Kwon T, Lamster IB, Levin L. Present ideas within the administration of periodontitis. Int Dent J. 2021;71:462–76.
Slots J. Periodontitis: info, fallacies and the longer term. Periodontol 2000. 2017;75:7–23.
Trindade D, Carvalho R, Machado V, Chambrone L, Mendes JJ, Botelho J. Prevalence of periodontitis in dentate folks between 2011 and 2020: a scientific evaluate and meta-analysis of epidemiological research. J Clin Periodontol. 2023;50:604–26.
Mainas G, Ide M, Rizzo M, Magan-Fernandez A, Mesa F, Nibali L. Managing the systemic impression of periodontitis. Med (Mex). 2022;58:621.
Graziani F, Karapetsa D, Alonso B, Herrera D. Nonsurgical and surgical therapy of periodontitis: what number of choices for one illness? Periodontol 2000. 2017;75:152–88.
HAAS AN, FURLANETO F, GAIO EJ, GOMES SC, PALIOTO DB, CASTILHO RM, et al. New tendencies in non-surgical periodontal remedy. Braz Oral Res. 2021;35:e095.
Cobb CM. Lasers and the therapy of periodontitis: the essence and the noise. Periodontol. 2000. 2017;75:205–95.
Welsh JA, Goberdhan DCI, O’Driscoll L, Buzas EI, Blenkiron C, Bussolati B, et al. Minimal info for research of extracellular vesicles (MISEV2023): from primary to superior approaches. J Extracell Vesicles. 2024;13:e12404.
Halperin W, Jensen WA. Ultrastructural adjustments throughout development and embryogenesis in carrot cell cultures. J Ultrastruct Res. 1967;18:428–43.
Zhao B, Lin H, Jiang X, Li W, Gao Y, Li M, et al. Exosome-like nanoparticles derived from fruits, greens, and herbs: revolutionary methods of therapeutic and drug supply. Theranostics. 2024;14:4598–621.
Kim J, Zhu Y, Chen S, Wang D, Zhang S, Xia J, et al. Anti-glioma impact of ginseng-derived exosomes-like nanoparticles by lively blood–brain-barrier penetration and tumor microenvironment modulation. J Nanobiotechnol. 2023;21:253.
Subudhi PD, Bihari C, Sarin SK, Baweja S. Rising function of edible Exosomes-Like nanoparticles (ELNs) as hepatoprotective brokers. Nanotheranostics. 2022;6:365–75.
Dad HA, Gu T-W, Zhu A-Q, Huang L-Q, Peng L-H. Plant exosome-like nanovesicles: rising therapeutics and drug supply nanoplatforms. Mol Ther. 2021;29:13–31.
Sundaram Okay, Miller DP, Kumar A, Teng Y, Sayed M, Mu J, et al. Plant-derived exosomal nanoparticles inhibit pathogenicity of Porphyromonas gingivalis. iScience. 2019;21:308–27.
Wang X, Tian R, Liang C, Jia Y, Zhao L, Xie Q, et al. Biomimetic nanoplatform with microbiome modulation and antioxidant features ameliorating insulin resistance and pancreatic β-cell dysfunction for T2DM administration. Biomaterials. 2025;313:122804.
Sundaram Okay, Mu J, Kumar A, Behera J, Lei C, Sriwastva MK, et al. Garlic exosome-like nanoparticles reverse high-fat eating regimen induced weight problems by way of the intestine/mind axis. Theranostics. 2022;12:1220–46.
Cao M, Diao N, Cai X, Chen X, Xiao Y, Guo C, et al. Plant exosome nanovesicles (PENs): inexperienced supply platforms. Mater Horiz. 2023;10:3879–94.
Li D, Tang Q, Yang M, Xu H, Zhu M, Zhang Y, et al. Plant-derived exosomal nanoparticles: potential therapeutic for inflammatory bowel illness. Nanoscale Adv. 2023;5:3575–88.
Tan X, Xu Y, Zhou S, Pan M, Cao Y, Cai X, et al. Advances within the research of Plant-Derived Vesicle-Like nanoparticles in inflammatory illnesses. J Inflamm Res. 2023;16:4363–72.
Chen X, Ji S, Yan Y, Lin S, He L, Huang X, et al. Engineered Plant-Derived nanovesicles facilitate tumor remedy: pure bioactivity plus drug managed launch platform. Int J Nanomed. 2023;18:4779–804.
Zhang Q, Jeppesen DK, Higginbotham JN, Franklin JL, Coffey RJ. Complete isolation of extracellular vesicles and nanoparticles. Nat Protoc. 2023;18:1462–87.
Bokka R, Ramos AP, Fiume I, Manno M, Raccosta S, Turiák L, et al. Biomanufacturing of tomato-derived nanovesicles. Meals. 2020;9: 1852.
Pinedo M, de la Canal L, de Marcos Lousa C. A name for rigor and standardization in plant extracellular vesicle analysis. J Extracell Vesicles. 2021;10:e12048.
Rutter BD, Innes RW. Extracellular vesicles remoted from the leaf Apoplast carry Stress-Response proteins. Plant Physiol. 2017;173:728–41.
Cao M, Yan H, Han X, Weng L, Wei Q, Solar X, et al. Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma development. J ImmunoTher Most cancers. 2019;7:326.
Zhuang W-R, Wang Y, Lei Y, Zuo L, Jiang A, Wu G, et al. Phytochemical engineered bacterial outer membrane vesicles for photodynamic results promoted immunotherapy. Nano Lett. 2022;22:4491–500.
Cui Y, Shen J, Gao C, Zhuang X, Wang J, Jiang L. Biogenesis of plant prevacuolar multivesicular our bodies. Mol Plant. 2016;9:774–86.
Farley JT, Eldahshoury MK, de Marcos Lousa C. Unconventional secretion of plant extracellular vesicles and their advantages to human well being: A mini evaluate. Entrance Cell Dev Biol. 2022;10:883841.
Alfieri M, Leone A, Ambrosone A. Plant-derived nano and microvesicles for human well being and therapeutic potential in nanomedicine. Pharmaceutics. 2021;13(4): 13:498.
Yugay Y, Tsydeneshieva Z, Rusapetova T, Grischenko O, Mironova A, Bulgakov D, et al. Isolation and characterization of extracellular vesicles from Arabidopsis Thaliana cell tradition and investigation of the specificities of their biogenesis. Vegetation. 2023;12:3604.
Wang J, Ding Y, Wang J, Hillmer S, Miao Y, Lo SW, et al. EXPO, an Exocyst-Optimistic organelle distinct from multivesicular endosomes and autophagosomes, mediates cytosol to cell wall exocytosis in Arabidopsis and tobacco cells. Plant Cell. 2010;22:4009–30.
Lin Y, DING Y, Wang J, Kung C-H, Zhuang X, Yin Z et al. EXPO and autophagosomes are distinct organelles in crops. Plant Physiol. 2015;169:pp.00953.2015.
Wang Y, Wu Y, Shen S, Liu Y, Xia Y, Xia H, et al. Engineered plant extracellular vesicles for pure supply throughout physiological limitations. Meals Funct. 2024;15:1737–57.
Cui Y, Cao W, He Y, Zhao Q, Wakazaki M, Zhuang X, et al. A complete-cell electron tomography mannequin of vacuole biogenesis in Arabidopsis root cells. Nat Vegetation. 2018;5:95–105.
Ito Y, Taniguchi Okay, Kuranaga Y, Eid N, Inomata Y, Lee S-W, et al. Uptake of MicroRNAs from Exosome-Like nanovesicles of edible plant juice by rat enterocytes. Int J Mol Sci. 2021;22:3749.
Hatsugai N, Iwasaki S, Tamura Okay, Kondo M, Fuji Okay, Ogasawara Okay, et al. A novel membrane fusion-mediated plant immunity in opposition to bacterial pathogens. Genes Dev. 2009;23:2496–506.
Manjithaya R, Anjard C, Loomis WF, Subramani S. Unconventional secretion of Pichia pastoris Acb1 depends on GRASP protein, peroxisomal features, and autophagosome formation. J Cell Biol. 2010;188:537–46.
Anderson CT, Kieber JJ. Dynamic building, notion, and transforming of plant cell partitions. Annu Rev Plant Biol. 2020;71:39–69.
Adani F, Papa G, Schievano A, Cardinale G, D’Imporzano G, Tambone F. Nanoscale construction of the cell wall defending cellulose from enzyme assault. Environ Sci Technol. 2011;45:1107–13.
de la Canal L, Pinedo M. Extracellular vesicles: a lacking element in plant cell wall transforming. J Exp Bot. 2018;69:4655–8.
Ruf A, Oberkofler L, Robatzek S, Weiberg A. Highlight on plant RNA-containing extracellular vesicles. Curr Opin Plant Biol. 2022;69:102272.
Brown L, Wolf JM, Prados-Rosales R, Casadevall A. By the wall: extracellular vesicles in Gram-positive micro organism, mycobacteria and fungi. Nat Rev Microbiol. 2015;13:620–30.
Berger E, Colosetti P, Jalabert A, Meugnier E, Wiklander OPB, Jouhet J, et al. Use of nanovesicles from orange juice to reverse Weight loss plan-Induced intestine modifications in Weight loss plan-Induced overweight mice. Mol Ther Strategies Clin Dev. 2020;18:880–92.
