Zhang D, Kukkar D, Kaur H, Kim KH. Latest advances within the synthesis and functions of single-atom nanozymes in meals security monitoring. Adv Colloid Interface Sci. 2023;319: 102968.
Li Y, Zhang Q, Pang X, Luo Y, Huang Ok, He X, et al. Fe-N-C nanozyme mediated bioactive paper-3D printing integration know-how permits moveable detection of lactose in milk. Sens Actuators, B Chem. 2022;368: 132111.
Navya PN, Mehla S, Begum A, Chaturvedi HK, Ojha R, Hartinger C, et al. Good nanozymes for most cancers remedy: the following frontier in oncology. Adv Healthc Mater. 2023;12: e2300768.
Manea F, Houillon FB, Pasquato L, Scrimin P. Nanozymes: gold-nanoparticle-based transphosphorylation catalysts. Angew Chem Int Ed. 2004;43:6165–9.
Gao L, Zhuang J, Nie L, Zhang J, Zhang Y, Gu N, et al. Intrinsic peroxidase-like exercise of ferromagnetic nanoparticles. Nat Nanotechnol. 2007;2:577–83.
Mo W, Liu S, Zhao X, Wei F, Li Y, Sheng X, et al. ROS scavenging nanozyme modulates immunosuppression for sensitized most cancers immunotherapy. Adv Healthc Mater. 2023;12: e2300191.
Zeng F, Shi Y, Wu C, Liang J, Zhong Q, Briley Ok, et al. A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel illness. J Nanobiotechnol. 2022;20:107.
Hu R, Dai C, Dong C, Ding L, Huang H, Chen Y, et al. Residing macrophage-delivered tetrapod PdH nanoenzyme for focused atherosclerosis administration by ROS scavenging, hydrogen anti-inflammation, and autophagy activation. ACS Nano. 2022;16:15959–76.
Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW. World tendencies in diabetes problems: a evaluate of present proof. Diabetologia. 2019;62:3–16.
Cole JB, Florez JC. Genetics of diabetes mellitus and diabetes problems. Nat Rev Nephrol. 2020;16:377–90.
Magliano DJ, Islam RM, Barr ELM, Gregg EW, Pavkov ME, Harding JL, et al. Tendencies in incidence of whole or kind 2 diabetes: systematic evaluate. BMJ. 2019;366: l5003.
Hotamisligil GS. Irritation and metabolic issues. Nature. 2006;444:860–7.
Valenzuela PL, Carrera-Bastos P, Castillo-García A, Lieberman DE, Santos-Lozano A, Lucia A. Weight problems and the chance of cardiometabolic illnesses. Nat Rev Cardiol. 2023;20:475–94.
Wu HZ, Ballantyne CM. Metabolic irritation and insulin resistance in weight problems. Circ Res. 2020;126:1549–64.
Rani V, Deep G, Singh RK, Palle Ok, Yadav UCS. Oxidative stress and metabolic issues: pathogenesis and therapeutic methods. Life Sci. 2016;148:183–93.
Bhatti JS, Bhatti GK, Reddy PH. Mitochondrial dysfunction and oxidative stress in metabolic issues—a step in direction of mitochondria primarily based therapeutic methods. Biochim Biophys Acta Mol Foundation Dis. 2017;1863:1066–77.
Singh R, Devi S, Gollen R. Function of free radical in atherosclerosis, diabetes and dyslipidaemia: larger-than-life. Diabetes Metab Res Rev. 2015;31:113–26.
Weight problems and obese. https://www.who.int/news-room/fact-sheets/element/obesity-and-overweight.
Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. World and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: outcomes from the Worldwide Diabetes Federation Diabetes Atlas, 9(th) version. Diabetes Res Clin Pract. 2019;157: 107843.
Milano J, McKay J, Dagenais C, Foster-Brown L, Pognan F, Gadient R, et al. Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes identified to specify intestine secretory lineage differentiation. Toxicol Sci. 2004;82:341–58.
Perdomo CM, Cohen RV, Sumithran P, Clément Ok, Frühbeck G. Modern medical, system, and surgical therapies for weight problems in adults. Lancet. 2023;401:1116–30.
Schauer PR, Bhatt DL, Kirwan JP, Wolski Ok, Aminian A, Brethauer SA, et al. Bariatric surgical procedure versus intensive medical remedy for diabetes—5-year outcomes. N Engl J Med. 2017;376:641–51.
Feng J, Wang X, Ye X, Ares I, Lopez-Torres B, Martínez M, et al. Mitochondria as an vital goal of metformin: the mechanism of motion, poisonous and uncomfortable side effects, and new therapeutic functions. Pharmacol Res. 2022;177: 106114.
DeFronzo R, Fleming GA, Chen Ok, Bicsak TA. Metformin-associated lactic acidosis: present views on causes and threat. Metabolism. 2016;65:20–9.
McCreight LJ, Stage TB, Connelly P, Lonergan M, Nielsen F, Prehn C, et al. Pharmacokinetics of metformin in sufferers with gastrointestinal intolerance. Diabetes Obes Metab. 2018;20:1593–601.
Tsou YH, Wang B, Ho W, Hu B, Tang P, Candy S, et al. Nanotechnology-mediated drug supply for the therapy of weight problems and its associated comorbidities. Adv Healthc Mater. 2019;8: e1801184.
Chen L, Xing S, Lei Y, Chen Q, Zou Z, Quan Ok, et al. A glucose-powered activatable nanozyme breaking pH and H2O2 limitations for treating diabetic infections. Angew Chem Int Ed Engl. 2021;60:23534–9.
Zhang Y, Liu W, Wang X, Liu Y, Wei H. Nanozyme-enabled therapy of cardio- and cerebrovascular illnesses. Small. 2023;19: e2204809.
Wan Q, Huang B, Li T, Xiao Y, He Y, Du W, et al. Selective concentrating on of visceral adiposity by polycation nanomedicine. Nat Nanotechnol. 2022;17:1311–21.
Guo HH, Feng CL, Zhang WX, Luo ZG, Zhang HJ, Zhang TT, et al. Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic illnesses. Nat Commun. 2019;10:1981.
