[HTML payload içeriği buraya]
28 C
Jakarta
Sunday, May 17, 2026

An orally administered gene enhancing nanoparticle boosts chemo-immunotherapy in colorectal most cancers


  • Ward, R. A. et al. Challenges and alternatives in most cancers drug resistance. Chem. Rev. 121, 3297–3351 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L. & Kroemer, G. Immunogenic cell demise in most cancers and infectious illness. Nat. Rev. Immunol. 17, 97–111 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Thibaudin, M. et al. First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal most cancers: a section 1b/2 trial. Nat. Med. 29, 2087–2098 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhou, C. et al. Outcomes and toxicities of immune checkpoint inhibitors in colorectal most cancers: a real-world retrospective evaluation. Most cancers Commun. 41, 921–924 (2021).

    Article 

    Google Scholar
     

  • Schmitt, M. et al. Colon tumour cell demise causes mTOR dependence by paracrine P2X4 stimulation. Nature 612, 347–353 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mariya, T. et al. Prognostic affect of human leukocyte antigen class I expression and affiliation of platinum resistance with immunologic profiles in epithelial ovarian most cancers. Most cancers Immunol. Res. 2, 1220–1229 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Giddings, E. L. et al. Mitochondrial ATP fuels ABC transporter-mediated drug efflux in most cancers chemoresistance. Nat. Commun. 12, 2804 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu, Z. et al. Mitochondrial DNA stress signalling protects the nuclear genome. Nat. Metab. 1, 1209–1218 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lao, L. et al. CD8+ T cell-dependent transforming of the tumor microenvironment overcomes chemoresistance. Most cancers Immunol. Res. 11, 320–338 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kang, B. H. et al. Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone community. Cell 131, 257–270 (2007).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang, X. et al. Cyclophilin D deficiency attenuates mitochondrial perturbation and ameliorates hepatic steatosis. Hepatology 68, 62–77 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Zhao, Q. et al. Concentrating on mitochondria-located circRNA SCAR alleviates NASH through decreasing mROS output. Cell 183, 76–93.e22 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Denorme, F. et al. Platelet necrosis mediates ischemic stroke end result in mice. Blood 135, 429–440 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Feng, Y., Madungwe, N. B., Tombo, N., Li, L. & Bopassa, J. C. Summary 420: RIP3 interacts with mitofilin within the inside membrane of mitochondria to induce cardiomyocytes necrosis after ischemia/reperfusion. Circ. Res. 123, A420 (2018).

    Article 

    Google Scholar
     

  • Costantino, E. et al. TRAP1, a novel mitochondrial chaperone liable for multi-drug resistance and safety from apoptotis in human colorectal carcinoma cells. Most cancers Lett. 279, 39–46 (2009).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yoon, N. G. et al. Mitoquinone inactivates mitochondrial chaperone TRAP1 by blocking the shopper binding web site. J. Am. Chem. Soc. 143, 19684–19696 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gewirth, D. T. Paralog particular Hsp90 inhibitors—a quick historical past and a brilliant future. Curr. Prime. Med. Chem. 16, 2779–2791 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tong, S., Moyo, B., Lee, C. M., Leong, Okay. & Bao, G. Engineered supplies for in vivo supply of genome-editing equipment. Nat. Rev. Mater. 4, 726–737 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Abramson, A. et al. Oral mRNA supply utilizing capsule-mediated gastrointestinal tissue injections. Matter 5, 975–987 (2022).

    Article 
    CAS 

    Google Scholar
     

  • Yoo, J., Nhean, S., Vogel, P., Rybkin, I. I. & Kostoff, D. Implementation of oral chemotherapy administration program within the massive built-in well being care system and its affect on affected person security. J. Clin. Oncol. 36, 279 (2018).

    Article 

    Google Scholar
     

  • Brown, T. D., Whitehead, Okay. A. & Mitragotri, S. Supplies for oral supply of proteins and peptides. Nat. Rev. Mater. 5, 127–148 (2020).