Ye L, Gao Y, Mok SWF, Liao W, Wang Y, Chen C, et al. Modulation of alveolar macrophage and mitochondrial health by medicinal plant-derived nanovesicles to mitigate acute lung damage and viral pneumonia. J Nanobiotechnol. 2024;22:190.
Wang J, Zhang T, Gu R, Ke Y, Zhang S, Su X, et al. Growth and analysis of reconstructed nanovesicles from turmeric for multifaceted weight problems intervention. ACS Nano. 2024;18:23117–35.
Zhang Y, Zhang X, Kai T, Zhang L, Li A. Lycium ruthenicum Murray derived exosome-like nanovesicles inhibit Aβ-induced apoptosis in PC12 cells by way of MAPK and PI3K/AKT signaling pathways. Int J Biol Macromol. 2024;277:134309.
Sabatke B, Rossi IV, Sana A, Bonato LB, Ramirez MI. Extracellular vesicles biogenesis and uptake ideas: A complete information to finding out host–pathogen communication. Mol Microbiol. 2024;122:613–29.https://onlinelibrary.wiley.com/doi/10.1111/mmi.15168
Gurung S, Perocheau D, Touramanidou L, Baruteau J. The exosome journey: from biogenesis to uptake and intracellular signalling. Cell Commun Sign. 2021;19:47.
Itakura S, Shohji A, Amagai S, Kitamura M, Takayama Okay, Sugibayashi Okay, et al. Gene knockdown in HaCaT cells by small interfering RNAs entrapped in grapefruit-derived extracellular vesicles utilizing a microfluidic machine. Sci Rep. 2023;13:3102.
Zheng M, Chavda VP, Vaghela DA, Bezbaruah R, Gogoi NR, Patel Okay, et al. Plant-derived exosomes in therapeutic nanomedicine, paving the trail towards precision drugs. Phytomedicine. 2024;135: 156087.
Chaya T, Banerjee A, Rutter BD, Adekanye D, Ross J, Hu G, et al. The extracellular vesicle proteomes of Sorghum bicolor and Arabidopsis Thaliana are partially conserved. Plant Physiol. 2024;194:1481–97.
Jokhio S, Peng I, Peng C-A. Extracellular vesicles remoted from Arabidopsis Thaliana leaves reveal traits of mammalian exosomes. Protoplasma. 2024;261:1025–33.
Vestuto V, Conte M, Vietri M, Mensitieri F, Santoro V, Di Muro A, et al. Multiomic profiling and neuroprotective bioactivity of salvia furry root-derived extracellular vesicles in a mobile mannequin of parkinson’s illness. Int J Nanomedicine. 2024;19:9373–93.
Liu N-J, Wang N, Bao J-J, Zhu H-X, Wang L-J, Chen X-Y. Lipidomic evaluation reveals the significance of GIPCs in Arabidopsis leaf extracellular vesicles. Mol Plant. 2020;13:1523–32.
Wang S, He B, Wu H, Cai Q, Ramírez-Sánchez O, Abreu-Goodger C, et al. Plant mRNAs transfer right into a fungal pathogen by way of extracellular vesicles to scale back an infection. Cell Host Microbe. 2024;32:93–e1056.
Zhou S, Huang P, Cao Y, Hua X, Yang Y, Liu S. Garlic-Derived Exosome-like Nanovesicles-Based mostly wound dressing for Staphylococcus aureus an infection visualization and therapy. ACS Appl Bio Mater. 2024;7:1888–98.
Shkryl Y, Tsydeneshieva Z, Menchinskaya E, Rusapetova T, Grishchenko O, Mironova A, et al. Exosome-like nanoparticles, excessive in Trans-δ-Viniferin derivatives, produced from grape cell cultures: preparation, characterization, and anticancer properties. Biomedicines. 2024;12:2142.
Yang M, Luo Q, Chen X, Chen F. Bitter melon derived extracellular vesicles improve the therapeutic results and cut back the drug resistance of 5-fluorouracil on oral squamous cell carcinoma. J Nanobiotechnol. 2021;19:259. https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-021-00995-1
Karamanidou T, Krommydas Okay, Karanikou M, Tsamos D, Michalakis Okay, Kletsas D, et al. Organic actions of Citrus-derived extracellular vesicles on human cells: the function of preservation. Curr Points Mol Biol. 2024;46:5812–24.
Chincinska IA. Leaf infiltration in plant science: previous technique, new potentialities. Plant Strategies. 2021;17:83.
Freire FBS, Morais EG, Daloso DM. Towards the Apoplast metabolome: Establishing a leaf Apoplast assortment strategy appropriate for metabolomics evaluation. Plant Physiol Biochem. 2024;215:109080.
Dora S, Terrett OM, Sánchez-Rodríguez C. Plant–microbe interactions within the apoplast: communication on the plant cell wall. Plant Cell. 2022;34:1532–50.
Regente M, Corti-Monzón G, Maldonado AM, Pinedo M, Jorrín J, de la Canal L. Vesicular fractions of sunflower apoplastic fluids are related to potential exosome marker proteins. FEBS Lett. 2009;583:3363–6.
Rutter B, Rutter Okay, Innes R. Isolation and quantification of plant extracellular vesicles. Bio-Protocol. 2017;7: e2533.
Adekanye D, Chaya T, Caplan J. Sorghum bicolor extracellular vesicle isolation, labeling, and correlative mild and electron microscopy. BIO-PROTOCOL. 2024;14: e5083.
Kingsbury NJ, McDonald KA. Quantitative analysis of E1 endoglucanase restoration from tobacco leaves utilizing the vacuum infiltration-centrifugation technique. Biomed Res Int. 2014;2014:1–10.
Kilasoniya A, Garaeva L, Shtam T, Spitsyna A, Putevich E, Moreno-Chamba B, et al. Potential of plant exosome vesicles from grapefruit (Citrus × paradisi) and tomato (Solanum lycopersicum) juices as useful substances and focused drug supply automobiles. Antioxidants. 2023;12:943.
Ye C, Yan C, Bian S-J, Li X-R, Li Y, Wang Okay-X, et al. Momordica charantia L.-derived exosome-like nanovesicles stabilize p62 expression to ameliorate doxorubicin cardiotoxicity. J Nanobiotechnol. 2024;22:464.https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-024-02705-z
Wang J, Ran B, Ma W, Teng Y, Bello MG, Chen L, et al. Growth of ginger-derived extracellular vesicles thermosensitive gel for UVA-induced photodamage of pores and skin. J Drug Supply Sci Technol. 2024;96:105649.
Zeng Y-B, Deng X, Shen L-S, Yang Y, Zhou X, Ye L, et al. Advances in plant-derived extracellular vesicles: isolation, composition, and organic features. Meals Funct. 2024;15:11319–41. https://pubs.rsc.org/en/content material/articlelanding/2024/fo/d4fo04321a
Liu Y, Wu S, Koo Y, Yang A, Dai Y, Khant H, et al. Characterization of and isolation strategies for plant leaf nanovesicles and small extracellular vesicles. Nanomed Nanotechnol Biol Med. 2020;29:102271.
Ferber E, Gerhards J, Sauer M, Krischke M, Dittrich MT, Müller T, et al. Chemical Priming by Isothiocyanates Protects Towards Intoxication by Merchandise of the Mustard Oil Bomb. Entrance Plant Sci. 2020;11:887.https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2020.00887/full
Garaeva L, Kamyshinsky R, Kil Y, Varfolomeeva E, Verlov N, Komarova E, et al. Supply of useful exogenous proteins by plant-derived vesicles to human cells in vitro. Sci Rep. 2021;11:6489.
Gao Y, Dong Y, Guo Q, Wang H, Feng M, Yan Z, et al. Research on supramolecules in conventional Chinese language drugs decoction. Molecules. 2022;27:3268.
Li T, Wang H, Bi W, Su Y, Xiong Y, Wang S, et al. Nano-characterization, composition evaluation, and anti inflammatory exercise of American-ginseng-derived vesicle-like nanoparticles. Molecules. 2024;29:3443.
Li X, Liang Z, Du J, Wang Z, Mei S, Li Z, et al. Natural decoctosome is a novel type of drugs. Sci China Life Sci. 2019;62:333–48.
Sánchez‐López CM, Soler C, Garzo E, Fereres A, Pérez‐Bermúdez P, Marcilla A. Phloem sap from melon crops comprises extracellular vesicles that carry lively proteasomes which enhance in response to aphid infestation. J Extracell Vesicles. 2024;13: e12517.
Altıntaş Ö, Saylan Y. Exploring the flexibility of exosomes: A evaluate on isolation, characterization, detection strategies, and various purposes. Anal Chem. 2023;95:16029–48.
Rivero-Pino F, Marquez-Paradas E, Montserrat-de la Paz S. Meals-derived vesicles as Immunomodulatory drivers: present information, gaps, and views. Meals Chem. 2024;457:140168.
Clos-Sansalvador M, Monguió-Tortajada M, Roura S, Franquesa M, Borràs FE. Generally used strategies for extracellular vesicles’ enrichment: implications in downstream analyses and use. Eur J Cell Biol. 2022;101:151227.
Wang W, Solar H, Duan H, Sheng G, Tian N, Liu D, et al. Isolation and utilization of exosomes in central nervous system illnesses. CNS Neurosci Ther. 2024;30: e14677.