Han YK, Jeong EJ, Search engine optimisation Y, Lee IY, Choi S, Lee H, et al. Adipocytolytic polymer nanoparticles for localized fats discount. ACS Nano. 2023;17:70–83.
Ye ZW, Zhang J, Townsend DM, Tew KD. Oxidative stress, redox regulation and illnesses of mobile differentiation. Biochim Biophys Acta. 2015;1850:1607–21.
Deprince A, Haas JT, Staels B. Dysregulated lipid metabolism hyperlinks NAFLD to heart problems. Mol Metab. 2020;42: 101092.
Wang S, Yang N, Zhang H. Metabolic dysregulation of lymphocytes in autoimmune illnesses. Tendencies Endocrinol Metabolism. 2024. https://doi.org/10.1016/j.tem.2024.1001.1005.
Otaki Y, Watanabe T, Kinoshita D, Yokoyama M, Takahashi T, Toshima T, et al. Affiliation of plasma xanthine oxidoreductase exercise with severity and medical consequence in sufferers with continual coronary heart failure. Int J Cardiol. 2017;228:151–7.
Pinkosky SL, Groot PHE, Lalwani ND, Steinberg GR. Focusing on ATP-citrate lyase in hyperlipidemia and metabolic issues. Tendencies Mol Med. 2017;23:1047–63.
Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, et al. Abrogation of hepatic ATP-citrate lyase protects towards fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Hepatology. 2009;49:1166–75.
Yang WP, Yang X, Zhu LJ, Chu HS, Li XY, Xu WT. Nanozymes: exercise origin, catalytic mechanism, and organic software. Coord Chem Rev. 2021;448: 214170.
Chen Z, Yu Y, Gao Y, Zhu Z. Rational design methods for nanozymes. ACS Nano. 2023;17:13062–80.
Meng F, Zhu P, Yang L, Xia L, Liu H. Nanozymes with atomically dispersed metallic facilities: construction–exercise relationships and biomedical functions. Chem Eng J. 2023;452: 139411.
Wu Y, Wu J, Jiao L, Xu W, Wang H, Wei X, et al. Cascade response system integrating single-atom nanozymes with ample Cu websites for enhanced biosensing. Anal Chem. 2020; 92(4):3373-3379
Zhang J, Wu TS, Thang HV, Tseng KY, Hao X, Xu B, et al. Cluster nanozymes with optimized reactivity and utilization of lively websites for efficient peroxidase (and oxidase) mimicking. Small. 2022;18: e2104844.
Qu Y, Wang L, Li Z, Li P, Zhang Q, Lin Y, et al. Ambient synthesis of single-atom catalysts from bulk metallic by way of trapping of atoms by floor dangling bonds. Adv Mater. 2019;31: e1904496.
Sha M, Xu W, Fang Q, Wu Y, Gu W, Zhu C, et al. Steel-organic-framework-involved nanobiocatalysis for biomedical functions. Chem Catalysis. 2022;2:2552–89.
Yuan S, Peng J, Cai B, Huang Z, Garcia-Esparza AT, Sokaras D, et al. Tunable metallic hydroxide-organic frameworks for catalysing oxygen evolution. Nat Mater. 2022;21:673–80.
Lu W, Guo Y, Zhang J, Yue Y, Fan L, Li F, et al. a excessive catalytic exercise nanozyme primarily based on cobalt-doped carbon dots for biosensor and anticancer cell impact. ACS Appl Mater Interfaces. 2022;14:57206–14.
Zhou C, Zhang L, Xu Z, Solar T, Gong M, Liu Y, et al. Self-propelled ultrasmall AuNPs-tannic acid hybrid nanozyme with ROS-scavenging and anti inflammatory exercise for drug-induced liver damage alleviation. Small. 2023;19: e2206408.
Zhang DY, Tu T, Younis MR, Zhu KS, Liu H, Lei S, et al. Clinically translatable gold nanozymes with broad spectrum antioxidant and anti inflammatory exercise for assuaging acute kidney damage. Theranostics. 2021;11:9904–17.
Dashtestani F, Ghourchian H, Najafi A. Silver-gold-apoferritin nanozyme for suppressing oxidative stress throughout cryopreservation. Mater Sci Eng C Mater Biol Appl. 2019;94:831–40.
Zhou X, You M, Wang F, Wang Z, Gao X, Jing C, et al. Multifunctional graphdiyne-cerium oxide nanozymes facilitate microRNA supply and attenuate tumor hypoxia for extremely environment friendly radiotherapy of esophageal most cancers. Adv Mater. 2021;33: e2100556.
Zhu W, Mei J, Zhang X, Zhou J, Xu D, Su Z, et al. Photothermal nanozyme-based microneedle patch towards refractory bacterial biofilm an infection by way of iron-actuated Janus ion remedy. Adv Mater. 2022;34: e2207961.
Ali A, Ovais M, Zhou H, Rui Y, Chen C. Tailoring metal-organic frameworks-based nanozymes for bacterial theranostics. Biomaterials. 2021;275: 120951.
Zhang X, Li G, Wu D, Li X, Hu N, Chen J, et al. Latest progress within the design fabrication of metal-organic frameworks-based nanozymes and their functions to sensing and most cancers remedy. Biosens Bioelectron. 2019;137:178–98.
Shang L, Yu Y, Jiang Y, Liu X, Sui N, Yang D, et al. Ultrasound-augmented multienzyme-like nanozyme hydrogel spray for selling diabetic wound therapeutic. ACS Nano. 2023;17:15962–77.
Hock N, Racaniello GF, Aspinall S, Denora N, Khutoryanskiy VV, Bernkop-Schnürch A. Thiolated nanoparticles for biomedical functions: mimicking the workhorses of our physique. Adv Sci (Weinh). 2022;9: e2102451.
Albrecht-Schgoer Ok, Barthelmes J, Schgoer W, Theurl M, Nardin I, Lener D, et al. Nanoparticular supply system for a secretoneurin spinoff induces angiogenesis in a hind limb ischemia mannequin. J Management Launch. 2017;250:1–8.
