The conduct of polyelectrolytes in confined areas has direct relevance to the protein mediated ion transport in residing organisms. On this paper, we govern lithium chloride transport by the interface supplied by polyelectrolytes, polycation, poly(diallyldimethylammonium chloride) (PDDA) and, polyanion, double stranded deoxyribonucleic acid (dsDNA), in confined graphene oxide (GO) membranes. Polyelectrolyte–GO interfaces display neuromorphic capabilities that have been efficiently utilized with nanochannel ion interactions contributed, leading to ion reminiscence results. Excitatory and inhibitory post-synaptic currents have been tuned constantly because the variety of pulses utilized elevated accordingly, growing decay occasions. Moreover, we demonstrated the short-term reminiscence of a educated vs untrained machine in computation. On account of its easy and protected manufacturing together with its robustness and stability, we anticipate our machine to be a low dimensional constructing block for arrays to embed synthetic neural networks in {hardware} for neuromorphic computing. Moreover, incorporating such gadgets with sensing and actuating components for a whole suggestions loop produces robotics with its personal capacity to study by modifying actuation primarily based on sensing knowledge.