Huang Y, Wang S, Cai Q, Jin H. Efficient strategies for isolation and purification of extracellular vesicles from crops. J Integr Plant Biol. 2021;63:2020–30.
Cui W-W, Ye C, Wang Okay-X, Yang X, Zhu P-Y, Hu Okay, et al. Momordica. charantia-derived extracellular vesicles-like nanovesicles shield cardiomyocytes in opposition to radiation damage by way of attenuating DNA injury and mitochondria dysfunction. Entrance Cardiovasc Med. 2022;9:864188.
Rutter BD, Innes RW. Rising pains: addressing the pitfalls of plant extracellular vesicle analysis. New Phytol. 2020;228:1505–10.
Jia Y, Yu L, Ma T, Xu W, Qian H, Solar Y, et al. Small extracellular vesicles isolation and separation: present methods, pending questions and scientific purposes. Theranostics. 2022;12:6548–75.
Grenhas M, Lopes R, Ferreira BV, Barahona F, João C, Carneiro EA. Dimension-Exclusion chromatography: A path to increased yield and reproducibility in comparison with sucrose cushion ultracentrifugation for extracellular vesicle isolation in a number of myeloma. Int J Mol Sci. 2024;25:8496.
Sidhom Okay, Obi PO, Saleem A. A evaluate of Exosomal isolation strategies: is measurement exclusion chromatography the best choice?? Int J Mol Sci. 2020;21:6466.
Guo J, Wu C, Lin X, Zhou J, Zhang J, Zheng W, et al. Institution of a simplified dichotomic size-exclusion chromatography for isolating extracellular vesicles towards scientific purposes. J Extracell Vesicles. 2021;10:e12145.
Patel U, Susman D, Allan AL. High quality management and validation of extracellular vesicles remoted from cultured human breast most cancers cells. BMC Res Notes. 2024;17:202.
Yu J, Huang D, Liu H, Cai H. Optimizing situations of polyethylene glycol precipitation for exosomes isolation from MSCs tradition media for regenerative therapy. Biotechnol J. 2024;19:e202400374.
Kalarikkal SP, Prasad D, Kasiappan R, Chaudhari SR, Sundaram GM. A cheap polyethylene glycol-based technique for the isolation of useful edible nanoparticles from ginger rhizomes. Sci Rep. 2020;10:4456.
Zhang J, Zhou C, Tan M, Cao Y, Ren Y, Peng L. Optimization and characterization of PEG extraction course of for Tartary Buckwheat-Derived nanoparticles. Meals. 2024;13:2624.
Ing TS. Remoted ultrafiltration: its origin and early improvement. Artif Organs. 2013;37:841–7.
You JY, Kang SJ, Rhee WJ. Isolation of cabbage exosome-like nanovesicles and investigation of their organic actions in human cells. Bioact Mater. 2021;6:4321–32.
Kırbaş OK, Sağraç D, Çiftçi ÖC, Özdemir G, Öztürkoğlu D, Bozkurt BT, et al. Unveiling the potential: extracellular vesicles from plant cell suspension cultures as a promising supply. BioFactors. 2025;51:e2090.
Liangsupree T, Multia E, Riekkola M-L. Trendy isolation and separation methods for extracellular vesicles. J Chromatogr A. 2021;1636: 461773.
Al-Madhagi H. The panorama of exosomes biogenesis to scientific purposes. Int J Nanomed. 2024;19:3657–75.
Liu N, Hou L, Chen X, Bao J, Chen F, Cai W, et al. Arabidopsis TETRASPANIN8 mediates exosome secretion and Glycosyl inositol phosphoceramide sorting and trafficking. Plant Cell. 2024;36:626–41.
He B, Cai Q, Qiao L, Huang C-Y, Wang S, Miao W, et al. RNA-binding proteins contribute to small RNA loading in plant extracellular vesicles. Nat Vegetation. 2021;7:342–52.
Wen Z, Yu J, Jeong H, Kim D-U, Yang JY, Hyun Okay-A, et al. An all-in-one platform to deplete pathogenic micro organism for speedy and protected enrichment of plant-derived extracellular vesicles. Lab Chip. 2023;23:4483–92.
Steć A, Chodkowska M, Kasprzyk-Pochopień J, Mielczarek P, Piekoszewski W, Lewczuk B, et al. Isolation of citrus lemon extracellular vesicles: improvement and course of management utilizing capillary electrophoresis. Meals Chem. 2023;424:136333.
Schröder S, Zhang H, Yeung ES, Jänsch L, Zabel C, Wätzig H. Quantitative gel electrophoresis: sources of variation. J Proteome Res. 2008;7:1226–34.
Woith E, Melzig MF. Extracellular vesicles from contemporary and dried Vegetation—Simultaneous purification and visualization utilizing gel electrophoresis. Int J Mol Sci. 2019;20:357.
Yang M, Liu X, Luo Q, Xu L, Chen F. An environment friendly technique to isolate lemon derived extracellular vesicles for gastric most cancers remedy. J Nanobiotechnol. 2020;18: 100.
Rhim W-Okay, Kim JY, Lee SY, Cha S-G, Park JM, Park HJ, et al. Current advances in extracellular vesicle engineering and its purposes to regenerative drugs. Biomater Res. 2023;27:130.
Kim MK, Choi YC, Cho SH, Choi JS, Cho YW. The antioxidant impact of small extracellular vesicles derived from Aloe vera peels for wound therapeutic. Tissue Eng Regen Med. 2021;18:561–71.
Kim WS, Ha J-H, Jeong S-H, Lee J-I, Lee B-W, Jeong YJ, et al. Immunological results of aster Yomena Callus-Derived extracellular vesicles as potential therapeutic brokers in opposition to allergic bronchial asthma. Cells. 2022;11:2805.
Sharma S, Mahanty M, Rahaman SG, Mukherjee P, Dutta B, Khan MI, et al. Avocado-derived extracellular vesicles loaded with Ginkgetin and Berberine forestall irritation and macrophage foam cell formation. J Cell Mol Med. 2024;28: e18177.
Aziz MA, Search engine optimization B, Hussaini HM, Hibma M, Wealthy AM. Evaluating two strategies for the isolation of exosomes. J Nucleic Acids. 2022;2022:8648373.
Taşlı PN. Utilization of celery root exosome as an immune suppressant; lipidomic characterization of apium graveolens originated exosomes and its suppressive impact on pma/ionomycin mediated CD4 + T lymphocyte activation. J Meals Biochem. 2022;46:e14393.
Jackson KK, Mata C, Marcus RK. A speedy capillary-channeled polymer (C-CP) fiber spin-down tip strategy for the isolation of plant-derived extracellular vesicles (PDEVs) from 20 widespread fruit and vegetable sources. Talanta. 2023;252:123779.
Ramírez O, Pomareda F, Olivares B, Huang Y-L, Zavala G, Carrasco-Rojas J, et al. Aloe vera peel-derived nanovesicles show anti-inflammatory properties and stop myofibroblast differentiation. Phytomedicine. 2024;122:155108.
De Palma M, Ambrosone A, Leone A, Del Gaudio P, Ruocco M, Turiák L, et al. Plant roots launch small extracellular vesicles with antifungal exercise. Vegetation. 2020;9:1777.
Buratta S, Latella R, Chiaradia E, Salzano AM, Tancini B, Pellegrino RM, et al. Characterization of nanovesicles remoted from olive vegetation water. Meals. 2024;13:835.
Suresh AP, Kalarikkal SP, Pullareddy B, Sundaram GM. Low pH-Based mostly technique to extend the yield of Plant-Derived nanoparticles from contemporary ginger rhizomes. ACS Omega. 2021;6:17635–41.
López de las Hazas M-C, Tomé-Carneiro J, del Pozo-Acebo L, del Saz-Lara A, Chapado LA, Balaguer L, et al. Therapeutic potential of plant-derived extracellular vesicles as nanocarriers for exogenous MiRNAs. Pharmacol Res. 2023;198:106999.
Ekanayake G, Piibor J, Midekessa G, Godakumara Okay, Dissanayake Okay, Andronowska A, et al. Systematic characterization of extracellular vesicles from potato (Solanum tuberosum cv. Laura) roots and peels: biophysical properties and proteomic profiling. Entrance Plant Sci. 2024;15:1477614.
Feng W, Teng Y, Zhong Q, Zhang Y, Zhang J, Zhao P, et al. Biomimetic Grapefruit-Derived extracellular vesicles for protected and focused supply of sodium thiosulfate in opposition to vascular calcification. ACS Nano. 2023;17:24773–89.
Valentino A, Conte R, Bousta D, Bekkari H, Di Salle A, Calarco A, et al. Extracellular vesicles derived from opuntia ficus-indica fruit (OFI-EVs) pace up the traditional wound therapeutic processes by modulating mobile responses. Int J Mol Sci. 2024;25:7103.
Yang R, Lin F, Wang W, Dai G, Ke X, Wu G. Investigating the therapeutic results and mechanisms of Carthamus tinctorius L.-derived nanovesicles in atherosclerosis therapy. Cell Commun Sign. 2024. https://doi.org/10.1186/s12964-024-01561-6.
Morris EJ, Kaur H, Dobhal G, Malhotra S, Ayed Z, Carpenter AL, et al. The bodily characterization of extracellular vesicles for operate Elucidation and biomedical purposes: A evaluate. Half Half Syst Char. 2024;41:2400024.