Arriortua OK, Insausti M, Lezama L, Gil de Muro I, Garaio E, de la Fuente JM, et al. RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia. Colloids Surf B Biointerfaces. 2018;165:315–24.
Neves AR, van der Putten L, Queiroz JF, Pinheiro M, Reis S. Transferrin-functionalized lipid nanoparticles for curcumin mind supply. J Biotechnol. 2021;331:108–17.
Yan L, Chen W, Zhu X, Huang L, Wang Z, Zhu G, et al. Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug supply. Chem Commun (Camb). 2013;49:10938–40.
Jin Y, Zhang J, Xu Y, Yi Ok, Li F, Zhou H, et al. Stem cell-derived hepatocyte remedy utilizing versatile biomimetic nanozyme included nanofiber-reinforced decellularized extracellular matrix hydrogels for the therapy of acute liver failure. Bioact Mater. 2023;28:112–31.
Richter LR, Wan Q, Wen D, Zhang Y, Yu J, Kang JK, et al. Focused supply of notch inhibitor attenuates obesity-induced glucose intolerance and liver fibrosis. ACS Nano. 2020;14:6878–86.
Achadu OJ, Abe F, Hossain F, Nasrin F, Yamazaki M, Suzuki T, et al. Sulfur-doped carbon dots@polydopamine-functionalized magnetic silver nanocubes for dual-modality detection of norovirus. Biosens Bioelectron. 2021;193: 113540.
Yang L, Guo H, Hou T, Zhang J, Li F. Steel-mediated Fe3O4@polydopamine-aptamer seize nanoprobe coupling multifunctional MXene@Au@Pt nanozyme for direct and moveable photothermal evaluation of circulating breast most cancers cells. Biosens Bioelectron. 2023;234: 115346.
Meng Y, Liu P, Zhou W, Ding J, Liu J. Bioorthogonal DNA adsorption on polydopamine nanoparticles mediated by metallic coordination for extremely strong sensing in serum and residing cells. ACS Nano. 2018;12:9070–80.
Zhang Y, Wen CP, Liu YJ, Li AQ, Guo QY, Zhang X, et al. NIR responsive composite nanomaterials with in-situ deposition of cascaded nanozymes for a number of synergistic remedy of bacterial an infection in diabetic mice. Chem Eng J. 2023;470:14.
Yan J, Wang Y, Mu Z, Han X, Bi L, Wang X, et al. Gold nanobipyramid-mediated apoptotic camouflage of adipocytes for weight problems immunotherapy. Adv Mater. 2023;35: e2207686.
Seijo B, Fattal E, Roblottreupel L, Couvreur P. Design of nanoparticles of lower than 50 nm diameter: preparation, characterization and drug load. Int J Pharm. 1990;62:1–7.
Bélteky P, Rónavári A, Zakupszky D, Boka E, Igaz N, Szerencsés B, et al. Are smaller nanoparticles at all times higher? Understanding the organic impact of size-dependent silver nanoparticle aggregation beneath biorelevant circumstances. Int J Nanomed. 2021;16:3021–40.
Shi L, Zhang J, Zhao M, Tang S, Cheng X, Zhang W, et al. Results of polyethylene glycol on the floor of nanoparticles for focused drug supply. Nanoscale. 2021;13:10748–64.
Niu Y, Zhu J, Li Y, Shi H, Gong Y, Li R, et al. Dimension shrinkable drug supply nanosystems and priming the tumor microenvironment for deep intratumoral penetration of nanoparticles. J Management Launch. 2018;277:35–47.
Xi Z, Gao W, Xia X. Dimension impact in Pd-Ir core-shell nanoparticles as nanozymes. ChemBioChem. 2020;21:2440–4.
Ren X, Chen D, Wang Y, Li H, Zhang Y, Chen H, et al. Nanozymes-recent improvement and biomedical functions. J Nanobiotechnol. 2022;20:92.
Wang Z, Zhang R, Yan X, Fan Ok. Construction and exercise of nanozymes: inspirations for de novo design of nanozymes. Mater Right now. 2020;41:81–119.
Fan H, Zheng J, Xie J, Liu J, Gao X, Yan X, et al. Floor ligand engineering ruthenium nanozyme superior to horseradish peroxidase for enhanced immunoassay. Adv Mater. 2023;36: e2300387.
Zhao Y, Track S, Wang D, Liu H, Zhang J, Li Z, et al. Nanozyme-reinforced hydrogel as a H2O2-driven oxygenerator for enhancing prosthetic interface osseointegration in rheumatoid arthritis remedy. Nat Commun. 2022;13:6758.
Thalhauser S, Breunig M. Issues for environment friendly floor functionalization of nanoparticles with a excessive molecular weight protein as concentrating on ligand. Eur J Pharm Sci. 2020;155: 105520.
Oh MJ, Yoon S, Babeer A, Liu Y, Ren Z, Xiang Z, et al. Nanozyme-based robotics method for concentrating on fungal an infection. Adv Mater. 2023;36: e2300320.
Zhang Z, Zhou D, Luan X, Wang X, Zhu Z, Luo W, et al. Biodegradable hole nanoscavengers restore liver capabilities to reverse insulin resistance in kind 2 diabetes. ACS Nano. 2023;17:9313–25.
Liu J, Shi X, Qu Y, Wang G. Functionalized ZnMnFe2O4-PEG-FA nanoenzymes integrating prognosis and remedy for concentrating on hepatic carcinoma guided by multi-modality imaging. Nanoscale. 2023;15:11013–25.
D’Souza AA, Devarajan PV. Asialoglycoprotein receptor mediated hepatocyte concentrating on—methods and functions. J Management Launch. 2015;203:126–39.
Nie H, Zheng P, Luo L-H, Cheng Y. Optimization of lipase-catalyzed synthesis of novel galactosyl ligands for selective concentrating on of liposomes to the asialoglycoprotein receptor. Biocatal Biotransform. 2015;33:130–9.
Fu X, Shi Y, Qi T, Qiu S, Huang Y, Zhao X, et al. Exact design methods of nanomedicine for bettering most cancers therapeutic efficacy utilizing subcellular concentrating on. Sign Transduct Goal Ther. 2020;5:262.
