Investigating chiral light-matter interactions is crucial for advancing functions in sensing, imaging, and pharmaceutical improvement. Nevertheless, the chiroptical response in pure chiral molecules and subwavelength chiral constructions is inherently weak, with the characterization instrument restricted to optical strategies that make the most of the sunshine with spin angular momentum (SAM). To beat this, orbital angular momentum (OAM) beams, characterised by helical wavefronts, have emerged as a compelling analysis focus. Helical dichroism (HD) describes the differential absorbance of OAM beams with reverse indicators of topological prices. By utilizing inverse design with adjoint strategies for topology optimization, we design the chiral construction optimized to extend HD response below OAM beam incidence, demonstrating an enormous HD response of ~107% with topological prices |±l| = 3 on the wavelength of 800 nm. This research reveals distinct helicity-dependent interactions between the construction and OAM beams, highlighting the potential for custom-tuned chiroptical responses.