Ou X, Wang H, Tie H, Liao J, Luo Y, Huang W, et al. Novel plant-derived exosome-like nanovesicles from catharanthus roseus: preparation, characterization, and immunostimulatory impact by way of TNF-α/NF-κB/PU.1 axis. J Nanobiotechnology. 2023;21(1): 160.
Kankaanpää S, Väisänen E, Goeminne G, Soliymani R, Desmet S, Samoylenko A, et al. Extracellular vesicles of Norway Spruce include precursors and enzymes for lignin formation and Salicylic acid. Plant Physiol. 2024;196:788–809.
Liu B, Li X, Yu H, Shi X, Zhou Y, Alvarez S, et al. Therapeutic potential of Garlic chive-derived vesicle-like nanoparticles in NLRP3 inflammasome-mediated inflammatory illnesses. Theranostics. 2021;11:9311–30.
Sánchez-López CM, Manzaneque-López MC, Pérez-Bermúdez P, Soler C, Marcilla A. Characterization and bioactivity of extracellular vesicles remoted from pomegranate. Meals Funct. 2022;13:12870–82.
Rabienezhad Ganji N, Urzì O, Tinnirello V, Costanzo E, Polito G, Palumbo Piccionello A, et al. Proof-of-concept research on using Tangerine-derived nanovesicles as SiRNA supply automobiles towards colorectal most cancers cell line SW480. Int J Mol Sci. 2023. https://doi.org/10.3390/ijms25010546.
Pei J, Palanisamy CP, Jayaraman S, Natarajan PM, Umapathy VR, Roy JR, et al. Proteomics profiling of extracellular vesicle for identification of potential biomarkers in Alzheimer’s illness: a complete evaluate. Ageing Res Rev. 2024;99: 102359.
Zimmerman JA, Verboonen B, Harrison Hanson AP, Arballo LR, Brusslan JA. Arabidopsis Apoplast TET8 positively correlates to leaf senescence, and tet3tet8 double mutants are delayed in leaf senescence. Plant Direct. 2024;8:e70006.
Cai Q, Qiao L, Wang M, He B, Lin F-M, Palmquist J, et al. Vegetation ship small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes. Science. 2018;360:1126–9.
Eisenach C, Chen Z, Grefen C, Blatt MR. The trafficking protein SYP121 of Arabidopsis connects programmed stomatal closure and Okay+ channel exercise with vegetative development. Plant J. 2012;69:241–51.
Neves J, Monteiro J, Sousa B, Soares C, Pereira S, Fidalgo F, et al. Relevance of the exocyst in Arabidopsis exo70e2 mutant for mobile homeostasis below stress. Int J Mol Sci. 2022;24:424.
Larson ER, Ortmannová J, Donald NA, Alvim J, Blatt MR, Žárský V. Synergy amongst exocyst and SNARE interactions identifies a useful hierarchy in secretion throughout vegetative development. Plant Cell. 2020;32:2951–63.
Ortmannová J, Sekereš J, Kulich I, Šantrůček J, Dobrev P, Žárský V, et al. Arabidopsis EXO70B2 exocyst subunit contributes to papillae and encasement formation in antifungal defence. J Exp Bot. 2022;73:742–55.
Feng J, Xiu Q, Huang Y, Troyer Z, Li B, Zheng L. Plant-Derived Vesicle‐Like nanoparticles as promising biotherapeutic instruments: current and future. Adv Mater. 2023;35:2207826.
Wei Y, Cai X, Wu Q, Liao H, Liang S, Fu H, et al. Extraction, isolation, and element evaluation of Turmeric-Derived Exosome-like nanoparticles. Bioengineering. 2023;10:1199.
Buratta S, Urbanelli L, Tognoloni A, Latella R, Cerrotti G, Emiliani C, et al. Protein and lipid content material of milk extracellular vesicles: a comparative overview. Life (Basel). 2023;13:401.
Wang B, Zhuang X, Deng Z-B, Jiang H, Mu J, Wang Q, et al. Focused drug supply to intestinal macrophages by bioactive nanovesicles launched from grapefruit. Mol Ther. 2014;22:522–34.
Chen Z, Ho I-L, Soeung M, Yen E-Y, Liu J, Yan L, et al. Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis. Nat Commun. 2023;14:2194.
Lee H, Zhuang L, Gan B. Ether phospholipids govern ferroptosis. J Genet Genomics. 2021;48:517–9.
Chen X, Zhou Y, Yu J. Exosome-like nanoparticles from ginger rhizomes inhibited NLRP3 inflammasome activation. Mol Pharm. 2019;16:2690–9.
Kumar A, Sundaram Okay, Teng Y, Mu J, Sriwastva MK, Zhang L, et al. Ginger nanoparticles mediated induction of Foxa2 prevents high-fat diet-induced insulin resistance. Theranostics. 2022;12:1388–403.
Baldrich P, Rutter BD, Karimi HZ, Podicheti R, Meyers BC, Innes RW. Plant extracellular vesicles include various small RNA species and are enriched in 10- to 17-Nucleotide tiny RNAs. Plant Cell. 2019;31:315–24.
Xu X-H, Yuan T-J, Dad HA, Shi M-Y, Huang Y-Y, Jiang Z-H, et al. Plant exosomes as novel nanoplatforms for microRNA switch stimulate neural differentiation of stem cells in vitro and in vivo. Nano Lett. 2021;21:8151–9.
Shen H, Zhang M, Liu D, Liang X, Chang Y, Hu X, et al. Solanum lycopersicum derived exosome-like nanovesicles alleviate restenosis after vascular damage by means of the Keap1/Nrf2 pathway. Meals Funct. 2025;16:539–53. https://pubs.rsc.org/en/content material/articlelanding/2025/fo/d4fo03993a
Wang X, Wu B, Solar G, He W, Gao J, Huang T, et al. Selenium biofortification enhanced miR167a expression in broccoli extracellular vesicles inducing apoptosis in human pancreatic most cancers cells by focusing on IRS1. Int J Nanomed. 2023;18:2431–46.
Wu B, Pan W, Luo S, Luo X, Zhao Y, Xiu Q, et al. Turmeric‐Derived Nanoparticles Functionalized Aerogel Regulates Multicellular Networks to Promote Diabetic Wound Therapeutic. Adv Sci (Weinh). 2024;11:e2307630.https://pmc.ncbi.nlm.nih.gov/articles/PMC11095230/
Emmanuela N, Muhammad DR, Iriawati, Wijaya CH, Ratnadewi YMD, Takemori H, et al. Isolation of plant-derived exosome-like nanoparticles (PDENs) from solanum nigrum L. berries and their impact on interleukin-6 expression as a possible anti-inflammatory agent. PLoS ONE. 2024;19:e0296259.
Kim J, Gao C, Guo P, Sheng J, Wang J. A novel strategy to alleviate acetaminophen-induced hepatotoxicity with hybrid balloon flower root-derived exosome-like nanoparticles (BDEs) with Silymarin by way of Inhibition of hepatocyte MAPK pathway and apoptosis. Cell Commun Sign. 2024;22:334.
Kocholatá M, Malý J, Kříženecká S, Janoušková O. Range of extracellular vesicles derived from calli, cell tradition and apoplastic fluid of tobacco. Sci Rep. 2024;14:30111.
Peng X, Cheng L, You Y, Tang C, Ren B, Li Y, et al. Oral microbiota in human systematic illnesses. Int J Oral Sci. 2022;14:14.
Meyle J, Chapple I. Molecular points of the pathogenesis of periodontitis. Periodontol 2000. 2015;69:7–17.
Lee B-H, Wu S-C, Chien H-Y, Shen T-L, Hsu W-H. Tomato-fruit-derived extracellular vesicles inhibit Fusobacterium nucleatum by way of lipid-mediated mechanism. Meals Funct. 2023;14:8942–50.
Tan S, Liu Z, Cong M, Zhong X, Mao Y, Fan M, et al. Dandelion-derived vesicles-laden hydrogel dressings able to neutralizing Staphylococcus aureus exotoxins for the care of invasive wounds. J Managed Launch. 2024;368:355–71.
Teng Y, Ren Y, Sayed M, Hu X, Lei C, Kumar A, et al. Plant-Derived Exosomal MicroRNAs form the intestine microbiota. Cell Host Microbe. 2018;24:637–e6528.
Liu Y, Tan M-L, Zhu W-J, Cao Y-N, Peng L-X, Yan Z-Y, et al. In vitro results of Tartary Buckwheat-Derived nanovesicles on intestine microbiota. J Agric Meals Chem. 2022;70:2616–29.
Zhu M, Xu H, Liang Y, Xu J, Yue N, Zhang Y, et al. Edible exosome-like nanoparticles from portulaca oleracea L mitigate DSS-induced colitis by way of facilitating double-positive CD4 + CD8 + T cells enlargement. J Nanobiotechnology. 2023;21: 309.
Sriwastva MK, Deng Z, Wang B, Teng Y, Kumar A, Sundaram Okay, et al. Exosome-like nanoparticles from mulberry bark forestall DSS‐induced colitis by way of the AhR/COPS8 pathway. EMBO Rep. 2022;23:e53365.
Zhu Z, Liao L, Gao M, Liu Q. Garlic-derived exosome-like nanovesicles alleviate dextran sulphate sodium-induced mouse colitis by way of the TLR4/MyD88/NF-κB pathway and intestine microbiota modulation. Meals Funct. 2023;14:7520–34.