Ali A, Shah T, Ullah R, Zhou P, Guo M, Ovais M, et al. Overview on latest progress in magnetic nanoparticles: synthesis, characterization, and various functions. Entrance Chem. 2021;9: 629054.
Hou J, Xianyu Y. Tailoring the floor and composition of nanozymes for enhanced bacterial binding and antibacterial exercise. Small. 2023;19: e2302640.
Gained YW, Adhikary PP, Lim KS, Kim HJ, Kim JK, Kim YH. Oligopeptide complicated for focused non-viral gene supply to adipocytes. Nat Mater. 2014;13:1157–64.
Van Simaeys D, De La Fuente A, Zilio S, Zoso A, Kuznetsova V, Alcazar O, et al. RNA aptamers particular for transmembrane p24 trafficking protein 6 and Clusterin for the focused supply of imaging reagents and RNA therapeutics to human β cells. Nat Commun. 2022;13:1815.
Tian T, Zhang HX, He CP, Fan S, Zhu YL, Qi C, et al. Floor functionalized exosomes as focused drug supply automobiles for cerebral ischemia remedy. Biomaterials. 2018;150:137–49.
Huang X, Wu W, Jing D, Yang L, Guo H, Wang L, et al. Engineered exosome as focused lncRNA MEG3 supply automobiles for osteosarcoma remedy. J Management Launch. 2022;343:107–17.
Gajula SNR, Nathani TN, Patil RM, Talari S, Sonti R. Aldehyde oxidase mediated drug metabolism: an underpredicted impediment in drug discovery and improvement. Drug Metab Rev. 2022;54:427–48.
Reinke H, Asher G. Circadian clock management of liver metabolic capabilities. Gastroenterology. 2016;150:574–80.
Teng W, Zhao L, Yang S, Zhang C, Liu M, Luo J, et al. The hepatic-targeted, resveratrol loaded nanoparticles for reduction of excessive fats diet-induced nonalcoholic fatty liver illness. J Management Launch. 2019;307:139–49.
Tong Y, Yu X, Huang Y, Zhang Z, Mi L, Bao Z. Hepatic-targeted nano-enzyme with resveratrol loading for exact reduction of nonalcoholic steatohepatitis. ChemMedChem. 2023;18: e202200468.
Hossen MN, Kajimoto Ok, Akita H, Hyodo M, Ishitsuka T, Harashima H. Ligand-based focused supply of a peptide modified nanocarrier to endothelial cells in adipose tissue. J Management Launch. 2010;147:261–8.
Xue Y, Xu X, Zhang XQ, Farokhzad OC, Langer R. Stopping diet-induced weight problems in mice by adipose tissue transformation and angiogenesis utilizing focused nanoparticles. Proc Natl Acad Sci U S A. 2016;113:5552–7.
Zhuang M, Du D, Pu L, Track H, Deng M, Lengthy Q, et al. SPION-decorated exosome delivered BAY55-9837 concentrating on the pancreas via magnetism to enhance the blood GLC response. Small. 2019;15: e1903135.
Li S, Shang L, Xu B, Wang S, Gu Ok, Wu Q, et al. A nanozyme with photo-enhanced twin enzyme-like actions for deep pancreatic most cancers remedy. Angew Chem Int Ed Engl. 2019;58:12624–31.
Lankelma J, Nie Z, Carrilho E, Whitesides GM. Paper-based analytical system for electrochemical flow-injection evaluation of glucose in urine. Anal Chem. 2012;84:4147–52.
Tierney S, Falch BM, Hjelme DR, Stokke BT. Willpower of glucose ranges utilizing a functionalized hydrogel-optical fiber biosensor: towards steady monitoring of blood glucose in vivo. Anal Chem. 2009;81:3630–6.
Sackmann EK, Fulton AL, Beebe DJ. The current and future position of microfluidics in biomedical analysis. Nature. 2014;507:181–9.
Cheng H, Zhang L, He J, Guo W, Zhou Z, Zhang X, et al. Built-in nanozymes with nanoscale proximity for in vivo neurochemical monitoring in residing brains. Anal Chem. 2016;88:5489–97.
Wang Q, Zhang X, Huang L, Zhang Z, Dong S. GOx@ZIF-8(NiPd) nanoflower: a synthetic enzyme system for tandem catalysis. Angew Chem Int Ed Engl. 2017;56:16082–5.
Piao Y, Han DJ, Azad MR, Park M, Search engine optimisation TS. Enzyme included microfluidic system for in-situ glucose detection in water-in-air microdroplets. Biosens Bioelectron. 2015;65:220–5.
Nguyen QH, Lee DH, Nguyen PT, Le PG, Kim MI. Foldable paper microfluidic system primarily based on single iron site-containing hydrogel nanozyme for environment friendly glucose biosensing. Chem Eng J. 2023. https://doi.org/10.1016/j.cej.2022.140541.
Zhou Y, Liu C, Yu Y, Yin M, Solar J, Huang J, et al. An organelle-specific nanozyme for diabetes care in genetically or diet-induced fashions. Adv Mater. 2020;32: e2003708.
Track G, Xu J, Zhong H, Zhang Q, Wang X, Lin Y, et al. Single-atom Ce-N4-C-(OH)2 nanozyme-catalyzed cascade response to alleviate hyperglycemia. Analysis (Wash D C). 2023;6:0095.
Chang M, Hou Z, Wang M, Wen D, Li C, Liu Y, et al. Cu single atom nanozyme primarily based high-efficiency delicate photothermal remedy via mobile metabolic regulation. Angew Chem Int Ed Engl. 2022;61: e202209245.
Zhang H, Ma J, Tang Ok, Huang B. Past power storage: roles of glycogen metabolism in well being and illness. FEBS J. 2021;288:3772–83.
Keinan O, Valentine JM, Xiao H, Mahata SK, Reilly SM, Abu-Odeh M, et al. Glycogen metabolism hyperlinks glucose homeostasis to thermogenesis in adipocytes. Nature. 2021;599:296–301.
