management mechanisms on main histocompatibility complex-I mediated antigen presentation. WIREs RNA. 2015;6:157–71.

    Article 
    PubMed 

    Google Scholar
     

  • Fernandes RS, de Assis B-C, Sergio SAR, Braz AF, da Silva Leite NP, Pereira M, et al. The immunogenic potential of an optimized mRNA lipid nanoparticle formulation carrying sequences from virus and protozoan antigens. J Nanobiotechnology. 2025;23:221.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lavelle EC, Ward RW. Mucosal vaccines – fortifying the frontiers. Nat Rev Immunol. 2022;22:236–50.

    Article 
    PubMed 

    Google Scholar
     

  • Liu L, Liu Z, Chen H, Liu H, Gao Q, Cong F, et al. Subunit nanovaccine with potent mobile and mucosal immunity for COVID-19. ACS Appl Bio Mater. 2020;3:5633–8.

    Article 
    PubMed 

    Google Scholar
     

  • Li M, Wang W, Chen J, Zhan Z, Xu M, Liu N, et al. Transplacental switch effectivity of maternal antibodies in opposition to influenza A(H1N1)pdm09 virus and dynamics of naturally acquired antibodies in Chinese language youngsters: a longitudinal, paired mother-neonate cohort examine. Lancet Microbe. 2023;4:e893–902.

    Article 
    PubMed 

    Google Scholar
     

  • Callender M, Harvill ET. Maternal vaccination: shaping the neonatal response to pertussis. Entrance Immunol. 2023;14:1210580.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cankat S, Demael MU, Swadling L. Seeking a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms. Cell Mol Immunol. 2024;21:103–18.

    Article 
    PubMed 

    Google Scholar
     

  • Guo L, Lin S, Chen Z, Cao Y, He B, Lu G. Targetable parts in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines. Sign Transduct Goal Ther. 2023;8:197.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li L, Zhou H. Improvement of an all-in-one pan-sarbecovirus ferritin nanoparticle vaccine in people. Lancet Microbe. 2025;6:100974.

    Article 
    PubMed 

    Google Scholar
     

  • Liu Z, Zhou J, Wang X, Xu W, Teng Z, Chen H, et al. A pan-sarbecovirus vaccine primarily based on RBD of SARS-CoV-2 unique pressure elicits potent neutralizing antibodies in opposition to XBB in non-human primates. Proc Natl Acad Sci USA. 2023;120:e2221713120.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rosen LE, Tortorici MA, De Marco A, Pinto D, Foreman WB, Taylor AL, et al. A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification. Cell. 2024;187:7196–213.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Case JB, Sanapala S, Dillen C, Rhodes V, Zmasek C, Chicz TM, et al. A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus safety in mice. Cell Host Microbe. 2024;32:2131–47.

    Article 
    PubMed 

    Google Scholar
     

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