Kim J, Zhang S, Zhu Y, Wang R, Wang J. Amelioration of colitis development by ginseng-derived exosome-like nanoparticles by means of suppression of inflammatory cytokines. J Ginseng Res. 2023;47:627–37.
Zhao X, Yin F, Fu L, Ma Y, Ye L, Huang Y, et al. Garlic-derived exosome-like nanovesicles as a hepatoprotective agent assuaging acute liver failure by inhibiting CCR2/CCR5 signaling and irritation. Biomater Adv. 2023;154:213592.
Vanessa V, Rachmawati H, Barlian A. Anti-inflammatory potential of goldenberry-derived exosome-like nanoparticles in macrophage polarization. Future Sci OA. 2024;10:FSO943.
Yan L, Cao Y, Hou L, Luo T, Li M, Gao S, et al. Ginger exosome-like nanoparticle-derived MiRNA therapeutics: A strategic inhibitor of intestinal irritation. J Adv Res. 2024;S2090–1232(24):00130–9.
Qiu F-S, Wang J-F, Guo M-Y, Li X-J, Shi C-Y, Wu F, et al. Rgl-exomiR-7972, a novel plant Exosomal MicroRNA derived from contemporary rehmanniae radix, ameliorated lipopolysaccharide-induced acute lung damage and intestine dysbiosis. Biomed Pharmacother. 2023;165:115007.
Wu J, Ma X, Lu Y, Zhang T, Du Z, Xu J, et al. Edible pueraria lobata-Derived exosomes promote M2 macrophage polarization. Molecules. 2022;27:8184.
Gao C, Zhou Y, Chen Z, Li H, Xiao Y, Hao W, et al. Turmeric-derived nanovesicles as novel nanobiologics for focused remedy of ulcerative colitis. Theranostics. 2022;12:5596–614.
Han R, Zhou D, Ji N, Yin Z, Wang J, Zhang Q, et al. Folic acid-modified ginger-derived extracellular vesicles for focused therapy of rheumatoid arthritis by transforming immune microenvironment by way of the PI3K-AKT pathway. J Nanobiotechnol. 2025;23:41.
Deng Z, Rong Y, Teng Y, Mu J, Zhuang X, Tseng M, et al. Broccoli-Derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-Activated protein kinase. Mol Ther. 2017;25:1641–54.
Xu J, Yu Y, Zhang Y, Dai H, Yang Q, Wang B, et al. Oral administration of garlic-derived nanoparticles improves most cancers immunotherapy by inducing intestinal IFNγ-producing γδ T cells. Nat Nanotechnol. 2024;19:1569–78.
Zhang M, Viennois E, Prasad M, Zhang Y, Wang L, Zhang Z, et al. Edible ginger-derived nanoparticles: A novel therapeutic strategy for the prevention and therapy of inflammatory bowel illness and colitis-associated most cancers. Biomaterials. 2016;101:321–40.
Yin L, Yan L, Yu Q, Wang J, Liu C, Wang L, et al. Characterization of the MicroRNA profile of ginger Exosome-like nanoparticles and their Anti-Inflammatory results in intestinal Caco-2 cells. J Agric Meals Chem. 2022;70:4725–34.
Teng Y, Xu F, Zhang X, Mu J, Sayed M, Hu X, et al. Plant-derived Exosomal MicroRNAs inhibit lung irritation induced by exosomes SARS-CoV-2 Nsp12. Mol Ther. 2021;29:2424–40.
Liu J, Li W, Bian Y, Jiang X, Zhu F, Yin F, et al. Garlic-derived exosomes regulate PFKFB3 expression to alleviate liver dysfunction in high-fat diet-fed mice by way of macrophage-hepatocyte crosstalk. Phytomedicine. 2023;112:154679.
Trentini M, Zanotti F, Tiengo E, Camponogara F, Degasperi M, Licastro D, et al. An Apple a day retains the Physician away: potential function of MiRNA 146 on macrophages handled with exosomes derived from apples. Biomedicines. 2022;10:415.
Trentini M, Zanolla I, Zanotti F, Tiengo E, Licastro D, Dal Monego S, et al. Apple derived exosomes enhance collagen sort I manufacturing and reduce MMPs throughout ageing of the pores and skin by means of downregulation of the NF-κB. Pathw as Mode Motion Cells. 2022;11:3950.
Tinnirello V, Zizzo MG, Conigliaro A, Tabone M, Ganji NR, Cicio A, et al. Industrial-produced lemon nanovesicles ameliorate experimental colitis-associated damages in rats by way of the activation of anti-inflammatory and antioxidant responses and microbiota modification. Biomed Pharmacother. 2024;174:116514.
Raimondo S, Urzì O, Meraviglia S, Di Simone M, Corsale AM, Rabienezhad Ganji N, et al. Anti-inflammatory properties of lemon-derived extracellular vesicles are achieved by means of the Inhibition of ERK/NF-κB signalling pathways. J Cell Mol Med. 2022;26:4195–209.
Liu B, Lu Y, Chen X, Muthuraj PG, Li X, Pattabiraman M, et al. Protecting function of Shiitake Mushroom-Derived Exosome-Like nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced acute liver damage in mice. Vitamins. 2020;12:477.
Ma L, Ye Z, Guo D, Nie C, Zhou Z. Citri reticulate pericranium-derived extracellular vesicles exert antioxidant and anti inflammatory properties and improve the bioactivity of nobiletin by forming EVs-nob nanoparticles. Entrance Cell Dev Biol. 2024;12:1509123.
Liu C, Yan X, Zhang Y, Yang M, Ma Y, Zhang Y, et al. Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis remedy. J Nanobiotechnol. 2022;20:206.
Zhang X, Pan Z, Wang Y, Liu P, Hu Okay. Taraxacum officinale-derived exosome-like nanovesicles modulate intestine metabolites to stop intermittent hypoxia-induced hypertension. Biomed Pharmacother. 2023;161:114572.
Eom J-Y, Choi S-H, Kim H-J, Kim D, Bae J-H, Kwon G-S, et al. Hemp-Derived nanovesicles shield leaky intestine and liver damage in dextran sodium Sulfate-Induced colitis. Int J Mol Sci. 2022;23:9955.
Martínez Fajardo C, Morote L, Moreno-Giménez E, López-López S, Rubio-Moraga Á, Díaz-Guerra MJM, et al. Exosome-like nanoparticles from Arbutus Unedo L. mitigate LPS-induced irritation by way of JAK-STAT inactivation. Meals Funct. 2024;15:11280–90.
Zeng Y, Yu S, Lu L, Zhang J, Xu C. Ginger-derived nanovesicles attenuate osteoarthritis development by inhibiting oxidative stress by way of the Nrf2 pathway. Nanomed. 2024;19:2357–73.
Zhuang X, Deng Z, Mu J, Zhang L, Yan J, Miller D, et al. Ginger-derived nanoparticles shield in opposition to alcohol-induced liver injury. J Extracell Vesicles. 2015. https://doi.org/10.3402/jev.v4.28713.
Zhao W, Bian Y, Wang Q, Yin F, Yin L, Zhang Y, et al. Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver illness by attenuating mitochondrial oxidative stress. Acta Pharmacol Sin. 2022;43:645–58.
Zhang Y, Lu L, Li Y, Liu H, Zhou W, Zhang L. Response floor methodology optimization of Exosome-like nanovesicles extraction from lycium ruthenicum Murray and their inhibitory results on Aβ-Induced apoptosis and oxidative stress in HT22 cells. Meals. 2024;13:3328.
Kim DK, Rhee WJ. Antioxidative results of carrot-derived nanovesicles in cardiomyoblast and neuroblastoma cells. Pharmaceutics. 2021;13:1203.
Wang F, Yuan M, Shao C, Ji N, Zhang H, Li C. Momordica charantia-derived extracellular vesicles present antioxidant safety in ulcerative colitis. Molecules. 2023;28:6182.
Wang J, Xie F, He Q, Gu R, Zhang S, Su X, et al. Hybrid nanovesicles derived from grapes and tomatoes with synergistic antioxidative exercise. Biomater Sci. 2024;12:5631–43.
Wang D, Zhang H, Liao X, Li J, Zeng J, Wang Y, et al. Oral administration of Robinia Pseudoacacia L. flower exosome-like nanoparticles attenuates gastric and small intestinal mucosal ferroptosis brought on by hypoxia by means of inhibiting HIF-1α- and HIF-2α-mediated lipid peroxidation. J Nanobiotechnol. 2024;22:479.
Kim J-S, Eom J-Y, Kim H-W, Ko J-W, Hong E-J, Kim M-N, et al. Hemp sprout-derived exosome-like nanovesicles as hepatoprotective brokers attenuate liver fibrosis. Biomater Sci. 2024;12:5361–71.
Kim J-S, Kim D, Gil M-C, Kwon H-J, Search engine optimization W, Kim D-Okay, et al. Pomegranate-Derived Exosome-Like nanovesicles alleviate binge Alcohol-Induced leaky intestine and liver damage. J Med Meals. 2023;26:739–48.
Choi W, Cho JH, Park SH, Kim DS, Lee HP, Kim D, et al. Ginseng root-derived exosome-like nanoparticles shield pores and skin from UV irradiation and oxidative stress by suppressing activator protein-1 signaling and limiting the technology of reactive oxygen species. J Ginseng Res. 2024;48:211–9.