Yang Q, Vijayakumar A, Kahn BB. Metabolites as regulators of insulin sensitivity and metabolism. Nat Rev Mol Cell Biol. 2018;19:654–72.
Park SE, Park CY, Sweeney G. Biomarkers of insulin sensitivity and insulin resistance: previous, current and future. Crit Rev Clin Lab Sci. 2015;52:180–90.
Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, et al. Continual irritation within the etiology of illness throughout the life span. Nat Med. 2019;25:1822–32.
Parra-Robert M, Zeng M, Shu Y, Fernández-Varo G, Perramón M, Desai D, et al. Mesoporous silica coated CeO2 nanozymes with mixed lipid-lowering and antioxidant exercise induce long-term enchancment of the metabolic profile in overweight Zucker rats. Nanoscale. 2021;13:8452–66.
Li Z, Zhao Y, Huang H, Zhang C, Liu H, Wang Z, et al. A nanozyme-immobilized hydrogel with endogenous ROS-scavenging and oxygen technology talents for considerably selling oxidative diabetic wound therapeutic. Adv Healthc Mater. 2022;11: e2201524.
Zhou Z, Mei X, Hu Ok, Ma M, Zhang Y. Nanohybrid double community hydrogels primarily based on a platinum nanozyme composite for antimicrobial and diabetic wound therapeutic. ACS Appl Mater Interfaces. 2023;15:17612–26.
Zhang Y, Yin Y, Zhang W, Li H, Wang T, Yin H, et al. Reactive oxygen species scavenging and irritation mitigation enabled by biomimetic prussian blue analogues boycott atherosclerosis. J Nanobiotechnol. 2021;19:161.
Ding J, Du Y, Hu X, Zhao M, Li Y, Li L, et al. Aptamer-modified atomically exact gold nanoclusters as focused nanozymes to scavenge reactive oxygen species in white adipocytes. Nanotechnology. 2023;34: 365101.
Wang S, Zhou Y, Liang X, Xu M, Li N, Zhao Ok. Platinum-cerium bimetallic nano-raspberry for atherosclerosis therapy by way of synergistic foam cell inhibition and P2Y12 focused antiplatelet aggregation. Chem Eng J. 2022;430: 132859.
Tu C, Lu H, Zhou T, Zhang W, Deng L, Cao W, et al. Selling the therapeutic of contaminated diabetic wound by an anti-bacterial and nano-enzyme-containing hydrogel with inflammation-suppressing, ROS-scavenging, oxygen and nitric oxide-generating properties. Biomaterials. 2022;286: 121597.
Li Y, Fu R, Duan Z, Zhu C, Fan D. Injectable hydrogel primarily based on defect-rich multi-nanozymes for diabetic wound therapeutic by way of an oxygen self-supplying cascade response. Small. 2022;18: e2200165.
Du X, Jia B, Wang W, Zhang C, Liu X, Qu Y, et al. pH-switchable nanozyme cascade catalysis: a technique for spatial-temporal modulation of pathological wound microenvironment to rescue stalled therapeutic in diabetic ulcer. J Nanobiotechnol. 2022;20:12.
Piché ME, Tchernof A, Després JP. Weight problems phenotypes, diabetes, and cardiovascular illnesses. Circ Res. 2020;126:1477–500.
Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Elevated oxidative stress in weight problems and its influence on metabolic syndrome. J Clin Make investments. 2004;114:1752–61.
He F, Huang Y, Track Z, Zhou HJ, Zhang H, Perry RJ, et al. Mitophagy-mediated adipose irritation contributes to kind 2 diabetes with hepatic insulin resistance. J Exp Med. 2021;218: e20201416.
Zhang R, Xue B, Tao Y, Zhao H, Zhang Z, Wang X, et al. Edge-site engineering of faulty Fe-N4 nanozymes with boosted catalase-like efficiency for retinal vasculopathies. Adv Mater. 2022;34: e2205324.
Liu C, Fan W, Cheng W-X, Gu Y, Chen Y, Zhou W, et al. Purple emissive carbon dot superoxide dismutase nanozyme for bioimaging and ameliorating acute lung damage. Adv Funct Mater. 2023;33:2213856.
Gao W, He J, Chen L, Meng X, Ma Y, Cheng L, et al. Deciphering the catalytic mechanism of superoxide dismutase exercise of carbon dot nanozyme. Nat Commun. 2023;14:160.
Xu H, Ding J, Du Y, Li L, Li Y, Zhao M, et al. Aptamer-functionalized AuNCs nanogel for focused supply of docosahexaenoic acid to induce browning of white adipocytes. J Mater Chem B. 2023;11:4972–9.
WHO. Diabetes. 2021. https://www.who.int/health-topics/diabetes#tab=tab_1.
Nassif M, Kosiborod M. Impact of glucose-lowering therapies on coronary heart failure. Nat Rev Cardiol. 2018;15:282–91.
Jeon HJ, Kim HS, Chung E, Lee DY. Nanozyme-based colorimetric biosensor with a systemic quantification algorithm for noninvasive glucose monitoring. Theranostics. 2022;12:6308–38.
Libby P. The altering panorama of atherosclerosis. Nature. 2021;592:524–33.
Tektonidou MG. Heart problems threat in antiphospholipid syndrome: thrombo-inflammation and atherothrombosis. J Autoimmun. 2022;128: 102813.
Holl J, Kowalewski C, Zimek Z, Fiedor P, Kaminski A, Oldak T, et al. Continual diabetic wounds and their therapy with pores and skin substitutes. Cells. 2021;10:655.
Powers JG, Higham C, Broussard Ok, Phillips TJ. Wound therapeutic and treating wounds: continual wound care and administration. J Am Acad Dermatol. 2016;74:607–25; quiz 625–606.
Meng F, Peng M, Chen Y, Cai X, Huang F, Yang L, et al. Defect-rich graphene stabilized atomically dispersed Cu3 clusters with enhanced oxidase-like exercise for antibacterial functions. Appl Catal B. 2022;301: 120826.
Yang J, Zeng W, Xu P, Fu X, Yu X, Chen L, et al. Glucose-responsive multifunctional metal-organic drug-loaded hydrogel for diabetic wound therapeutic. Acta Biomater. 2022;140:206–18.
