These days, intracellular bacterial an infection brought on by antibiotic-resistant pathogens, reminiscent of methicillin-resistant Staphylococcus aureus (MRSA), poses an intractable menace to public well being. Intracellular MRSA is extraordinarily troublesome to eradicate by conventional antibiotics because of the poor intracellular accumulation and drug resistance. On this work, a novel multifunctional nanoantibiotic (GZNC) was constructed by MOF-derived nanozymes loaded with botanicals for synergistic therapy of intracellular antibiotic-resistant bacterial an infection. The nanoantibiotic built-in glycyrrhizinic acid (GA) into ZIF-8-derived nanozymes (ZNC), which achieved a managed launch of GA, glorious photothermal results and enhanced peroxidase-like (POD-like) exercise below the near-infrared (NIR) gentle irradiation. The nanoantibiotic confirmed the wonderful potential for in vivo and in vitro eradication of intracellular antibiotic-resistant micro organism. With the deserves of NIR light-actuated botanicals/photothermal remedy (PTT)/chemodynamic remedy (CDT), the nanoantibiotic may synergistically eradicate intracellular antibiotic-resistant micro organism and alleviate related an infection, offering a promising and biologically protected pathway to handle the intracellular antibiotic-resistant bacterial an infection.