Baldini N, Torreggiani E, Roncuzzi L, Perut F, Zini N, Avnet S. Exosome-like nanovesicles remoted from citrus Limon L. Exert antioxidative impact. CPB. 2018;19:877–85.
Lei X, Li H, Chen S, Li B, Xia H, Li J, et al. Tea leaf exosome-like nanoparticles (TELNs) enhance oleic acid-induced lipid metabolism by regulating MiRNAs in HepG-2 cells. Bioresour Bioprocess. 2025;12:9.
Perut F, Roncuzzi L, Avnet S, Massa A, Zini N, Sabbadini S, et al. Strawberry-Derived Exosome-Like nanoparticles forestall oxidative stress in human mesenchymal stromal cells. Biomolecules. 2021;11:87.
De Robertis M, Sarra A, D’Oria V, Mura F, Bordi F, Postorino P, et al. Blueberry-Derived Exosome-Like nanoparticles counter the response to TNF-α-Induced change on gene expression in EA.hy926 cells. Biomolecules. 2020;10:742.
Naselli F, Volpes S, Cardinale PS, Palumbo FS, Cancilla F, Lopresti F, et al. New nanovesicles from prickly Pear fruit juice: A useful resource with antioxidant, Anti-Inflammatory, and nutrigenomic properties. Cells. 2024;13:1756.
Ju S, Mu J, Dokland T, Zhuang X, Wang Q, Jiang H, et al. Grape Exosome-like nanoparticles induce intestinal stem cells and shield mice from DSS-Induced colitis. Mol Ther. 2013;21:1345–57.
Kim M, Park JH. Isolation of Aloe saponaria-Derived extracellular vesicles and investigation of their potential for continual wound therapeutic. Pharmaceutics. 2022;14:1905.
Kim H, Shin H, Park M, Ahn Okay, Kim S-J, An S-H. Exosome-Like vesicles from Lithospermum erythrorhizon callus enhanced wound therapeutic by decreasing LPS-Induced irritation. J Microbiol Biotechnol. 2024;35:e2410022.
Savcı Y, Kırbaş OK, Bozkurt BT, Abdik EA, Taşlı PN, Şahin F, et al. Grapefruit-derived extracellular vesicles as a promising cell-free therapeutic device for wound therapeutic. Meals Funct. 2021;12:5144–56.
Şahin F, Koçak P, Güneş MY, Özkan İ, Yıldırım E, Kala EY. In vitro wound therapeutic exercise of wheat-derived nanovesicles. Appl Biochem Biotechnol. 2019;188:381–94.
Search engine optimization Okay, Yoo JH, Kim J, Min SJ, Heo DN, Kwon IK, et al. Ginseng-derived exosome-like nanovesicles extracted by sucrose gradient ultracentrifugation to inhibit osteoclast differentiation. Nanoscale. 2023;15:5798–808.
Park Y-S, Kim H-W, Hwang J-H, Eom J-Y, Kim D-H, Park J, et al. Plum-Derived Exosome-like nanovesicles induce differentiation of osteoblasts and discount of osteoclast activation. Vitamins. 2023;15:2107.
Hwang J-H, Park Y-S, Kim H-S, Kim D, Lee S-H, Lee C-H, et al. Yam-derived exosome-like nanovesicles stimulate osteoblast formation and stop osteoporosis in mice. J Managed Launch. 2023;355:184–98.
Sim Y, Search engine optimization H-J, Kim D, Lee S-H, Kwon J, Kwun I-S, et al. The impact of Apple-Derived nanovesicles on the osteoblastogenesis of osteoblastic MC3T3-E1 cells. J Med Meals. 2023;26:49–58.
Zhan W, Deng M, Huang X, Xie D, Gao X, Chen J, et al. Pueraria lobata-derived exosome-like nanovesicles alleviate osteoporosis by enhacning autophagy. J Managed Launch. 2023;364:644–53.
Zhao Q, Feng J, Liu F, Liang Q, Xie M, Dong J, et al. Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells by way of focusing on period signaling. Acta Pharm Sinica B. 2024;14:2210–27.
Di Stefano M, Polizzi A, Santonocito S, Romano A, Lombardi T, Isola G. Affect of oral Microbiome in periodontal well being and periodontitis: A vital evaluate on prevention and therapy. Int J Mol Sci. 2022;23:5142.
Hajishengallis G, Lamont RJ. Past the crimson advanced and into extra complexity: the polymicrobial synergy and dysbiosis (PSD) mannequin of periodontal illness etiology. Mol Oral Microbiol. 2012;27:409–19.
Gasmi A, Gasmi Benahmed A, Noor S, Mujawdiya P. Porphyromonas gingivalis within the improvement of periodontitis: impression on dysbiosis and irritation. Arch Razi Inst. 2022;77:1539–51.
Signat B, Roques C, Poulet P, Duffaut D. Fusobacterium nucleatumin periodontal well being and illness. Curr Points Mol Biol. 2011;13:25–36.
Liu H, Liu Y, Fan W, Fan B. Fusobacterium nucleatum triggers Proinflammatory cell dying by way of Z-DNA binding protein 1 in apical periodontitis. Cell Commun Sign. 2022;20:196.
Veras EL, Castro dos Santos N, Souza JGS, Figueiredo LC, Retamal-Valdes B, Barão VAR, et al. Newly recognized pathogens in periodontitis: proof from an affiliation and an elimination research. J Oral Microbiol. 2023;15:2213111.
Kim S, Lee JY, Park J-Y, Kim Y, Kang C-H. Lacticaseibacillus rhamnosus MG4706 suppresses periodontitis in osteoclasts, Irritation-Inducing cells, and Ligature-Induced rats. Vitamins. 2022;14:4869.
Zhou Okay, Xie J, Su Y, Fang J. Lactobacillus reuteri for continual periodontitis: deal with underlying mechanisms and future views. Biotechnol Genet Eng Rev. 2023;40:1–28.
Naureen Z, Medori MC, DHULI Okay, Donato Okay, Connelly ST, Bellinato F, et al. Polyphenols and Lactobacillus reuteri in oral well being. J Prev Med Hyg. 2022;63:E246–54.
Han N, Liu Y, Du J, Xu J, Guo L, Liu Y. Regulation of the host immune microenvironment in periodontitis and periodontal bone transforming. Int J Mol Sci. 2023;24: 3158.
Wang W, Zheng C, Yang J, Li B. Intersection between macrophages and periodontal pathogens in periodontitis. J Leukoc Biol. 2021;110:577–83.
Jiang J, Wang F, Huang W, Solar J, Ye Y, Ou J, et al. Cellular mechanical sign generator for macrophage polarization. Exploration. 2023;3:20220147.
Yang L, Tao W, Xie C, Chen Q, Zhao Y, Zhang L, et al. Interleukin-37 ameliorates periodontitis improvement by inhibiting NLRP3 inflammasome activation and modulating M1/M2 macrophage polarization. J Periodontal Res. 2023;59:128–39.
Liu Q, Zhang J, Liu X, Gao J. Position of development hormone in maturation and activation of dendritic cells by way of miR‐200a and the Keap1/Nrf2 pathway. Cell Prolif. 2015;48:573–81.
El-Awady AR, Elashiry M, Morandini AC, Meghil MM, Cutler CW. Dendritic cells a vital hyperlink to alveolar bone loss and systemic illness danger in periodontitis: Immunotherapeutic implications. Periodontol. 2000. 2022;89:41–50.
Meghil MM, Ghaly M, Cutler CW. A Story of two fimbriae: how invasion of dendritic cells by Porphyromonas gingivalis disrupts DC maturation and depolarizes the T-Cell-Mediated immune response. Pathogens. 2022;11:328.
Wu L, Luo Z, Chen Y, Yan Z, Fu J, Jiang Y, et al. Butyrate inhibits dendritic cell activation and alleviates periodontitis. J Dent Res. 2023;102:1326–36.
Figueredo CM, Lira-Junior R, Love RM. T and B cells in periodontal illness: new features in A fancy state of affairs. Int J Mol Sci. 2019;20:3949.
Zhu H, He W. Ginger: a consultant materials of herb-derived exosome-like nanoparticles. Entrance Nutr. 2023;10:1223349.
Sczepanik FSC, Grossi ML, Casati M, Goldberg M, Glogauer M, Positive N, et al. Periodontitis is an inflammatory illness of oxidative stress: we must always deal with it that manner. Periodontol 2000. 2020;84:45–68.
Pouliou C, Piperi C. Advances of oxidative stress impression in periodontitis: biomarkers and efficient focusing on choices. Curr Med Chem. 2024;31:6187–203.
Hajam YA, Rani R, Ganie SY, Sheikh TA, Javaid D, Qadri SS, et al. Oxidative stress in human pathology and ageing: molecular mechanisms and views. Cells. 2022;11:552.
Wang Y, Andrukhov O, Rausch-Fan X. Oxidative stress and antioxidant system in periodontitis. Entrance Physiol. 2017;8:910.
Ying S, Tan M, Feng G, Kuang Y, Chen D, Li J, et al. Low-intensity pulsed ultrasound regulates alveolar bone homeostasis in experimental periodontitis by diminishing oxidative stress. Theranostics. 2020;10:9789–807.