Kitabchi AE, Umpierrez GE, Murphy MB, Barrett EJ, Kreisberg RA, Malone JI, et al. Administration of hyperglycemic crises in sufferers with diabetes. Diabetes Care. 2001;24:131–53.
Catrina SB, Zheng X. Disturbed hypoxic responses as a pathogenic mechanism of diabetic foot ulcers. Diabetes Metab Res Rev. 2016;32(Suppl 1):179–85.
Shiekh PA, Singh A, Kumar A. Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound therapeutic. Biomaterials. 2020;249: 120020.
Wan L, Bai X, Zhou Q, Chen C, Wang H, Liu T, et al. The superior glycation end-products (AGEs)/ROS/NLRP3 inflammasome axis contributes to delayed diabetic corneal wound therapeutic and nerve regeneration. Int J Biol Sci. 2022;18:809–25.
Guan Y, Niu H, Liu Z, Dang Y, Shen J, Zayed M, et al. Sustained oxygenation accelerates diabetic wound therapeutic by selling epithelialization and angiogenesis and reducing irritation. Sci Adv. 2021;7:eabj0153.
Jiang J, Li X, Li H, Lv X, Xu Y, Hu Y, et al. Latest progress in nanozymes for the therapy of diabetic wounds. J Mater Chem B. 2023;11:6746–61.
Zhuang ZM, Wang Y, Feng ZX, Lin XY, Wang ZC, Zhong XC, et al. Focusing on various wounds and scars: latest modern bio-design of microneedle patch for complete administration. Small. 2023;12:e2306565.
Solar C, Zhou X, Liu C, Deng S, Track Y, Yang J, et al. An built-in therapeutic and preventive nanozyme-based microneedle for biofilm-infected diabetic wound therapeutic. Adv Healthc Mater. 2023;12:e2301474.
Li W, Bei Y, Pan X, Zhu J, Zhang Z, Zhang T, et al. Selenide-linked polydopamine-reinforced hybrid hydrogels with on-demand degradation and light-triggered nanozyme launch for diabetic wound therapeutic. Biomater Res. 2023;27:49.
Yu X, Fu X, Yang J, Chen L, Leng F, Yang Z, et al. Glucose/ROS cascade-responsive ceria nanozymes for diabetic wound therapeutic. Mater Right now Bio. 2022;15: 100308.
Obrosova IG, Chung SS, Kador PF. Diabetic cataracts: mechanisms and administration. Diabetes Metab Res Rev. 2010;26:172–80.
Zhou Y, Li L, Li S, Li S, Zhao M, Zhou Q, et al. Autoregenerative redox nanoparticles as an antioxidant and glycation inhibitor for palliation of diabetic cataracts. Nanoscale. 2019;11:13126–38.
Yang J, Gong X, Fang L, Fan Q, Cai L, Qiu X, et al. Potential of CeCl3@mSiO2 nanoparticles in assuaging diabetic cataract improvement and development. Nanomedicine. 2017;13:1147–55.
Zhang J, Liu J. Mild-activated nanozymes: catalytic mechanisms and functions. Nanoscale. 2020;12:2914–23.
Liang L, Jiang Y, Liu F, Li S, Wu J, Zhao S, et al. Three-in-one covalent natural framework nanozyme: self-reporting, self-correcting and light-responsive for fluorescence sensing 3-nitrotyrosine. Biosens Bioelectron. 2023;237: 115542.
Dai W, Shu R, Yang F, Li B, Johnson HM, Yu S, et al. Engineered bio-heterojunction confers extra- and intracellular bacterial ferroptosis and hunger-triggered cell safety for diabetic wound restore. Adv Mater. 2023;36:e2305277.
Yang Z, Chen X. Semiconducting perylene diimide nanostructure: multifunctional phototheranostic nanoplatform. Acc Chem Res. 2019;52:1245–54.
Xiao YF, An FF, Chen JX, Yu J, Tao WW, Yu Z, et al. The nanoassembly of an intrinsically cytotoxic near-infrared dye for multifunctionally synergistic theranostics. Small. 2019;15: e1903121.
Neri S, Garcia Martin S, Pezzato C, Prins LJ. Photoswitchable catalysis by a nanozyme mediated by a light-sensitive cofactor. J Am Chem Soc. 2017;139:1794–7.
Shan J, Yang Ok, Xiu W, Qiu Q, Dai S, Yuwen L, et al. Cu2MoS4 nanozyme with NIR-II mild enhanced catalytic exercise for environment friendly eradication of multidrug-resistant micro organism. Small. 2020;16: e2001099.
Li L, Yang J, Wei J, Jiang C, Liu Z, Yang B, et al. SERS monitoring of photoinduced-enhanced oxidative stress amplifier on Au@carbon dots for tumor catalytic remedy. Mild Sci Appl. 2022;11:286.
Zhu Y, Wang Z, Zhao R, Zhou Y, Feng L, Gai S, et al. Pt embellished Ti3C2Tx MXene with NIR-II mild amplified nanozyme catalytic exercise for environment friendly phototheranostics. ACS Nano. 2022;16:3105–18.
Liao ZY, Gao WW, Shao NN, Zuo JM, Wang T, Xu MZ, et al. Iron phosphate nanozyme-hydrogel with multienzyme-like exercise for environment friendly bacterial sterilization. ACS Appl Mater Interfaces. 2022;14:18170–81.
Tian Z, Li J, Zhang Z, Gao W, Zhou X, Qu Y. Extremely delicate and strong peroxidase-like exercise of porous nanorods of ceria and their software for breast most cancers detection. Biomaterials. 2015;59:116–24.
Dong C, Dai X, Wang X, Lu Q, Chen L, Track X, et al. A calcium fluoride nanozyme for ultrasound-amplified and Ca2+-overload-enhanced catalytic tumor nanotherapy. Adv Mater. 2022;34: e2205680.
Chang M, Wang Z, Dong C, Zhou R, Chen L, Huang H, et al. Ultrasound-amplified enzyodynamic tumor remedy by perovskite nanoenzyme-enabled cell pyroptosis and cascade catalysis. Adv Mater. 2023;35: e2208817.
