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Monday, November 25, 2024

Viral capsid structural meeting governs the reovirus binding interface to NgR1


Nanoscale Horiz., 2024, Advance Article
DOI: 10.1039/D4NH00315B, Communication
Open Access Open Entry
Rita dos Santos Natividade, Andra C. Dumitru, Alessandro Nicoli, Michael Strebl, Danica M. Sutherland, Olivia L. Welsh, Mustafa Ghulam, Thilo Stehle, Terence S. Dermody, Antonella Di Pizio, Melanie Koehler, David Alsteens
We reveal how viral capsid protein group and curvature critically affect the soundness of reovirus–NgR1 interactions, with distinct variations noticed between single proteins, 2D assemblies, and 3D viral particles.
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