Zhu Y, Zhao J, Ding H, Qiu M, Xue L, Ge D, et al. Functions of plant-derived extracellular vesicles in drugs. MedComm. 2024. https://doi.org/10.1002/mco2.741.
He F, Ru X, Wen T. NRF2, a transcription issue for stress response and past. Int J Mol Sci. 2020;21:4777.
Kahroba H, Davatgaran-Taghipour Y. Exosomal Nrf2: from anti-oxidant and anti-inflammation response to wound therapeutic and tissue regeneration in aged-related illnesses. Biochimie. 2020;171–172:103–9.
Xu T, Xie Okay, Wang C, Ivanovski S, Zhou Y. Immunomodulatory nanotherapeutic approaches for periodontal tissue regeneration. Nanoscale. 2023;15:5992–6008.
de Jong T, Bakker AD, Everts V, Smit TH. The intricate anatomy of the periodontal ligament and its improvement: classes for periodontal regeneration. J Periodontal Res. 2017;52:965–74.
Hienz SA, Paliwal S, Ivanovski S. Mechanisms of bone resorption in periodontitis. J Immunol Res. 2015;2015:1–10.
Artese L, Piattelli A, de Gouveia Cardoso LA, Ferrari DS, Onuma T, Piccirilli M, et al. Immunoexpression of angiogenesis, nitric oxide synthase, and proliferation markers in gingival samples of sufferers with aggressive and continual periodontitis. J Periodontol. 2010;81:718–26.
Mohd Nor NH, Berahim Z, Azlina A, Mokhtar KI, Kannan TP. Identification and characterization of intraoral and dermal fibroblasts revisited. Curr Stem Cell Res Ther. 2017;12:675–81.
Groeger SE, Meyle J. Epithelial barrier and oral bacterial an infection. Periodontol 2000. 2015;69:46–67.
Herrera D, Sanz M, Shapira L, Brotons C, Chapple I, Frese T, et al. Periodontal illnesses and cardiovascular illnesses, diabetes, and respiratory illnesses: abstract of the consensus report by the European federation of periodontology and WONCA Europe. Eur J Gen Pract. 2024;30:2320120.
Yamazaki Okay, Kamada N. Exploring the oral-gut linkage: interrelationship between oral and systemic illnesses. Mucosal Immunol. 2024;17:147–53.
Horliana ACRT, Chambrone L, Foz AM, Artese HPC, Rabelo M, de Pannuti S. Dissemination of periodontal pathogens within the bloodstream after periodontal procedures: A scientific evaluate. PLoS ONE. 2014;9:e98271.
Carrizales-Sepúlveda EF, Ordaz-Farías A, Vera-Pineda R, Flores-Ramírez R. Periodontal illness, systemic irritation and the danger of heart problems. Coronary heart Lung Circ. 2018;27:1327–34.
Wu P, Wu W, Zhang S, Han J, Liu C, Yu H, et al. Therapeutic potential and pharmacological significance of extracellular vesicles derived from conventional medicinal crops. Entrance Pharmacol. 2023;14:1272241.https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1272241/full
Mu N, Li J, Zeng L, You J, Li R, Qin A, et al. Plant-Derived Exosome-Like nanovesicles: present progress and prospects. Int J Nanomed. 2023;18:4987–5009.
Sundaram Okay, Teng Y, Mu J, Xu Q, Xu F, Sriwastva MK, et al. Outer membrane vesicles launched from Garlic Exosome-like nanoparticles (GaELNs) prepare intestine micro organism that reverses sort 2 diabetes by way of the intestine‐Mind axis. Small. 2024;20:e2308680.
Zou J, Track Q, Shaw PC, Wu Y, Zuo Z, Yu R. Tangerine Peel-Derived Exosome-Like nanovesicles alleviate hepatic steatosis induced by sort 2 diabetes: evidenced by regulating lipid metabolism and intestinal microflora. Int J Nanomed. 2024;19:10023–43.
Miya MB, Ashutosh, Maulishree, Chandra Gupta P, Pathak V, Mishra R, et al. Therapeutic results of OXY- exo in diabetic wound damage. Biochem Biophys Res Commun. 2024;731:150398.
He C, Wang Okay, Xia J, Qian D, Guo J, Zhong L, et al. Pure exosomes-like nanoparticles in mung bean sprouts possesses anti-diabetic results by way of activation of PI3K/Akt/GLUT4/GSK-3β signaling pathway. J Nanobiotechnol. 2023;21:349.
Tan M, Liu Y, Xu Y, Yan G, Zhou N, Chen H, et al. Plant-Derived exosomes as novel nanotherapeutics contrive Glycolysis Reprogramming-Mediated angiogenesis for diabetic ulcer therapeutic. Biomater Res. 2024;28:0035.
Bajaj G, Choudhary D, Singh V, Priyadarshi N, Garg P, Mantri SS, et al. MicroRNAs Dependent G‐ELNs Based mostly Intervention Improves Glucose and Fatty Acid Metabolism Whereas Defending Pancreatic β‐Cells in Sort 2 Diabetic Mice. Small. 2025;21:e2409501.
Garcia-Ibañez P, Roses C, Agudelo A, Milagro FI, Barceló AM, Viadel B, et al. The affect of crimson cabbage extract nanoencapsulated with brassica plasma membrane vesicles on the intestine Microbiome of overweight volunteers. Meals. 2021;10:1038.
Lee JH, Kang SJ, Rhee WJ. Exploiting Spinach-Derived extracellular vesicles for Anti-Weight problems remedy by means of lipid accumulation Inhibition. Adv Ther. 2024;n/a:2400150.
Pang W, Zuo Z, Solar W, Zhang Z, Wang J, Wang Y, et al. Kidney bean derived exosome-like nanovesicles ameliorate high-fat diet-induced weight problems by way of reshaping intestine microbiota. J Funct Meals. 2024;113:105997.
Bian Y, Li W, Jiang X, Yin F, Yin L, Zhang Y, et al. Garlic-derived exosomes carrying miR-396e shapes macrophage metabolic reprograming to mitigate the inflammatory response in overweight adipose tissue. J Nutr Biochem. 2023;113:109249.
Dolma L, Damodaran A, Panonnummal R, Nair SC. Exosomes remoted from citrus lemon: a promising candidate for the therapy of alzheimer’s illness. Ther Supply. 2024;15:507–19.
Timms Okay, Holder B, Day A, Mclaughlin J, Forbes KA, Westwood M. Watermelon-Derived extracellular vesicles affect human ex vivo placental cell conduct by altering intestinal secretions. Mol Nutr Meals Res. 2022;66:e2200013.
Shinjo T, Nishimura F. The bidirectional affiliation between diabetes and periodontitis, from primary to scientific. Jpn Dent Sci Rev. 2024;60:15–21.
Mirnic J, Djuric M, Brkic S, Gusic I, Stojilkovic M, Tadic A, et al. Pathogenic mechanisms that Might hyperlink periodontal illness and kind 2 diabetes Mellitus—The function of oxidative stress. Int J Mol Sci. 2024;25:9806.
Magkos F, Hjorth MF, Astrup A. Weight loss plan and train within the prevention and therapy of sort 2 diabetes mellitus. Nat Rev Endocrinol. 2020;16:545–55.
Gordon H, Salim N, Tong S, Walker S, De Silva M, Cluver C, et al. Metformin use and preeclampsia danger in girls with diabetes: a two-country cohort evaluation. BMC Med. 2024;22:418.
Nabrdalik Okay, Hendel M, Irlik Okay, Kwiendacz H, Łoniewski I, Bucci T, et al. Gastrointestinal adversarial occasions of metformin therapy in sufferers with sort 2 diabetes mellitus: a scientific evaluate and meta-analysis with meta-regression of observational research. BMC Endocr Disord. 2024;24:206.https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-024-01727-w
Jin E, Yang Y, Cong S, Chen D, Chen R, Zhang J, et al. Lemon-derived nanoparticle-functionalized hydrogels regulate macrophage reprogramming to advertise diabetic wound therapeutic. J Nanobiotechnol. 2025;23:68.
Guo X, Li X, Liao C, Feng X, He T. Periodontal illness and subsequent danger of cardiovascular consequence and all-cause mortality: A meta-analysis of potential research. PLoS ONE. 2023;18:e0290545.
Wang W, Yang Z, Wang Y, Gao H, Wang Y, Zhang Q. Affiliation between periodontitis and carotid artery calcification: A scientific evaluate and Meta-Evaluation. Biomed Res Int. 2021;2021:1–9.
Shang J, Liu H, Zheng Y, Zhang Z. Position of oxidative stress within the relationship between periodontitis and systemic illnesses. Entrance Physiol. 2023;14:1210449.https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1210449/full
Joshi C, Bapat R, Anderson W, Dawson D, Hijazi Okay, Cherukara G. Detection of periodontal microorganisms in coronary atheromatous plaque specimens of myocardial infarction sufferers: a scientific evaluate and meta-analysis. Developments Cardiovasc Med. 2021;31:69–82.
Libby P. Irritation in atherosclerosis. Arterioscler, thromb. Vasc Biol. 2012;32:2045–51.
Moore KJ, Tabas I. Macrophages within the pathogenesis of atherosclerosis. Cell. 2011;145:341–55.
Chen S, Li Q, Shi H, Li F, Duan Y, Guo Q. New insights into the function of mitochondrial dynamics in oxidative stress-induced illnesses. Biomed Pharmacother. 2024;178:117084.