    Article 

    Google Scholar
     

  • Li, B. et al. Trimethylamine N-oxide-derived zwitterionic polymers: a brand new class of ultralow fouling bioinspired supplies. Sci. Adv. 5, eaaw9562 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shao, Q. & Jiang, S. Molecular understanding and design of zwitterionic supplies. Adv. Mater. 27, 15–26 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bansil, R. & Turner, B. S. The biology of mucus: composition, synthesis and group. Adv. Drug Deliv. Rev. 124, 3–15 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Duncan, G. A., Jung, J., Hanes, J. & Suk, J. S. The mucus barrier to inhaled gene remedy. Mol. Ther. 24, 2043–2053 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mirji, G. et al. The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic most cancers. Sci. Immunol. 7, eabn0704 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Teft, W. A. et al. Identification and characterization of trimethylamine-N-oxide uptake and efflux transporters. Mol. Pharm. 14, 310–318 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kato, Y. et al. Artificial zwitterions as environment friendly non-permeable cryoprotectants. Comm. Chem. 4, 151 (2021).

    Article 
    CAS 

    Google Scholar
     

  • Ganguly, P., Boserman, P., van der Vegt, N. F. A. & Shea, J.-E. Trimethylamine N-oxide counteracts urea denaturation by inhibiting protein–urea preferential interplay. J. Am. Chem. Soc. 140, 483–492 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xie, W. J. et al. Giant hydrogen-bond mismatch between TMAO and urea promotes their hydrophobic affiliation. Chem 4, 2615–2627 (2018).

    Article 
    CAS 

    Google Scholar
     

  • Landriscina, M. et al. TRAP1, a novel antiapoptotic gene liable for multidrug resistance in human colorectal carcinoma cells. J. Clin. Oncol. 27, 2541 (2009).

    Article 

    Google Scholar
     

  • Chae, Y. C. et al. Management of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s. Most cancers Cell 22, 331–344 (2012).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ariës, I. M. et al. PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia. J. Exp. Med. 215, 3094–3114 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lu, L. et al. Nanoparticle-based oral supply techniques for colon focusing on: rules and design methods. Sci. Bull. 61, 670–681 (2016).

    Article 
    CAS 

    Google Scholar
     

  • Hone Lopez, S. et al. The intestine wall’s potential as a accomplice for precision oncology in immune checkpoint remedy. Most cancers Deal with. Rev. 107, 102406 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lee, Y., Kamada, N. & Moon, J. J. Oral nanomedicine for modulating immunity, intestinal barrier capabilities, and intestine microbiome. Adv. Drug Deliv. Rev. 179, 114021 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhao, Z. et al. Organoids. Nat. Rev. Strategies Prim. 2, 94 (2022).

    Article 
    CAS 

    Google Scholar
     

  • Drost, J. & Clevers, H. Organoids in most cancers analysis. Nat. Rev. Most cancers 18, 407–418 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li, X., Bechara, R., Zhao, J., McGeachy, M. J. & Gaffen, S. L. IL-17 receptor–based mostly signaling and implications for illness. Nat. Immunol. 20, 1594–1602 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Total, C. M. & Kleifeld, O. Validating matrix metalloproteinases as drug targets and anti-targets for most cancers remedy. Nat. Rev. Most cancers 6, 227–239 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhao, H. et al. Wnt signaling in colorectal most cancers: pathogenic position and therapeutic goal. Mol. Most cancers 21, 144 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pan, Okay. & Xie, Y. LncRNA FOXC2-AS1 enhances FOXC2 mRNA stability to advertise colorectal most cancers development through activation of Ca2+-FAK sign pathway. Cell Loss of life Dis. 11, 434 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Baghdadi, M. et al. Chemotherapy-induced IL34 enhances immunosuppression by tumor-associated macrophages and mediates survival of chemoresistant lung most cancers cells. Most cancers Res. 76, 6030–6042 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Related Articles

    LEAVE A REPLY

    Please enter your comment!
    Please enter your name here

    Latest Articles