Jana D, Wang D, Bindra AK, Guo Y, Liu J, Zhao Y. Ultrasmall alloy nanozyme for ultrasound- and near-infrared light-promoted tumor ablation. ACS Nano. 2021;15:7774–82.
Chowdhury SM, Abou-Elkacem L, Lee T, Dahl J, Lutz AM. Ultrasound and microbubble mediated therapeutic supply: underlying mechanisms and future outlook. J Management Launch. 2020;326:75–90.
Yang G, Zhou Y, Pan HB, Zhu C, Fu S, Wai CM, et al. Ultrasonic-assisted synthesis of Pd-Pt/carbon nanotubes nanocomposites for enhanced electro-oxidation of ethanol and methanol in alkaline medium. Ultrason Sonochem. 2016;28:192–8.
Costa JM, Almeida Neto AF. Ultrasound-assisted electrodeposition and synthesis of alloys and composite supplies: a evaluate. Ultrason Sonochem. 2020;68: 105193.
Solar D, Pang X, Cheng Y, Ming J, Xiang S, Zhang C, et al. Ultrasound-switchable nanozyme augments sonodynamic remedy towards multidrug-resistant bacterial an infection. ACS Nano. 2020;14:2063–76.
Chen X, Liao J, Lin Y, Zhang J, Zheng C. Nanozyme’s catalytic exercise at impartial pH: response substrates and software in sensing. Anal Bioanal Chem. 2023;415:3817–30.
Asati A, Kaittanis C, Santra S, Perez JM. pH-tunable oxidase-like exercise of cerium oxide nanoparticles reaching delicate fluorigenic detection of most cancers biomarkers at impartial pH. Anal Chem. 2011;83:2547–53.
Nguyen PT, Lee J, Cho A, Kim MS, Choi D, Han JW, et al. Rational improvement of co-doped mesoporous ceria with excessive peroxidase-mimicking exercise at impartial pH for paper-based colorimetric detection of a number of biomarkers. Adv Funct Mater. 2022;32:2112428.
Chen T, Zhao Q, Meng X, Li Y, Peng H, Whittaker AK, et al. Ultrasensitive magnetic tuning of optical properties of movies of cholesteric cellulose nanocrystals. ACS Nano. 2020;14:9440–8.
Majumder S, Dey S, Bagani Ok, Dey SK, Banerjee S, Kumar S. A comparative research on the structural, optical and magnetic properties of Fe3O4 and Fe3O4@SiO2 core-shell microspheres together with an evaluation of their potentiality as electrochemical double layer capacitors. Dalton Trans. 2015;44:7190–202.
He Y, Chen X, Zhang Y, Wang Y, Cui M, Li G, et al. Magnetoresponsive nanozyme: magnetic stimulation on the nanozyme exercise of iron oxide nanoparticles. Sci China Life Sci. 2022;65:184–92.
Wang Z, Zhao Y, Hou Y, Tang G, Zhang R, Yang Y, et al. A thrombin-activated peptide-templated nanozyme for remedying ischemic stroke by way of thrombolytic and neuroprotective actions. Adv Mater. 2023;36: e2210144.
Cheng C, Qiao J, Zhang H, Zhao Z, Qi L. Temperature modulating the peroxidase-mimic exercise of poly(N-isopropyl acrylamide) protected gold nanoparticles for colorimetric detection of glutathione. Spectrochim Acta A Mol Biomol Spectrosc. 2022;280: 121516.
Ji H, Zhang C, Xu F, Mao Q, Xia R, Chen M, et al. Inhaled pro-efferocytic nanozymes promote decision of acute lung damage. Adv Sci (Weinh). 2022;9: e2201696.
Zeng M, Zhang X, Tang J, Liu X, Lin Y, Guo D, et al. Conservation of the enzyme-like exercise and biocompatibility of CeO2 nanozymes in simulated physique fluids. Nanoscale. 2023;15:14365–79.
Ma X, Hao J, Wu J, Li Y, Cai X, Zheng Y. Prussian blue nanozyme as a pyroptosis inhibitor alleviates neurodegeneration. Adv Mater. 2022;34: e2106723.
Sahu A, Jeon J, Lee MS, Yang HS, Tae G. Antioxidant and anti inflammatory actions of Prussian blue nanozyme promotes full-thickness pores and skin wound therapeutic. Mater Sci Eng C Mater Biol Appl. 2021;119: 111596.
Abdelkhaliq A, van der Zande M, Punt A, Helsdingen R, Boeren S, Vervoort JJM, et al. Influence of nanoparticle floor functionalization on the protein corona and mobile adhesion, uptake and transport. J Nanobiotechnol. 2018;16:70.
Sanità G, Carrese B, Lamberti A. Nanoparticle floor functionalization: tips on how to enhance biocompatibility and mobile internalization. Entrance Mol Biosci. 2020;7: 587012.
Wei YJ, Li J, Hu ZE, Xing X, Zhou ZW, Yu Y, et al. A porphyrin-MOF-based built-in nanozyme system for catalytic cascades and light-enhanced synergistic amplification of mobile oxidative stress. J Mater Chem B. 2023;11:6581–94.
Haney MJ, Suresh P, Zhao Y, Kanmogne GD, Kadiu I, Sokolsky-Papkov M, et al. Blood-borne macrophage-neural cell interactions hitchhike on endosome networks for cell-based nanozyme mind supply. Nanomedicine (Lond). 2012;7:815–33.
Track Y, Wu Y, Xu L, Jiang T, Tang C, Yin C. Caveolae-mediated endocytosis drives strong siRNA supply of polymeric nanoparticles to macrophages. ACS Nano. 2021;15:8267–82.
Means N, Elechalawar CK, Chen WR, Bhattacharya R, Mukherjee P. Revealing macropinocytosis utilizing nanoparticles. Mol Points Med. 2022;83: 100993.
Zhang A, Meng Ok, Liu Y, Pan Y, Qu W, Chen D, et al. Absorption, distribution, metabolism, and excretion of nanocarriers in vivo and their influences. Adv Colloid Interface Sci. 2020;284: 102261.
