The usage of glucose oxidase (GOx) to disrupt glucose provide has been recognized as a promising technique in most cancers hunger remedy. Nonetheless, impartial supply of GOx is liable to degradation upon publicity to organic situations and will trigger injury to blood vessels and regular organs throughout transportation. Though some carriers can defend GOx from the encircling surroundings, the cruel preparation situations might compromise its exercise. Furthermore, the generally used supplies typically exhibit poor biocompatibility and possess sure cytotoxicity. To deal with this situation, we developed a delicate and environment friendly methodology primarily based on Pickering emulsion templates to synthesize protein-based microparticles utilizing zein because the matrix materials. These microparticles have excessive stability and will be tailor-made to effectively encapsulate biomolecules whereas preserving their exercise. Furthermore, the zein-based microparticles will be triggered to launch biomolecules in tumor cells underneath excessive glutathione ranges, demonstrating glorious responsiveness, biocompatibility, and low cytotoxicity. Moreover, when loaded with GOx, these protein-based microparticles successfully deprive tumor cells of vitamins and induce apoptosis by producing excessive ranges of H2O2, thereby exhibiting enhanced anticancer properties.