Wu Y, Xing L, Lu L, Liu S, Zhao D, Lin L, et al. Alterations within the salivary Microbiome and metabolism in sufferers with carotid atherosclerosis from rural Northeast China. J Am Coronary heart Assoc. 2024;13:e034014.
Reytor-González C, Parise-Vasco JM, González N, Simancas-Racines A, Zambrano-Villacres R, Zambrano AK, et al. Weight problems and periodontitis: a complete evaluate of their interconnected pathophysiology and scientific implications. Entrance Nutr. 2024;11:1440216.
Zhao P, Xu A, Leung WK. Weight problems, bone loss, and periodontitis: the interlink. Biomolecules. 2022;12:865.
Suvan JE, Petrie A, Nibali L, Darbar U, Rakmanee T, Donos N, et al. Affiliation between chubby/weight problems and elevated danger of periodontitis. J Clin Periodontol. 2015;42:733–9.
Müller TD, Blüher M, Tschöp MH, DiMarchi RD. Anti-obesity drug discovery: advances and challenges. Nat Rev Drug Discovery. 2022;21:201–23.
Chae Y-R, Lee H-B, Lee YR, Yoo G, Lee E, Park M, et al. Ameliorating results of orostachys Japonica in opposition to high-fat diet-induced weight problems and intestine dysbiosis. J Ethnopharmacol. 2024;333:118443.
Dong S, Wu S, Li L, Hao F, Wu J, Liao Z, et al. Alleviation of lipid metabolic dysfunction by means of regulation of intestinal bacteriophages and micro organism by inexperienced tea polyphenols in ob/ob mice. Meals Chem. 2024;456:139988.
Wang J, Zhuang P, Lin B, Li H, Zheng J, Tang W, et al. Intestine microbiota profiling in overweight kids from southeastern China. BMC Pediatr. 2024;24:193.
Kirk NM, Liang Y, Ly H. Pathogenesis and virulence of coronavirus illness: comparative pathology of animal fashions for COVID-19. Virulence. 2024;15:2316438.
Molina A, Huck O, Herrera D, Montero E. The affiliation between respiratory illnesses and periodontitis: a scientific evaluate and meta-analysis. J Clin Periodontol. 2023;50:842–87.
Kalarikkal SP, Sundaram GM. Edible plant-derived Exosomal micrornas: exploiting a cross-kingdom regulatory mechanism for focusing on SARS-CoV-2. Toxicol Appl Pharmacol. 2021;414:115425.
Wang Z, Cui Okay, Costabel U, Zhang X. Nanotechnology‐facilitated vaccine improvement throughout the coronavirus illness 2019 (COVID‐19) pandemic. Exploration. 2022;2:20210082.https://onlinelibrary.wiley.com/doi/10.1002/EXP.20210082
Gai C, Pomatto MAC, Deregibus MC, Dieci M, Piga A, Camussi G. Edible plant-derived extracellular vesicles for oral mRNA vaccine supply. Nato Adv Sci Inst Se. 2024;12:200.
Pomatto MAC, Gai C, Negro F, Massari L, Deregibus MC, Grange C, et al. Plant-Derived extracellular vesicles as a supply platform for RNA-Based mostly vaccine: feasibility research of an oral and intranasal SARS-CoV-2 vaccine. Pharmaceutics. 2023;15:974.
Pomatto MAC, Gai C, Negro F, Massari L, Deregibus MC, De Rosa FG, et al. Oral supply of mRNA vaccine by Plant-Derived extracellular vesicle carriers. Cells. 2023;12:1826.
Raimondo S, Giavaresi G, Lorico A, Alessandro R. Extracellular vesicles as organic shuttles for focused therapies. Int J Mol Sci. 2019;20:1848.
Barbarisi A, Visconti V, Lauritano D, Cremonini F, Caccianiga G, Ceraulo S. Correlation between periodontitis and onset of Alzheimer’s illness: a literature evaluate. Dentistry J. 2024;12:331.
Soiniemi L, Solje E, Suominen AL, Kanninen KM, Kullaa AM. The affiliation between oral illnesses and neurodegenerative problems. Journal of Alzheimer’s Illness. 2024;102:577–86.
Pawar S, Rauf MA, Abdelhady H, Iyer AK. Tau‐focusing on nanoparticles for therapy of Alzheimer’s illness. Exploration. 2025;5:20230137.
Malaguarnera M, Cabrera-Pastor A. Rising function of extracellular vesicles as biomarkers in neurodegenerative illnesses and their scientific and therapeutic potential in central nervous system pathologies. Int J Mol Sci. 2024;25:10068.
Wu J, Wu J, Tang B, Zhang Z, Wei F, Yu D, et al. Results of various periodontal interventions on the danger of adversarial being pregnant outcomes in pregnant girls: a scientific evaluate and community meta-analysis of randomized managed trials. Entrance Public Well being. 2024;12:1373691.
Vivares-Builes AM, Rangel-Rincón LJ, Botero JE, Agudelo-Suárez AA. Gaps in information in regards to the affiliation between maternal periodontitis and adversarial obstetric outcomes: an umbrella evaluate. J Evid Based mostly Dent Pract. 2018;18:1–27.
Bruić M, Pirković A, Borozan S, Nacka Aleksić M, Jovanović Krivokuća M, Spremo-Potparević B. Antioxidative and anti inflammatory results of taxifolin in H2O2-induced oxidative stress in HTR-8/SVneo trophoblast cell line. Reprod Toxicol. 2024;126:108585.
Li M, Wu X, An P, Dang H, Liu Y, Liu R. Results of Resveratrol on autophagy and the expression of inflammasomes in a placental trophoblast oxidative stress mannequin. Life Sci. 2020;256:117890.
Holder B, Jones T, Sancho Shimizu V, Rice TF, Donaldson B, Bouqueau M, et al. Macrophage exosomes induce placental inflammatory cytokines: A novel mode of Maternal–Placental messaging. Site visitors. 2016;17:168–78.
Kitamoto S, Kamada N. Periodontal reference to intestinal irritation: Microbiological and immunological mechanisms. Periodontol 2000. 2022;89:142–53.
Yamazaki Okay. Oral-gut axis as a novel organic mechanism linking periodontal illness and systemic illnesses: A evaluate. Japanese Dent Sci Rev. 2023;59:273–80.
Jia X, Yang R, Li J, Zhao L, Zhou X, Xu X. Intestine-bone axis: a non-negligible contributor to periodontitis. Entrance Cell Infect Microbiol. 2021;11:752708.
Han N, Li X, Du J, Xu J, Guo L, Liu Y. The impacts of oral and intestine microbiota on alveolar bone loss in periodontitis. J Periodontal Res. 2023;58:1139–47.
Wang X, Liu Y, Dong X, Duan T, Wang C, Wang L, et al. peu-MIR2916-p3-enriched Garlic exosomes ameliorate murine colitis by reshaping intestine microbiota, particularly by boosting the anti-colitic bacteroides Thetaiotaomicron. Pharmacol Res. 2024;200:107071.
Mondal J, Pillarisetti S, Junnuthula V, Saha M, Hwang SR, Park I, et al. Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic purposes. J Managed Launch. 2023;353:1127–49.
Kumar MN, Kalarikkal SP, Jayaram Y, Narayanan J, Sundaram GM. Protocol to provide plant-based hybrid nanovesicles from contemporary turmeric and pepper utilizing polyethylene glycol. STAR Protoc. 2024;5:102924.
Lu X, Xu Z, Shu F, Wang Y, Han Y, Yang X, et al. Reactive oxygen species responsive multifunctional fusion extracellular nanovesicles: potential remedies for acute coronary heart transplant rejection. Adv Mater. 2024;36:2406758.
Track J, Jung H, You G, Mok H. Most cancers-Cell‐Derived hybrid vesicles from MCF‐7 and HeLa cells for Twin‐Homotypic focusing on of anticancer medication. Macromol Biosci. 2021;21:2100067.
Leng Y, Yang L, Zhu H, Li D, Pan S, Yuan F. Stability of blueberry extracellular vesicles and their gene regulation results in intestinal Caco-2 cells. Biomolecules. 2023;13:1412.
Nemidkanam V, Chaichanawongsaroj N. Characterizing Kaempferia parviflora extracellular vesicles, a nanomedicine candidate. PLoS ONE. 2022;17:e0262884.
Zhao Z, Lacombe J, Simon L, Sanchez-Ballester NM, Khanishayan A, Shaik N, et al. Bodily, biochemical, and organic characterization of olive-derived lipid nanovesicles for drug supply purposes. J Nanobiotechnol. 2024;22:720.
Jang J, Jeong H, Jang E, Kim E, Yoon Y, Jang S, et al. Isolation of high-purity and high-stability exosomes from ginseng. Entrance Plant Sci. 2022;13:1064412. https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2022.1064412/full
Kim Okay, Park J, Sohn Y, Oh C-E, Park J-H, Yuk J-M, et al. Stability of plant Leaf-Derived extracellular vesicles based on preservative and storage temperature. Pharmaceutics. 2022;14:457.
Kawai-Harada Y, El Itawi H, Komuro H, Harada M. Analysis of EV storage buffer for environment friendly preservation of engineered extracellular vesicles. Int J Mol Sci. 2023;24:12841.