Wani TU, Raza SN, Khan NA. Nanoparticle opsonization: forces concerned and safety by lengthy chain polymers. Polym Bull. 2020;77:3865–89.
Rasmussen MK, Pedersen JN, Marie R. Dimension and floor cost characterization of nanoparticles with a salt gradient. Nat Commun. 2020;11:2337.
Pustulka SM, Ling Ok, Pish SL, Champion JA. Protein nanoparticle cost and hydrophobicity govern protein corona and macrophage uptake. ACS Appl Mater Interfaces. 2020;12:48284–95.
Yu M, Xu J, Zheng J. Renal clearable luminescent gold nanoparticles: from the bench to the clinic. Angew Chem Int Ed Engl. 2019;58:4112–28.
Longmire M, Choyke PL, Kobayashi H. Clearance properties of nano-sized particles and molecules as imaging brokers: concerns and caveats. Nanomedicine (Lond). 2008;3:703–17.
Gao L, Fan Ok, Yan X. Iron oxide nanozyme: a multifunctional enzyme mimetic for biomedical functions. Theranostics. 2017;7:3207–27.
Cypriyana PJJ, SS, Angalene JLA, Samrot AV, Kumar SS, Ponniah P, et al. Overview on toxicity of nanoparticles, it is mechanism, fashions utilized in toxicity research and disposal strategies—a evaluate. Biocatal Agric Biotechnol. 2021; 36:102117.
Zhang S, Gao H, Bao G. Bodily rules of nanoparticle mobile endocytosis. ACS Nano. 2015;9:8655–71.
Zare EN, Zheng X, Makvandi P, Gheybi H, Sartorius R, Yiu CKY, et al. Nonspherical metal-based nanoarchitectures: synthesis and influence of dimension, form, and composition on their organic exercise. Small. 2021;17: e2007073.
Roshanzadeh A, Park S, Ganjbakhsh SE, Park J, Lee DH, Lee S, et al. Floor charge-dependent cytotoxicity of plastic nanoparticles in alveolar cells beneath cyclic stretches. Nano Lett. 2020;20:7168–76.
Shahbazi MA, Hamidi M, Mäkilä EM, Zhang H, Almeida PV, Kaasalainen M, et al. The mechanisms of floor chemistry results of mesoporous silicon nanoparticles on immunotoxicity and biocompatibility. Biomaterials. 2013;34:7776–89.
Murphy DA, Cheng H, Yang T, Yan X, Adjei IM. Reversing hypoxia with PLGA-encapsulated manganese dioxide nanoparticles improves pure killer cell response to tumor spheroids. Mol Pharm. 2021;18:2935–46.
Ho LWC, Yung WY, Sy KHS, Li HY, Choi CKK, Leung KC, et al. Impact of alkylation on the mobile uptake of polyethylene glycol-coated gold nanoparticles. ACS Nano. 2017;11:6085–101.
Braakhuis HM, Giannakou C, Peijnenburg WJ, Vermeulen J, van Loveren H, Park MV. Easy in vitro fashions can predict pulmonary toxicity of silver nanoparticles. Nanotoxicology. 2016;10:770–9.
Cao Y, Li S, Chen J. Modeling higher in vitro fashions for the prediction of nanoparticle toxicity: a evaluate. Toxicol Mech Strategies. 2021;31:1–17.
Chakraborty C, Sharma AR, Sharma G, Lee SS. Zebrafish: a whole animal mannequin to enumerate the nanoparticle toxicity. J Nanobiotechnol. 2016;14:65.
Attarilar S, Yang J, Ebrahimi M, Wang Q, Liu J, Tang Y, et al. The toxicity phenomenon and the associated incidence in metallic and metallic oxide nanoparticles: a quick evaluate from the biomedical perspective. Entrance Bioeng Biotechnol. 2020;8:822.
Huang M, Zhu Y, Xin G, Wang Y, Li F, Li S, et al. Multi-enzyme mimetic iridium nanozymes-based thrombus microenvironment-modulated nanoplatform for enhanced thrombolytic remedy. Chem Eng J. 2023;470: 144156.
Zhao X, Abulikemu A, Lv S, Qi Y, Duan J, Zhang J, et al. Oxidative stress- and mitochondrial dysfunction-mediated cytotoxicity by silica nanoparticle in lung epithelial cells from metabolomic perspective. Chemosphere. 2021;275: 129969.
Chrishtop VV, Prilepskii AY, Nikonorova VG, Mironov VA. Nanosafety vs nanotoxicology: sufficient animal fashions for testing in vivo toxicity of nanoparticles. Toxicology. 2021;462: 152952.
Armstrong DG, Tan TW, Boulton AJM, Bus SA. Diabetic foot ulcers: a evaluate. JAMA. 2023;330:62–75.
Sehit E, Altintas Z. Significance of nanomaterials in electrochemical glucose sensors: an up to date evaluate (2016–2020). Biosens Bioelectron. 2020;159: 112165.
Feng L, Dou C, Xia Y, Li B, Zhao M, Yu P, et al. Neutrophil-like cell-membrane-coated nanozyme remedy for ischemic mind injury and long-term neurological useful restoration. ACS Nano. 2021;15:2263–80.
Xue B, Ge M, Fan Ok, Huang X, Yan X, Jiang W, et al. Mitochondria-targeted nanozymes get rid of oxidative injury in retinal neovascularization illness. J Management Launch. 2022;350:271–83.
Subin TS, Vijayan V, Kumar KJR. Up to date regulatory concerns for nanomedicines. Pharm Nanotechnol. 2017;5:180–91.
Bleeker EAJ, Swart E, Braakhuis H, Fernández Cruz ML, Friedrichs S, Gosens I, et al. In direction of harmonisation of testing of nanomaterials for EU regulatory necessities on chemical security—a proposal for additional actions. Regul Toxicol Pharmacol. 2023;139: 105360.
Sheng J, Wu Y, Ding H, Feng Ok, Shen Y, Zhang Y, et al. Multienzyme-like nanozymes: regulation, rational design, and software. Adv Mater. 2023;36: e2211210.