Steel sulfide nanomaterials (MeSNs) are extremely promising for biomedical functions as a result of their low toxicity, good dispersibility, excessive stability, adjustable particle sizes, and good biocompatibility. Their distinctive chemical and light-conversion properties additionally allow them to operate as photothermal or photodynamic brokers, enhancing chemodynamic remedy (CDT) of tumors. This makes MeSNs worthwhile as photo-enhanced CDT nanoagents, advancing precision and multi-modal tumor therapy. This overview examines latest developments in MeSNs for photo-enhanced chemodynamic tumor ablation, evaluating their effectiveness in CDT. It highlights the roles of photothermal, photodynamic, and photocatalytic results in enhancing therapy efficacy. MeSN-based nanoreactors are categorized by composition into iron sulfide, copper sulfide, different unary, and multi-MeSNs for his or her functions in tumor remedy. Moreover, this overview discusses challenges, limitations, and future biomedical functions of MeSNs, providing insights into their potential for next-generation most cancers therapies.